Renal Response to an Oral Sodium Load in Newborn Full Term Infants

Aperia, Anita; Broberger, O.; Thodenius, Kersti; Zetterström, Rolf

doi:10.1111/j.1651-2227.1972.tb15965.x

Cited by 103 publications

(33 citation statements)

References 22 publications

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“…It has been well established that the kidney of the new-born animal does not respond as well as that of the adult to a sodium load (Aperia, Broberger, Thodenius & Zetterstrom, 1972;Baker & Solomon, 1976;Kleinman & Reuter, 1974;McCance & Widdowson, 1957). For example, when new-born dogs were given an i.v.…”

Section: Introductionmentioning

confidence: 99%

Effect of amiloride on the renal response to saline expansion in new‐born dogs.

Banks¹,

Kleinman²

1978

The Journal of Physiology

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SUMMARY1. The renal effects of amiloride were studied in twenty-six new-born and nine adult dogs, with and without saline expansion.2. Without saline expansion, amiloride inhibited more sodium reabsorption (normalized to GFR) in puppies than in adults (5.95 vs. 2-18 ,tequiv/ml. GFR, P < 0.01).Amiloride inhibited sodium reabsorption more in saline expanded than in nonexpanded puppies (9.39 vs. 5.95 #sequiv/ml. GFR, P < 0.01) but there was no difference between expanded and non-expanded adults.3. Saline expansion by itself increased fractional sodium excretion (CNa/GFR) more in the adult than in the puppy (0-071 vs. 0-019, P < 0-01). During amiloride inhibition, saline expansion increased CNa/GFR to 0*045 in the puppy (compared to 0X019 in the nonamiloride inhibited puppy) but saline expansion increased CNa/GFR to the same degree in the amiloride as in the non-amiloride inhibited adult. 4. In all puppies amiloride inhibited more sodium reabsorption than potassium secretion and there was poor correlation between the degree of inhibition of sodium reabsorption and potassium secretion for both the puppy (r = 0.14) and the adult (r = 0.05).5. Assuming that amiloride acts by inhibiting sodium reabsorption and potassium secretion in the late distal and cortical collecting tubules, these results support the conclusion that in these regions of the nephron of the new-born dog (a) a greater fraction of the filtered sodium is reabsorbed than in the adult and (b) increased fractional sodium reabsorption is responsible, in part, for the attenuated natriuretic response to saline expansion.

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Section: Introductionmentioning

confidence: 99%

Effect of amiloride on the renal response to saline expansion in new‐born dogs.

Banks¹,

Kleinman²

1978

The Journal of Physiology

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“…aorta which seems to be relevant for the change in blood flow, is similar in adult rabbits and newborn infants. Furthermore, the relatively low RBF, possible hypoxemia, and the higher vulnerability of newborn kidneys [3] might present additional predisposing factors for thrombus formation in the neonate. Our study suggests that RBF is not altered by a high position of aortic catheters and that, therefore, other reasons than RBF should decide on the placement of these catheters.…”

Section: Discussionmentioning

confidence: 99%

Renal blood flow in high and low positions of aortal catheter in rabbits

Uhari¹,

Tarkka²,

Koskinen³

1981

Journal of Perinatal Medicine

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“…7 This characteristic of neonatal renal function is favorable during active growth and may be maintained by high circulating levels of aldosterone. 6 This functional hyperaldosteronism is probably a result of a blunted negative feedback control on renin production.…”

Section: See Related Article On Page 335mentioning

confidence: 99%

“…6 An increase in microbial exposure and infections has been proposed as an explanation for these findings. 7 …”

Section: See Related Article On Page 335mentioning

confidence: 99%

“…6 This coincides with the transport of large quantities of sodium chloride and obligate water into the fetus from the mother ensuring a positive water and electrolyte balance for growth. 6,7 However, studies in fetal lamb preparations suggest that the by mid-gestation the fetus will respond to extracellular volume expansion with modulation of these high rates of proximal and distal tubular reabsorption. 8 …”

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confidence: 99%

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