Renal replacement therapy in cancer patients with acute kidney injury (Review)

Lupuşoru, Mircea; Lupusoru, Gabriela Elena; Ailincăi, Ioana; Frățilă, Georgiana; Andronesi, Andreea; Micu, Elena; Banu, Mihaela; Costea, Radu; Ismail, Gener

doi:10.3892/etm.2021.10296

Cited by 3 publications

(2 citation statements)

References 48 publications

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“…In our study, 5.76% patients experienced postoperative AKI after breast cancer surgery which was in the scope mentioned in previous studies (1.0-31.0%) [27][28][29]. The incidence of AKI in cancer patients was high, which was closely related to their cachexia or renal injury drugs [30]. And another study showed that nonselective NSAIDs (acetaminophen) was not related to the AKI among the patients undergoing surgery for renal carcinoma [31].…”

Section: Discussionsupporting

confidence: 66%

Correlation between perioperative parecoxib use and postoperative acute kidney injury in patients undergoing radical mastectomy: a retrospective cohort analysis

Pang

et al. 2022

BMC Anesthesiol

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Background Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely prescribed drugs worldwide. However, the effect of NSAIDS on postoperative renal function is still unclear. Few studies have assessed the effects of parecoxib on renal function. Our aim is to investigate a correlation between parecoxib and the presence or absence of AKI postoperatively after a breast cancer surgery operation. Methods This was a retrospective cohort study that we performed on our hospitalized database. From January 2012 to August 2021, 3542 female patients undergoing radical mastectomy were enrolled, all data including the patients' information and laboratory results were obtained from electronic medical system. The main outcome was the incidence of AKI postoperatively. AKI was defined in accordance with the KDIGO criteria. Study groups were treated with or without parecoxib. Univariable and multivariable logistic regression analyses were performed. Results In our study, about 5.76% experienced AKI. The incidence rate of postoperative AKI (3.49%) within 7 days in the parecoxib group was lower than that in the control group (6.00%, P = 0.05). Compared to the control group, the AKI’s incidence was reduced by 49% (OR = 0.46; 95%CI 0.27–0.97) in parecoxib group in multivariable logistic regression analysis. There was a reduction in the incidence of postoperative AKI in other three subgroups: preoperative eGFR < 90 mL/min·1.73/m2 (OR = 0.52; 95%CI 0.27–0.97), blood loss < 1000 ml (OR = 0.48; 95%CI 0.24–0.96) and non-diabetes (OR = 0.51; 95%CI 0.26–0.98). Conclusions Parecoxib was associated with incidence of postoperative acute kidney injury.

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Section: Discussionsupporting

confidence: 66%

Correlation between perioperative parecoxib use and postoperative acute kidney injury in patients undergoing radical mastectomy: a retrospective cohort analysis

Pang

et al. 2022

BMC Anesthesiol

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“…Patients with malignancies are at increased risk of developing acute kidney injury (AKI) due to multiple causes: vomiting related to chemotherapy, nephrotoxicity of antineoplastic drugs, or direct kidney involvement caused by the underlying malignancy or urinary tract obstruction. AKI may be severe enough to eventually require renal replacement therapies, which will increase the morbidity and mortality of these patients [1].…”

Section: Introductionmentioning

confidence: 99%

Tumor Lysis Syndrome: An Endless Challenge in Onco-Nephrology

et al. 2022

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Tumor lysis syndrome (TLS) is a common cause of acute kidney injury in patients with malignancies, and it is a frequent condition for which the nephrologist is consulted in the case of the hospitalized oncological patient. Recognizing the patients at risk of developing TLS is essential, and so is the prophylactic treatment. The initiation of treatment for TLS is a medical emergency that must be addressed in a multidisciplinary team (oncologist, nephrologist, critical care physician) in order to reduce the risk of death and that of chronic renal impairment. TLS can occur spontaneously in the case of high tumor burden or may be caused by the initiation of highly efficient anti-tumor therapies, such as chemotherapy, radiation therapy, dexamethasone, monoclonal antibodies, CAR-T therapy, or hematopoietic stem cell transplantation. It is caused by lysis of tumor cells and the release of cellular components in the circulation, resulting in electrolytes and metabolic disturbances that can lead to organ dysfunction and even death. The aim of this paper is to review the scientific data on the updated definition of TLS, epidemiology, pathogenesis, and recognition of patients at risk of developing TLS, as well as to point out the recent advances in TLS treatment.

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Haemodialysis Patients with Type 2 Diabetes Mellitus and COVID-19: An Observational Study

Văcăroiu¹,

Feier²,

Géorgescu³

et al. 2023

RJMM

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Background and Objectives: Chronic Kidney Disease (CKD) affects 6,7% of the adult population in Romania and is associated with high morbidity. About one out of three adults with diabetes has kidney disease. According to current literature data, the prevalence of diabetes is very high, up to 11,6%, of whom 2,4% had undiagnosed diabetes, and is the leading cause of kidney damage and the need for renal replacement therapy (RRT). COVID-19 has brought with it a lot of unanswered questions, regarding the risk factors, the disease evolution, and the treatment possibilities. It became clear that diabetic kidney disease (DKD) is among the independent risk factors that predict unfavorable outcomes upon SARS-CoV-2 infection, so we aimed to evaluate the characteristics of diabetic and non-diabetic dialyzed patients, COVID-19 positive. Materials and Methods: It is an observational, single-center study that analyzed type 2 diabetes mellitus and non–diabetic patients in maintenance hemodialysis hospitalized for SARS CoV-2 infection. Results: A total of 101 adult dialyzed patients were admitted with a SARS-CoV-2 RT-PCR positive test, out of which 42 had a long history of diabetes mellitus type 2 and 59 of them have been known with other etiologies of CKD. Hypertension and heart disease were the most commonly associated comorbidities. Inflammatory markers and anemia were significantly increased in diabetic patients compared to non-diabetic. Conclusions: We found that anemia was more severe in patients COVID-19-positive MHD T2DM patients.

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Renal replacement therapy in cancer patients with acute kidney injury (Review)

Cited by 3 publications

References 48 publications

Correlation between perioperative parecoxib use and postoperative acute kidney injury in patients undergoing radical mastectomy: a retrospective cohort analysis

Correlation between perioperative parecoxib use and postoperative acute kidney injury in patients undergoing radical mastectomy: a retrospective cohort analysis

Tumor Lysis Syndrome: An Endless Challenge in Onco-Nephrology

Haemodialysis Patients with Type 2 Diabetes Mellitus and COVID-19: An Observational Study

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