Renal Responses to Acetylcholine.

Lavender, A. R.; Aho, Impi; Pullman, Theodore N.

doi:10.3181/00379727-119-30328

Cited by 12 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effects of close-arterial infusions of acetylcholine into the kidney have been reported by many workers. A low concentration of acetylcholine produces renal vasodilatation in dogs (Cook et al, 1950;Pilkington et al, 1965;Pinter et al, 1964;Vander, 1964;Lavender et al, 1965;Earley & Friedler, 1965;Harvey, 1966;McGiff et al, 1967;Martino & Earley, 1968;Cohen & Carter, 1967;Kiil, Kjekshus & Lsyning, 1969;Stinson et al, 1969;Auckland & Lsyning, 1970;MacFarland, 1970), in man (Breckenridge et al, 1960Dollery et al, 1965), in cats (Astrom et al, 1964 and in the renal portal system of chicken (Parmelee & Carter, 1968;May & Carter, 1970). A medium concentration causes a biphasic change in rats (Astrom et al, 1964;McGiff et al, 1967;Heller & Novakova, 1969).…”

Section: Discussionmentioning

confidence: 99%

“…Of the common neurotransmitters, noradrenaline (and adrenaline) produce renal vasoconstriction and diuresis following cessation of intravenous infusion due to an indirect action (Liang & Yang, 1972). Close-arterial infusion of moderate doses of acetylcholine generally causes increases in renal blood flow and in NaCl excretion in animals (Cook, Hamborger & Green, 1950;Pinter, O'Morchoe & Sikand, 1964;Vander, 1964;Lavender, Aho & Pullman, 1965;Dollery, Goldberg & Pentecost, 1965;Martino & Earley, 1968;McNay & Abe, 1970;Hayslett et al, 1970;Martinez-Maldonado et al, 1972), and larger doses of acetylcholine causes decreases in renal blood flow, urine volume and NaCl excretion (htrom, Crafoord & Samelius-Broberg, 1964;Vander, 1964;McGiff, Burn & Blumenthal, 1967;Conchoa & Norris, 1968;Astrom & Crafoord, 1968;Hayslett et al, 1970). Close-arterial infusion of prostaglandins into the kidney causes increases in renal blood flow, urine volume and excretion of NaCl (Johnston, Herzog & Lauler, 1967;Carriere, Friborg & Guay, 1971 ;Martinez-Maldonado et al, 1972).…”

mentioning

confidence: 99%

See 1 more Smart Citation

A possible sympathetic cholinergic mechanism in the renal reflex elicited by stimulation of abdominal viscera in the dog

1975

Clin Exp Pharma Physio

View full text Add to dashboard Cite

1. Isolated blood-bathed tissues which were superfused with renal venous blood during various manipulations of the visceral organs of dogs showed no detectable pharmacologically active substances, except a noradrenaline-like substance which was liberated under some conditions of manipulation. 2. An acetylcholine-like substance was liberated into renal venous blood during experimental manipulation of visceral organs in dogs during infusion of physostigmine; the acetylcholine activity was detected with the dorsal muscle of the leech. 3. The amount of liberated acetylcholine-like substance depended on the strength of visceral stimulation as judged by the changes in the hepatic portal venous pressure. Strong reflex stimulation produced the release not only of acetylcholine but also of noradrenaline. 4. Physostigmine augmented and prolonged the reflexly induced renal vasodilator and diuretic responses, and these were abolished by atropine. It was suggested that the reflex involves a cholinergic nervous mechanism. 5. In some dogs there was a high output of acetylcholine from the kidney during visceral stimulation, and this was accompanied by a decrease in urine flow. The reason was not known. 6. Prostaglandin E1 administered into the renal artery produced similar vasodilator and diuretic responses to acetylcholine, but the onset of the effects were slower and they persisted longer than those produced by acetylcholine.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

A possible sympathetic cholinergic mechanism in the renal reflex elicited by stimulation of abdominal viscera in the dog

1975

Clin Exp Pharma Physio

View full text Add to dashboard Cite

show abstract

“…Though the renal vasodilator effect of ACh is well known (20)(21)(22), constriction of the renal blood vessels produced by ACh has received scant attention (23). Under the present experimental conditions, 1 mg of ACh administered into the renal artery produced vasoconstriction ( Figs.…”

Section: Discussionmentioning

confidence: 99%

Role of Acetylcholine in the Renal Vasoconstrictor Response to Sympathetic Nerve Stimulation in the Dog

McGiff

Burns

Blumenthal

1967

Circulation Research

View full text Add to dashboard Cite

The renal blood vessels were studied for a cholinergic determinant of their response to renal nerve stimulation. In dogs anesthetized with morphine and chloralose, control values were: mean aortic blood pressure 147 ± 4 mm Hg, renal blood flow 257 ± 12 ml/min. Acetylcholine (ACh) in 1-, 10-and 100-^tg doses (all drugs given into the renal artery) increased renal blood flow, whereas 1000 fig of ACh reduced renal blood flow by 35%. After atropine and physostigmine, 1 /xg of ACh did not alter renal blood flow, while 10, 100 and 1000 /xg of ACh reduced renal blood flow by 6, 40 and 72%, respectively. After reserpine pretreatment, ACh in all doses increased renal blood flow (range of the means from 20 to 30%). The vasoconstrictor action of ACh was also blocked by phentolamine, guanethidine and hexamethonium. The renal vasoconstrictor response to renal nerve stimulation was blocked by guanethidine, but not by hexamethonium. These observations suggest that hexamethonium opposes ACh by barring its entry into the nerve terminals, whereas guanethidine blocks the intraneuronal release of norepinephrine by ACh. The vasoconstrictor response to nerve stimulation was reduced by atropine and augmented by physostigmine. Hemicholinium, which blocks the synthesis of ACh, attenuated the renal vasoconstriction produced by nerve stimulation. The results suggest that ACh may function in the canine kidney to liberate norepinephrine during activity of the sympathetic nerves.

show abstract

“…Cholinergic drugs injected into the renal artery of the dog have been shown to produce saluresis by a direct renal action (Vander, 1964;Pinter, O'Morchoe & Sikand, 1964;Lavender, Aho & Pullman, 1965;Williams, Pearson & Carter, 1965). This saluresis is effected chiefly by increasing the tubular rejection fraction of the filtered load of sodium (Williams et a)., 1965).…”

mentioning

confidence: 99%

Analysis of Direct Renal Actions of Alpha and Beta Adrenergic Stimulation Upon Sodium Excretion Compared to Acetylcholine

Pearson

Williams

1968

British Journal of Pharmacology and Chemotherapy

View full text Add to dashboard Cite

Renal Responses to Acetylcholine.

Abstract: Int. P h a r m d y n . , in press. v139, 54. 9. Coleman, B., Glaviano, V. V., Science, 1962, 10. €Eft, H., Strawitz, J. G., Am.

Cited by 12 publications

References 0 publications

A possible sympathetic cholinergic mechanism in the renal reflex elicited by stimulation of abdominal viscera in the dog

A possible sympathetic cholinergic mechanism in the renal reflex elicited by stimulation of abdominal viscera in the dog

Role of Acetylcholine in the Renal Vasoconstrictor Response to Sympathetic Nerve Stimulation in the Dog

Analysis of Direct Renal Actions of Alpha and Beta Adrenergic Stimulation Upon Sodium Excretion Compared to Acetylcholine

Contact Info

Product

Resources

About