Renal protective effects of chronic exercise and antihypertensive therapy in hypertensive rats with chronic renal failure

Kohzuki, Masahiro; Kamimoto, Masahiro; Wu, Xuemei; Xu, Hong; Kawamura, Takaguki; Mori, Nobuyoshi; Nagasaka, Makoto; Kurosawa, Hájíme; Minami, Naoyoshi; Kanazawa, Masayuki; Saito, Takao; Yoshida, Kazunori

doi:10.1097/00004872-200110000-00024

Cited by 68 publications

(58 citation statements)

References 20 publications

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“…For exercise experiments, the obese Zucker rats received one session of exercise, which consisted of running on a treadmill at 20 m/min, 0% grade for 60 min [9]. Then, the antagonists naloxone and naloxonazine (both from Research Biochemical Inc., Natick, MA) were used to identify the role of opioid µ-receptors.…”

Section: Exercise Programmentioning

confidence: 99%

Mediation of ?-endorphin in exercise-induced improvement in insulin resistance in obese Zucker rats

Su¹,

Chang

Pai³

et al. 2005

Diabetes Metab. Res. Rev.

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Section: Exercise Programmentioning

confidence: 99%

Mediation of ?-endorphin in exercise-induced improvement in insulin resistance in obese Zucker rats

Su¹,

Chang

Pai³

et al. 2005

Diabetes Metab. Res. Rev.

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“…Some previous reports demonstrated no additional benefit of ET combined with drug therapy such as adrenergic receptor blockers and diuretics (24)(25)(26), while others found a synergistic effect of ET when combined with α-adrenoceptor blockade and diuretics in SHR (16). Recent studies have demonstrated that losartan combined with ET improves renal function in renal failure rats (27) and reduces insulin resistance in a rat model of type 2 diabetes mellitus (28).…”

Section: Lf Azevedo Et Almentioning

confidence: 99%

Effects of losartan combined with exercise training in spontaneously hypertensive rats

Azevedo

Brum

Mattos

et al. 2003

Braz J Med Biol Res

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We investigate whether combined treatment with losartan, an angiotensin II receptor blocker, and exercise training (ET) in spontaneously hypertensive rats (SHR) would have an additive effect in reducing hypertension and improving baroreflex sensitivity when compared with losartan alone. Male SHR (8 weeks old) were assigned to 3 groups: sedentary placebo (SP, N = 16), sedentary under losartan treatment (SL, N = 11; 10 mg kg -1 day -1 , by gavage), and ET under losartan treatment (TL, N = 10). ET was performed on a treadmill 5 days/week for 60 min at 50% of peak VO 2 , for 18 weeks. Blood pressure (BP) was measured with a catheter inserted into the carotid artery, and cardiac output with a microprobe placed around the ascending aorta. The baroreflex control of heart rate was assessed by administering increasing doses of phenylephrine and sodium nitroprusside (iv). Losartan significantly reduced mean BP (178 ± 16 vs 132 ± 12 mmHg) and left ventricular hypertrophy (2.9 ± 0.4 vs 2.5 ± 0.2 mg/g), and significantly increased baroreflex bradycardia and tachycardia sensitivity (1.0 ± 0.3 vs 1.7 ± 0.5 and 2.0 ± 0.7 vs 3.2 ± 1.7 bpm/ mmHg, respectively) in SL compared with SP. However, losartan combined with ET had no additional effect on BP, baroreflex sensitivity or left ventricular hypertrophy when compared with losartan alone. In conclusion, losartan attenuates hypertension and improves baroreflex sensitivity in SHR. However, ET has no synergistic effect on BP in established hypertension when combined with losartan, at least at the dosage used in this investigation. Correspondence

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“…It has been postulated that the increases of kinin and NO may dilate renal efferent arterioles to improve the glomerular hypertension by EX. 5 Moreover, Bergamaschi et al reported the dilation of renal efferent arterioles and an improvement of glomerular hypertension by EX in Munich-Wistar rats with CRF. 21 Provided that these findings are also true for WKY rats with CRF, it is conceivable that EX exerts a protective effect on kidneys by improving the glomerular hypertension.…”

Section: Discussionmentioning

confidence: 99%

Combination of Chronic Exercise and Antihypertensive Therapy Enhances Renoprotective Effects in Rats With Renal Ablation

Lü

Kanazawa

Ishida

et al. 2009

American Journal of Hypertension

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Renal protective effects of chronic exercise and antihypertensive therapy in hypertensive rats with chronic renal failure

Abstract: These results suggest that exercise does not worsen renal function and has renal-protective effects in this model of rats. Moreover, the antihypertensive therapy has additional renal-protective effects in this model of rats.

Cited by 68 publications

References 20 publications

Mediation of ?-endorphin in exercise-induced improvement in insulin resistance in obese Zucker rats

Mediation of ?-endorphin in exercise-induced improvement in insulin resistance in obese Zucker rats

Effects of losartan combined with exercise training in spontaneously hypertensive rats

Combination of Chronic Exercise and Antihypertensive Therapy Enhances Renoprotective Effects in Rats With Renal Ablation

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