Renal Primitive Neuroectodermal Tumor in a Child with Brain Metastasis: A Case Report

Naimi, Azar; Soltan, Maryam; Saberi, Elahe; Riahinezhad, Maryam

doi:10.4172/2476-2024.1000143

Cited by 2 publications

(4 citation statements)

References 6 publications

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“…PNET was initially identified as member of small round tumors by Arthur Purdy Stout in 1918. It typically occurs in bone or soft tissue and rarely reported a renal localization [3]. The origin of the tumor is debatable but studies show that it is derived from cells that have migrated from the neural tube with variable capability of ectodermal or neuronal differentiation and these tumors can arise anywhere from brain to the sacrum.…”

Section: Discussionmentioning

confidence: 99%

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Primitive neuroectodermal tumor of the kidney: a rare case

et al. 2021

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Background Primitive neuroectodermal tumor commonly occurs in bones and is equivalent to Ewing’s sarcoma. Very few cases have been reported in the literature and they had a very different presentation and very aggressive behavior. Case presentation We present a case of a young 23-year-old male who presented with complaints of pain in left lumbar region of abdomen since 8 months and hematuria off and on. CT scan of the abdomen was done which revealed a large heterogeneously enhancing mass lesion in the left lumbar region arising from the superior and mid-pole of left kidney showing multiple non-enhancing necrotic areas. A diagnosis of left renal cell carcinoma was kept. Through the transperitoneal approach, the left kidney was approached and a left radical nephrectomy was done. The histopathology report revealed the tumor cells to be positive for CD99 and focally positive for Vimentin and negative for cytokeratin thereby making a diagnosis of primary neuroectodermal tumor (PNET). Conclusions Renal PNET is a rare renal malignancy that should be kept in the differential diagnosis of a renal SOL especially when it is a presenting feature in adolescent and young adult. It has a very aggressive course and multimodal therapy has to be considered in its treatment

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Section: Discussionmentioning

confidence: 99%

“…They are seen in relatively young population. The diagnosis of renal PNET is mainly based on histopathology and immunohistochemistry, supported by cytogenetic analysis; thus, preoperative diagnosis is challenging [3].…”

Section: Introductionmentioning

confidence: 99%

Primitive neuroectodermal tumor of the kidney: a rare case

et al. 2021

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“…Renal PNET is more aggressive than PNET arising from other locations 4. Almost half of the patients present with distant metastasis, most commonly to regional lymph nodes, lungs and liver 2. The symptoms may include haematuria, flank mass, weight loss, irregular fever and rarely asymptomatic 5.…”

Section: Discussionmentioning

confidence: 99%

“…Primitive neuroectodermal tumours (PNETs) are rare primary renal tumours 1. It predominantly affects people in second and third decades and has a very short rapid course 2. These are fast growing tumours with non-specific symptoms, most often diagnosed at a very advanced stage with multiple bony and visceral metastases.…”

Section: Ackgroundmentioning

confidence: 99%

Primitive neuroectodermal tumour of the kidney presenting as diplopia secondary to skull metastasis

et al. 2019

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A 20-year-old man presented to the department of neurology with diplopia, occipital headache and right flank pain for 1-week duration. CT of the brain revealed skull metastasis with heterogeneously enhancing dural-based mass lesion at the occipital region. Positron emission tomography revealed tracer avid soft tissue mass involving the upper pole of the right kidney with loss of fat planes with the inferior surface of the liver. Multidisciplinary team approach was discussed. He underwent palliative nephrectomy with lymph nodal mass excision. Biopsy from the renal mass was suggestive of primitive neuroectodermal tumour. He developed progressive liver metastases in spite of adjuvant chemotherapy denoting very aggressive disease.

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Renal Primitive Neuroectodermal Tumor in a Child with Brain Metastasis: A Case Report

Cited by 2 publications

References 6 publications

Primitive neuroectodermal tumor of the kidney: a rare case

Primitive neuroectodermal tumor of the kidney: a rare case

Primitive neuroectodermal tumour of the kidney presenting as diplopia secondary to skull metastasis

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