Renal Segmental Hypoplasia, Ask-Upmark Kidney, in a Patient with Adult-onset Hypertension

Sugimoto, Toshiro; Tanaka, Yuki; Nitta, Norihisa; Uzu, Takashi; Nishio, Yoshihiko; Kashiwagi, Atsunori

doi:10.2169/internalmedicine.45.1858

Cited by 4 publications

(1 citation statement)

References 5 publications

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“…However, since the renal arteries supplying the hypoplastic foci are small and extrarenal vascular anomalies such as fibromuscular dysplasia or renal artery aneurysm occur in 40% of cases, a role for ischemia in the disease process is possible but further supports developmental contributions to the lesions. 22 , 29 , 30 …”

Section: Historical Review Of Renal Hypoplasiasmentioning

confidence: 99%

Renal Hypoplasia, From Grossly Insufficient to Not Quite Enough: Consideration for Expanded Concepts Based Upon the Author’s Perspective With Historical Review

Bonsib

2020

Advances in Anatomic Pathology

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Hypoplasia is defined in the Merriman-Webster dictionary as “a condition of arrested development in which an organ, or part, remains below the normal size, or in an immature state.” The degree of reduced size is not definitional. Renal hypoplasia, however, has historically been defined as a more marked reduction in renal mass such that presentation in childhood is the norm. There are 3 commonly recognized types of renal hypoplasia, simple hypoplasia, oligomeganephronic hypoplasia (oligomeganephronia) and segmental hypoplasia (Ask-Upmark kidney). They have in common a reduction in the number of renal lobes. A fourth type, not widely recognized, is cortical hypoplasia where nephrogenesis is normal but there is a reduction in the number of nephron generations. Recently there has been great interest in milder degrees of reduced nephron mass, known as oligonephronia because of its association with risk of adult-onset hypertension and chronic kidney disease. Since the last pathology review of this topic was published by Jay Bernstein in 1968, an update of the renal pathology findings in renal hypoplasia is provided with a review of 18 new cases. The renal hypoplasias are then framed within the modern concept of oligonephronia, its diverse causes and prognostic implications.

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Section: Historical Review Of Renal Hypoplasiasmentioning

confidence: 99%

Renal Hypoplasia, From Grossly Insufficient to Not Quite Enough: Consideration for Expanded Concepts Based Upon the Author’s Perspective With Historical Review

Bonsib

2020

Advances in Anatomic Pathology

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Renal segmental hypoplasia, Ask-Upmark kidney, in a patient with microalbuminuric hypertensive type 2 diabetes mellitus

Fuke

Sugimoto

Ugi

et al. 2008

Diabetes Research and Clinical Practice

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Ask-Upmark Kidney and Tubulointerstitial Nephritis in a Woman with Severe Renal Failure

et al. 2011

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Ask-Upmark kidney is a rare diagnosis of segmental hypoplasia in pediatric population clinically characterized by severe hypertension potentially treatable with partial to total nephrectomy. Although originally was described only as a congenital anomaly, recent data suggest to be caused by vesicoureteral reflux, either in utero or in early childhood and pyelonephritis. The case we reported indicates that Ask-Upmark kidney should be considered as potential cause of hypertension and renal failure both in children and adults. The renal biopsy is necessary for early diagnosis and may consent to normalize blood pressure with nephrectomy; however, if renal damage is severe and progressive with tubulointerstitial nephritis, surgical management is excluded and renal transplant should be considered.

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Renal Segmental Hypoplasia, Ask-Upmark Kidney, in a Patient with Adult-onset Hypertension

Abstract: (Fig. 1B), narrowed renal arteries with tiny renal arterial branches in the upper part of the left kidney (Fig. 1C), but no renal artery stenosis in either kidney. In the nephrographic phase, the normal parenchymal tissue remained segmentally only in the left kidney (Fig. 1D)

Cited by 4 publications

References 5 publications

Renal Hypoplasia, From Grossly Insufficient to Not Quite Enough: Consideration for Expanded Concepts Based Upon the Author’s Perspective With Historical Review

Renal Hypoplasia, From Grossly Insufficient to Not Quite Enough: Consideration for Expanded Concepts Based Upon the Author’s Perspective With Historical Review

Renal segmental hypoplasia, Ask-Upmark kidney, in a patient with microalbuminuric hypertensive type 2 diabetes mellitus

Ask-Upmark Kidney and Tubulointerstitial Nephritis in a Woman with Severe Renal Failure

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