Renal Perfusion and Nephronal Structure

Glomerular Endothelial Dysfunction and Altered Cytokines in Severe Nephrosis

“…Such procoagulant activity is substantiated by the presence of shortened platelet half life, blood hypercoagulability and hyperviscosity due to overcompensatory production, fibrin or traced element of fibrin, elevated fibrin degradation product in the serum and urine [1]. However, the ability of the glomerular endothelium to release an adequate amount of vasodilators, delineated by the mean of the intrarenal hemodynamic study (renal plasma flow 704 B 102 ml/min; control 600 ml/ min/1.73 m 2 ), is well maintained in this mild category of nephrosis [2]. The degree of glomerular endothelial dysfunction is amplified in other forms of nephrosis with greater clinical severity.…”

Peritubular Capillary Flow and Tubular Function in Idiopathic Nephrotic Syndrome

“…The correlation between renal perfusion and nephronal structure has recently been proposed [1]. In essence, a normal or balanced renal perfusion, as observed in minimal change disease, is usually associated with an intact nephronal structure, absence of glomerulosclerosis or tubulointerstitial fibrosis, and a benign clinical course.…”

Endothelial Cell Cytotoxicity and Renal Hypoperfusion in Idiopathic Nephrotic Syndrome

“…In this regard, it has recently been demonstrated by intrarenal hemodynamics that a normal renal perfusion is usually associated with an intact nephronal structure and function, whereas renal hypoperfusion is a unique characteristic observation documented in severe forms of idiopathic nephrosis associated with nephronal death such as glomerulosclerosis and tubulointerstitial fibrosis [2]. In addition, it is of notion that there is a progressive reduction in renal perfusion, as the disease severity progresses [3]. This view is delineated by multiple regression analysis which demonstrates that the reduction in renal perfusion is inversely proportional to the intensity of tubulointerstitial disease [4].…”