Renal outcomes in mixed proliferative and membranous lupus nephritis (Class III/IV + V): A long-term observational study

Abstract

This study demonstrated a combination of proliferative and membranous LN (ISN/RPS Class III/IV + V) predicts poor renal outcomes.

Long‐term renal outcomes in multi‐ethnic Southeast Asians with lupus nephritis: a retrospective cohort study

“…Other studies also identified gender, proteinuria and histological class to affect renal progression. Among the eight patients seronegative for both ANA and anti‐dsDNA, four had membranous lupus nephropathy.…”

“…32 It is thus important to minimise occurrence and duration of flares with adequate immunosuppressive therapy, balanced against the risk of immunosuppressant-related complications such as infections. 33 Other studies also identified gender, 13,26,34 proteinuria 13,26,29 and histological class 25 to affect renal progression. Among the eight patients seronegative for both ANA and anti-dsDNA, four had membranous lupus nephropathy.…”

“…A Norwegian study of 178 patients followed up over 8.5 years found that 20% developed ESRD, while cumulative ESRD incidence among patients in the Systemic Lupus International Collaborating Clinics cohort was 10.1% . Ten‐year renal survival among Chinese and Japanese ranged from 87% to 94% . CKD, defined as GFR <60 mL/min/1.73 m 2 for ≥3 months, occurred in 22% of 322 Koreans within 10 years after diagnosing LN .…”

“…24 Ten-year renal survival among Chinese and Japanese ranged from 87% to 94%. 13,25,26 CKD, defined as GFR <60 mL/min/1.73 m 2 for ≥3 months, occurred in 22% of 322 Koreans within 10 years after diagnosing LN. 12 In contrast, 5-year renal survival ranged between 48% and 84% in Africans.…”

Cleaved Form of Osteopontin in Urine as a Clinical Marker of Lupus Nephritis

“…Lupus nephritis (LN) is one of multiple organ manifestations of SLE, and is an important prognostic factor [1]; therefore, new, improved therapeutic approaches and biomarkers are needed. Urine protein and serum creatinine (Cre) are traditionally used as markers of LN.…”