Renal Papillary Necrosis: Roentgenologic Diagnosis and Formation of Calculi

Phenacetin Abuse and Chronic Pyelonephritis

“…As the frequency of analgesic abuse in subjects with renal stones does not differ from that of the controls and is far below that of chronic pyelonephritics, the question arises whether analgesic abuse predisposes to the formation of renal stones, perhaps on sloughed-off particles of necrotic medullary tissue. An increased frequency of renal stones among patients with analgesic abuse and a similar conclusion about their pathogenesis was made by Lagergren and Lindvall [25] and Reichelt et al [32]. There was no difference in the degree of proteinuria, excretion of casts or in the rela tively early weakening of the concentrating power compared to the reduction of the GFR between those 'pyelonephritics' with and with out analgesic abuse.…”

Analgesie nephropathy‐A review of the literature, 1967–1970

“…Rutishauser and Morard," for example, and Simon and associates" published details of autopsy eases in whieh renal papillary neerosis was found in the absence of diabetes mellitus or urinary tract obstruction. There were other similar reports'- 34, 49 In the majority of eases the lesion was thought to be associated with acute or ehronic pyelonephritis, though Robbins and Angrist 69 suggested that, "The infarct-like neerosis which is the chief characteristie of renal papillitis at once suggests vaseular oeclusion. "…”