Renal resistive indexes and some renal functions in liver cirrhotic children

Aydoğdu, Sema; Akil, İpek; Akil, Talha; Kabasakal, Caner; Killi, Refik; Mır, Sevgı; Yağcı, Raşit Vural

doi:10.1111/j.1442-200x.2004.01826.x

Cited by 7 publications

(3 citation statements)

References 17 publications

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“…Urinary NAG was significantly elevated in the MHRS model in the present study reflecting tubular dysfunction and kidney parenchymal damage as reported by Skálová (2005). In agreement with this result, high urinary NAG was reported in infants with liver cirrhosis (Aydogdu et al, 2004) pointing to an occurrence of renal dysfunction and HRS. The plasma albumin level was reduced significantly in MHRS rats in the present study which confirms the work of García-Martínez et al (2013), who showed that not only albumin concentration but also albumin function is reduced in liver failure.…”

Section: Discussionsupporting

confidence: 92%

Evaluation of the therapeutic effect of <em>Nigella sativa</em> crude oil and its blend with omega-3 fatty acid-rich oils in a modified hepatorenal syndrome model in rats

et al. 2015

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SUMMARY:In the present study, the hepato and reno-protective effect of Nigella sativa crude oil and its binary blend with omega-3 fatty acid-rich oils (fish and flaxseed oils) was studied in a modified hepatorenal syndrome model (MHRS) in rats. MHRS was induced through feeding a high fructose diet followed by an intraperitoneal injection of galactosamine hydrochloride. Nigella oil and its different blends were given as a daily oral dose to MHRS rats. Two control groups of MHRS and normal healthy rats were run. Different biochemical and nutritional parameters were assessed. The induction of MHRS produced liver and kidney dysfunction, and elevated oxidative stress, an inflammatory biomarker, endothelin 1, and plasma cholesterol. Reduced plasma high density lipoprotein cholesterol, albumin and Ca and elevated urinary N-acetyl-β-D-Glucosaminidase and liver fats were noticed. The administration of Nigella crude oil that originally had 0.2% total omega-3 fatty acids or its blend with fish oil (17.9% omega-3) or flaxseed oil (42.1% omega-3) significantly improved all biochemical parameters of MHRS. There was no significant difference in the biochemical parameters among the different oil treated groups regardless of the omega-3 fatty acid content. This may point out to the potential profound effect of the volatile oil fraction of Nigella crude oil which may compensates for its low omega-3 content. KEYWORDS: Hepatorenal syndrome; Nigella crude oil; Oil blends; Omega-3 fatty acidsRESUMEN: Evaluación del efecto terapéutico del aceite crudo de Nigella sativa y su mezcla con aceites ricos en ácidos grasos omega-3 en un modelo de síndrome hepatorenal modificado en ratas. En el presente estudio, el efecto hepato-y reno-protector de aceites crudos de Nigella sativa y su mezcla binaria con aceites ricos en ácidos grasos omega-3 (pescado y aceites de linaza) fue estudiado en un modelo modificado de síndrome hepatorenal (MHRS) en ratas. MHRS fue inducido a través de la alimentación de una dieta alta en fructosa seguido de la inyección intraperitoneal de clorhidrato de galactosamina. Diferentes aceites fueron suministrados como dosis oral diaria a ratas con MHRS. Se realizaron dos grupos de control de MHRS y ratas sanas normales. Se evaluaron diferentes parámetros bioquímicos y nutricionales. La inducción de la MHRS produce disfunción hepática y renal, elevado estrés oxidativo y biomarcadores inflamatorios, endotelina 1, y colesterol en plasma. Se observó una reducción del colesterol plasmatico de lipoproteínas de alta densidad, albúmina y Ca, elevación en orina de N-acetil-β-D-glucosaminidasa y de la grasa del hígado. La administración de aceite crudo de Nigella que tiene un 0,2% de ácidos grasos omega-3 totales o su mezcla con aceite de pescado (17,9% de omega-3) o aceite de linaza (42,1% de omega-3) mejoró significativamente todos los parámetros bioquímicos de MHRS. No hubo diferencia significativa en los parámetros bioquímicos entre los diferentes grupos tratados con los aceites ensayados independientemente del contenido de áci...

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Section: Discussionsupporting

confidence: 92%

Evaluation of the therapeutic effect of <em>Nigella sativa</em> crude oil and its blend with omega-3 fatty acid-rich oils in a modified hepatorenal syndrome model in rats

et al. 2015

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“…High urinary NAG was found in patients with glycogen storage disease (39) and in children with iron overload in beta-thalassaemia major (45), in patients with Wilson's disease (70), in children with liver cirrhosis (7), with Lowe's syndrome (38) and in children with familial Mediterranean fever (4).…”

Section: Various Diseasesmentioning

confidence: 99%

The Diagnostic Role of Urinary N-Acetyl-β-D-glucosaminidase (NAG) Activity in the Detection of Renal Tubular Impairment

Skálová

2005

Acta Med. (Hradec Kralove, Czech Repub.)

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The kidney function can be assessed by a number of methods. The urinary excretion of enzymes, in particular N-acetyl-β-D-glucosaminidase (NAG), is considered a relatively simple, cheap, fast and non-invasive method in the detection and follow-up of renal tubular function under various conditions. The determination of urinary NAG provides a very sensitive and reliable indicator of renal damage, such as injury or dysfunction due to diabetes mellitus, nephrotic syndrome, inflammation, vesicoureteral reflux, urinary tract infection, hypercalciuria, urolithiasis, nephrocalcinosis, perinatal asphyxia, hypoxia, hypertension, heavy metals poisoning, treatment with aminoglycosides, valproate, or other nephrotoxic drugs. This paper gives an overview of the current use of urinary NAG in the detection of renal injury.

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“…LC is accompanied by hemodynamic changes which eventually lead to vasoconstriction of the renal vessels with marked decrease in renal perfusion and glomerular filtration rate (GFR), azotemia, and increased serum creatinine concentration 2,8,9 . This impairment of renal function in liver cirrhosis is known as hepatorenal syndrome (HRS), the development of which has poor prognosis and is associated with mortality rates approaching 100% 10 . Moreover, the only effective treatment is liver transplantation; 11 hence, early detection and management is essential for patient survival.…”

Section: Introductionmentioning

confidence: 99%

Renal arterial resistance index among subjects with liver cirrhosis in a Nigerian population

Onwuka

Ayoola

Adekanle

et al. 2021

J of Clinical Ultrasound

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Purpose To describe the relationship between renal artery resistance index (RARI) and liver function based on Child‐Pugh system among patients with liver cirrhosis (LC) in Southwest Nigeria. Methods About 50 patients with LC and 50 controls were consecutively recruited into this prospective comparative case control study. Each LC patient was classed based on Child‐Turcotte‐Pugh (CTP) system after relevant tests. Subjects underwent abdominal ultrasonography with triplex Doppler examination of the right kidney to obtain RARI. Results About 50 cirrhotic and 50 controls completed the study. Age range of cirrhotic subjects was 19‐69 years (mean ± SD = 47.5 ± 13.3) while that of controls was 18‐69 years (46.9 ± 15.0). RARI was higher (P = <.001) in patients with LC (0.68) than in controls (0.57). RARI was also significantly higher (P = <.001) in cirrhotic subjects in CTP class C (0.72) than in those in classes B (0.66) and A (0.58). Additionally, RARI showed significant correlation with CTP total score (r = .662; P = <.001), serum bilirubin (r = .297; P = .036), serum albumin (r = −.494; P = <.001), serum sodium (r = −.369; P = .008), Model for End Stage Liver Disease (MELD) score (r = .316; P = .026) and MELD‐Na score (r = .470; P = .001). RARI showed no significant relationship with serum creatinine (r = .110; P = .445) and blood urea nitrogen (r = .112; P = .437). Conclusion Liver cirrhosis is associated with renovascular changes which manifest as increased resistance in the renal arteries. RARI is a useful noninvasive tool for the assessment of these changes and should be done routinely in the evaluation of patients with LC.

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Renal resistive indexes and some renal functions in liver cirrhotic children

Cited by 7 publications

References 17 publications

Evaluation of the therapeutic effect of <em>Nigella sativa</em> crude oil and its blend with omega-3 fatty acid-rich oils in a modified hepatorenal syndrome model in rats

Evaluation of the therapeutic effect of <em>Nigella sativa</em> crude oil and its blend with omega-3 fatty acid-rich oils in a modified hepatorenal syndrome model in rats

The Diagnostic Role of Urinary N-Acetyl-β-D-glucosaminidase (NAG) Activity in the Detection of Renal Tubular Impairment

Renal arterial resistance index among subjects with liver cirrhosis in a Nigerian population

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