Renal Oncocytoma: Review of Literature and Report of Six Cases

Renal oncocytosis in a pediatric patient: Case report and review of the literature

“…However, 4-6% will have multifocal disease while 4% will have bilateral disease (4). Patients range in age from 10 to 94 years of age (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12), with most occurring in the seventh decade of life. Our 12 year old patient is one of the younger ones described to date.…”

“…Specific genetic conditions, such as Birt-Hogg-Dube (BHD) and Von -Hippel-Lindau syndrome, can also be associated with renal oncocytosis (1). However, very few paediatric cases of renal oncocytoma have been described (4)(5)(6)(7)(8).…”

Renal Oncocytoma: A True Clinical Entity?

“…There is ultrastructural evidence that the oncocytic cells of the kidney come from the proximal convoluted tubules [12] (although some authors [13] wonder whether it originates in the thick portion of Henle's loop). Unquestionably oncocytic areas have been recognized in granular cell carcinomas [14,15], The existence of renal tumors with overlapping oncocytoma characteristics and granular cell carcinomas [2] (there fore aspirative cytology or intraoperatory biopsy cannot be considered as absolutely reliable methods [2,3]) has been reported, as have renal oncocytoma with métas tasés [7], If all these findings are considered together, it is easy to observe that there are no big differences between the oncocytoma and well-differentiated clear-cell carcino mas. To support the finding that renal oncocytoma is a true clinico-pathological entity, some authors [16,17] have studied it on the basis of the benignity of the evo lution [1,5,7] and the angiographic peculiarities.…”