Renal Resistance Trend During Hypothermic Machine Perfusion Correlates With Preimplantation Biopsy Score in Transplantation of Kidneys From Extended Criteria Donors

Bissolati, Massimiliano; Cerchione, Raffaele; Terulla, Alessia; Corsini, C.; Lee, Yong Ha; Secchi, Antonio; Socci, C.

doi:10.1016/j.transproceed.2021.03.036

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…Indeed, hypothermic kidney pumps have allowed for organ temperature and flow dynamics tracking [29] . Liver perfusion devices also provide laboratory data such as blood gas measurements, temperature, and mean arterial pressure [30] . However, there remains an unmet need for more integrated and comprehensive systems that incorporate measurements of physiologic parameters and environmental stressors on donor organs between explant and implant.…”

Section: Discussionmentioning

confidence: 99%

Transport-Associated Vibrational Stress Triggers Drug-Reversible Apoptosis and Cardiac Allograft Failure in Mice

Lee

Gavzy

Jang

et al. 2023

IEEE J. Transl. Eng. Health Med.

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Increasingly complex and long-range donor organ allocation routes coupled with implementation of unmanned aerial vehicles (UAVs) have prompted investigations of the conditions affecting organs once packaged for shipment. Our group has previously demonstrated that different modes of organ transport exert unique environmental stressors, in particular vibration. Using a mouse heart transplant model, we demonstrated that vibrational forces exert tangible, cellular effects in the form of cardiomyocyte apoptosis and cytoskeletal derangement. Functionally, these changes translated into accelerated allograft loss. Notably, administration of an apoptosis inhibitor, Z-VAD-FMK, helped to ameliorate the detrimental cellular and functional effects of mechanical vibration in a dose-dependent manner. These findings constitute one of the first reports of the negative impact of transit environment on transplant outcomes, a contributing mechanism underpinning this effect, and a potential agent to prophylax against this process. Given current limitations in measuring donor organ transit environments in situ, further study is required to better characterize the impact of transport environment and to potentially improve the care of donor organs during shipment. Clinical and Translational Impact Statement: We show that apoptosis inhibitor, Z-VAD-FMK, ameliorated transport-related vibrational stress in murine heart transplants, which presents a potential therapeutic or preservation solution additive for future use in transporting donor organs.

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Section: Discussionmentioning

confidence: 99%

Transport-Associated Vibrational Stress Triggers Drug-Reversible Apoptosis and Cardiac Allograft Failure in Mice

Lee

Gavzy

Jang

et al. 2023

IEEE J. Transl. Eng. Health Med.

View full text Add to dashboard Cite

show abstract

“…As previously demonstrated in the kidney, MP plays a role in modulating the vascular resistances of the organ prior to transplantation. For instance, HMP tends to reduce vascular renal resistances during perfusion in kidneys 36 and as a result of HMP reconditioning effect, the grafts show better outcomes and a lower rate of delayed graft failure (DGF) 37 , especially in ECDs 38,39 and DCDs 40 organs. It is not proved yet if MP reduce intratissue resistance in the human uterus graft, however this would represent an improvement that should not be underestimated for an organ with high resistance, lowering blood stasis and improving tissue perfusion.…”

Section: Uterus Physiologic Perfusionmentioning

confidence: 99%