Renal Oncocytoma of the Native Kidney after Renal Transplantation

Abstract

Patients with acquired cystic kidney disease (ACKD) are at an increased risk of renal neoplasms. Frequent tumors are adenomas and renal cell carcinomas. However, renal oncocytomas may occur in patients with ACKD. Little is known about oncocytomas of the native kidney following renal transplantation. By means of B scan ultrasonography, a solid and echo-inhomogeneous renal mass was incidentically observed in the right native kidney of a 28-year-old female patient with ACKD 4 years following renal transplantation. A nephrectomy was performed. The histological examination revealed a renal oncocytoma. The increased prevalence of neoplasms in the case of ACKD and following renal transplantation requires careful monitoring of the patients concerned. In very rare cases a renal oncocytoma may develop in the native kidney after renal transplantation.

Renal oncocytoma in a kidney transplant patient: the imaging features on contrast-enhanced ultrasonography (CEUS): a case report

“…To the best of our knowledge, this is the first case of a renal oncocytoma in an asymptomatic renal transplant patient with microscopic hematuria in which a hypervascular mass with heterogeneous enhancement and pseudocapsule was shown by using CEUS, suggesting malignancy. Furthermore, only four cases of renal transplant recipients with oncocytomas in native kidneys have been reported in the literature 15…”

Multiple bilateral oncocytomas of the native kidneys following renal transplantation: report of a rare case and review of the literature

“…Microscopically, ROs are characterized by round or polygonal cells that are eosinophilic epithelial cells called oncocytes with a mitochondria-rich cytoplasm arranged in trabecular or tubular patterns [2,4,10]. Histological differential diagnosis from a chromophobe RCC is very important and can be challenging.…”

“…Riehl et al . [10] discuss a young renal-graft recipient who developed a solitary RO in a native kidney with ACKD, 4 years after RT. In this case report, we present a unique case of renal oncocytomatosis of the native kidneys in a renal transplant recipient with normal graft function, 6 years following RT.…”

“…Development of a RO in the native kidneys following renal transplantation (RT) is very uncommon with only four cases published in the world literature [7-10]. We report herein the first case of a bilateral multifocal RO of the native kidneys in a female transplant recipient 6 years after RT.…”