Renal-Protective Effects and Potential Mechanisms of Traditional Chinese Medicine after Ischemia-Reperfusion Injury

Liu, Demin; Tang, Songling; Gan, Lu; Cui, Wei

doi:10.1155/2021/5579327

Cited by 12 publications

(9 citation statements)

References 28 publications

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“…With the progress of medical technology and the upgrading of management system, we can continuously obtain high health management quality. Foreign studies believe that [ 3 , 17 ] PDCA can greatly improve the standardization of hand hygiene and the qualified rate of disinfection and sterilization in the operating room, which is consistent with the conclusion of this study. Domestic research by Sun shujun [ 3 , 14 , 18 ] showed that the implementation of hand hygiene management based on PDCA can improve the awareness and compliance of hand hygiene knowledge of operating room nurses and is of great value in reducing operating room infection.…”

Section: Discussionsupporting

confidence: 91%

Evaluation of the Effect of PDCA in Hospital Health Management

Qiu

2021

Journal of Healthcare Engineering

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PDCA plays a very important role in the hygienic management of hospital operating rooms. Before the PDCA management from February 2018 to February 2019, routine hygiene management in the operating room was adopted; after the PDCA management from February 2018 to February 2019, PDCA cycle management was adopted. 500 surgical patients were randomly selected from both groups. We compare the quality control checklist scores of hand hygiene management, environmental hygiene management, medical waste management, and disinfection and isolation management in the routine group and the PDCA group. We also compared the detection rate of pathogenic bacteria in surgical incisions of the routine group and the PDCA group and the infection rate of various surgical incisions, air samples, surface samples, disinfectants, and sterilization rates of sterile items. The PDCA group’s hand hygiene management score, environmental hygiene management score, medical waste management score, and disinfection and isolation management score were higher than those in the conventional group ( P < 0.05 ). The detection rate of pathogenic bacteria in the PDCA group, the infection rate of type I, type II, and type III incisions, and the total infection rate of surgical incisions were lower than those in the conventional group, and the difference was statistically significant ( P < 0.05 ). The qualified rate of air samples and surface samples in the PDCA group was higher than that in the conventional group ( P < 0.05 ), and the difference in the qualified rate of disinfectants and sterile items between the two groups was not statistically significant ( P > 0.05 ). The hygiene management of the operating room adopts PDCA sustainable improvement management measures to effectively increase the qualification rate of disinfection and sterilization, reduce the detection rate of pathogenic bacteria and infection rate of surgical incisions, and strengthen the management quality of hand hygiene, environmental hygiene, medical waste, and disinfection and isolation.

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Section: Discussionsupporting

confidence: 91%

Evaluation of the Effect of PDCA in Hospital Health Management

Qiu

2021

Journal of Healthcare Engineering

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“…Due to the ethical, legal, political, and administrative barriers associated with data sharing, it is difficult to merge data from multiple companies. Manuel proposed a distributed method of data extraction [8]. Distributed learning is defined as learning from data without leaving the hospital.…”

Section: 1mentioning

confidence: 99%

Evaluation System of Smart Logistics Comprehensive Management Based on Hospital Data Fusion Technology

Yao

Wang

Ming-liang

et al. 2022

Journal of Healthcare Engineering

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With the acceleration of the informatization process, but because of the late start of the informatization construction of logistics management, the current digital system construction of logistics management has not been popularized, and the intelligent logistics integrated management evaluation system is also extremely lacking. In order to solve the lack of existing intelligent logistics comprehensive management evaluation system, this paper introduces the research of intelligent logistics comprehensive management evaluation system based on hospital data fusion technology. This paper analyzes and utilizes the Kalman filter and adaptive weighted data fusion technology in data fusion technology and then analyzes the evaluation index and system design principles of the intelligent logistics comprehensive management evaluation system and then designs the application layer from the application layer. Design the application layer from the application layer. Then design the framework of the intelligent logistics comprehensive management evaluation system at the network layer and the data layer. The system is finally tested, and the test results show that the evaluation accuracy of the system reaches 80%.

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“…Research has revealed that traditional Chinese medicine monomers and gene knockout technology can improve LPS-induced multiple organ dysfunction, including heart, lung, brain, kidney, and other essential organs [ 11 ]. Both berberine and artesunate can protect against acute lung injury caused by LPS [ 12 , 13 ]. Concurrently, curcumin can effectively improve LPS-induced acute kidney injury [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Puerarin protects against sepsis-induced myocardial injury through AMPK-mediated ferroptosis signaling

Zhou

Zhang

Chen

et al. 2022

Aging

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Objective: Research suggests that Puerarin may protect against sepsis-induced myocardial damage. However, the mechanisms responsible for Puerarin’s cardioprotective effect remain largely unclear. In this study, our objective is to investigate the role of Puerarin-induced AMPK-mediated ferroptosis signaling in protecting myocardial injury. Methods: 48 male Sprague-Dawley rats were randomly divided into four groups: control group, LPS group, LPS + Pue group, LPS + Pue + Era (Erastin, ferroptosis activator) group, or LPS + Pue + CC (compound C, AMPK inhibitor) group. During the experiment, cardiac systolic function indexes and myocardial histopathological changes were monitored. The serum levels of myocardial injury marker enzyme, inflammatory response related marker enzyme, and oxidative stress related-marker enzyme were measured with ELISA. Apoptotic cardiomyocytes, the iron content in myocardial tissue, apoptosis-related proteins, AMPK, and ferroptosis-related proteins were determined. Results: Puerarin inhibited the myocardial injury induced by LPS. The cardioprotective effects of Puerarin decreased after adding ferroptosis-activating compound Erastin. The protein expression levels of GPX4 and ferritin were down-regulated, whereas ACSL4, TFR, and heart iron content were up-regulated in LPS + Pue + Era group compared with LPS+Pue group. A significant difference was identified between LPS + Pue + Era group and LPS + Pue group in P-AMPK and T-AMPK levels. Meanwhile, after providing CC, P-AMPK/T-AMPK was significantly reduced, the protein expression levels of GPX4 and ferritin were down-regulated. ACSL4, TFR, and the heart iron content were up-regulated in LPS + Pue + CC group compared to LPS + Pue group. Conclusions: Puerarin protected against sepsis-induced myocardial injury, and AMPK-mediated ferroptosis signaling played a crucial role in its cardioprotective effect.

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Renal-Protective Effects and Potential Mechanisms of Traditional Chinese Medicine after Ischemia-Reperfusion Injury

Cited by 12 publications

References 28 publications

Evaluation of the Effect of PDCA in Hospital Health Management

Evaluation of the Effect of PDCA in Hospital Health Management

Evaluation System of Smart Logistics Comprehensive Management Based on Hospital Data Fusion Technology

Puerarin protects against sepsis-induced myocardial injury through AMPK-mediated ferroptosis signaling

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