Renal Parencymal Malacoplakia Successfully Treated With Conservative Therapy; A Case Report

Tanaka, Isao; Taguchi, Tomoaki; Tsunemori, Hiroyuki; Imanishi, Osamu; Yamanaka, Nozomu; Kondo, Takeshi; Ito, Rieko

doi:10.5980/jpnjurol1989.98.839

Cited by 3 publications

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“…For patients with multifocal disease, antibiotic treatment may be favored, whereas as for patients with unifocal disease, surgical treatment is more likely to be indicated. Among antibiotics, quinolones as well as cotrimoxazole, rifampin, doxycycline, trimethoprim, and vancomycin have been shown to be effective [9,10]. In the present case of multifocal renal malacoplakia, short term treatment with ceftriaxone and ofloxacin followed by long term treatment with sulfamethoxazole/trimethoprim resulted in successful resolution.…”

Section: Discussionmentioning

confidence: 73%

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Renal malacoplakia: Case report of a differential diagnosis for renal cell carcinoma

et al. 2012

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SummaryBackground:Renal malacoplakia is a very rare chronic inflammatory disorder characterized by specific infiltration of tissue by inflammatory cells, and presents similar radiological characteristics to those of renal cell carcinoma.Case Report:A 54-year old woman, with a 37-year history of smoking, weight loss, anorexia, asthenia, and night sweats, was included in an antiangiogenesis clinical trial. Clinical signs of inflammation were apparent in the right lumbar region without functional limitations. Previous imagery identified a mass infiltrating the lower pole of the right kidney, extending to the psoas, perinephretic region and ganglia. Biological testing revealed inflammation and a urinary tract infection, treated with ciprofloxacin. Based on histology of a renal puncture biopsy, clear cell carcinoma with oxyphilic cells was suspected but not confirmed by immunohistochemistry.Urine analysis was positive for Escherichia Coli. Computed tomodensitometry revealed three masses (right kidney, between right psoas and the inferior vena cava, and right psoas) and a second puncture biopsy confirmed malacoplakia. After successful antibiotherapy, a right-sided nephrectomy was performed. The patient now shows no evidence of disease.Conclusions:This case underscores the importance of excluding the differential diagnosis of renal malacoplakia before undertaking partial or total nephrectomy and/or initiating neoadjuvant treatment for renal cell carcinoma.

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Section: Discussionmentioning

confidence: 73%

“…Urine analysis was positive for E. coli . Fever resolved after treatment with ceftriaxone and ofloxacin [9]. An additional year of treatment with sulfamethoxazole 800 mg/trimethoprim 160 mg bid was prescribed according to international recommendations [3,4], with succesful clinical outcome.…”

Section: Case Reportmentioning

confidence: 99%

Renal malacoplakia: Case report of a differential diagnosis for renal cell carcinoma

et al. 2012

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Kidney and Ureter Inflammation

Gupta

Narahari

2019

Blandy's Urology

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A Case of Renal Parenchymal Malakoplakia Presenting as Sepsis and Treated With Nephrectomy

Kitajima¹,

Koike²,

Koizumi³

et al. 2011

Jpn. j. urol

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Malakoplakia is a rare chronic inflammatory condition characterized by defective macrophage function, most of which involve the genitourinary tract, and renal parenchymal involvement is uncommon. We present a case of malakoplakia affecting renal parenchyma. A 46-year-old woman with pyrexia and jaundice was referred to our department. Abdominal enhanced CT scan revealed a left pyelonephritis with ureteral stone and bilateral renal abscesses. Despite the insertion of a left ureteral stent and administration of antibiotics, the patient showed persistent high fever and elevated CRP, and no obvious improvement in clinical and imaging data. In view of the limited effectiveness of the conservative treatment in this case, we decided to perform left nephrectomy. The diagnosis of malakoplakia was made based on the histopathological findings of von Hansemann cells and Michaelis-Guttmann bodies detected in the nephrectomy specimen. She is clinically healthy up to the present (50 months after surgery) with normal clinical indicators and CT findings.

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Renal Parencymal Malacoplakia Successfully Treated With Conservative Therapy; A Case Report

Cited by 3 publications

References 0 publications

Renal malacoplakia: Case report of a differential diagnosis for renal cell carcinoma

Renal malacoplakia: Case report of a differential diagnosis for renal cell carcinoma

Kidney and Ureter Inflammation

A Case of Renal Parenchymal Malakoplakia Presenting as Sepsis and Treated With Nephrectomy

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