Renal protective effect of Cinnamon ethanolic extract against induced renal damage by carbon tetrachloride administration in rats

Abstract

One of the most dangerous environmental contaminants is carbon tetrachloride (CCl4) that induces oxidative stress damage in various pathophysiological situations. It's critical to find a potent antioxidant that can reverse CCl4-induced kidney damage. Therefore, the aim of this study was to investigate the efficacy of cinnamon ethanolic extract (CE) to modulate the kidney damage induced by CCl4. The CCl4 was given intraperitoneally twice a week for four weeks as a positive kidney toxic agent at a dose of 0.5 mL/kg. Compared to normal group, CCl4 increased significantly MDA level and decreased significantly both SOD and GSH levels whereas, CE significantly decreased MDA level and increased both SOD as well as GSH levels relative to CCl4 group. CCl4 also led to increase in tumor necrosis factor alpha (TNF-α), beta-2 microglobulin (β2-MG) and kidney injury molecule-1(KIM-1) which indicated the nephrotoxicity induced by CCl4. Based on its strong antioxidant activity and its phenolic and terpenoid contents, CE significantly decreased oxidative damage and pro-inflammatory markers compared to CCl4 treated group.