2021
DOI: 10.3390/vetsci8120314
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Renal Senescence, Telomere Shortening and Nitrosative Stress in Feline Chronic Kidney Disease

Abstract: Kidney tissues from cats with naturally occurring chronic kidney disease (CKD) and adult and senior cats without CKD were assessed to determine whether telomere shortening and nitrosative stress are associated with senescence in feline CKD. The histopathologic assessment of percent global glomerulosclerosis, inflammatory infiltrate, and fibrosis was performed. Senescence and nitrosative stress were evaluated utilizing p16 and iNOS immunohistochemistry, respectively. Renal telomere length was evaluated using te… Show more

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Cited by 3 publications
(4 citation statements)
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“…7,8,30 Senescence plays a role in aging in the feline kidney, as p16-mediated renal senescence is positively correlated with age in cats without CKD. 31 Taken together with our description of the histologic lesions associated with age, these data present evidence for renal aging in cats, and a concern for decreased ability to withstand injury and promote effective repair.…”
Section: Discussionsupporting
confidence: 56%
“…7,8,30 Senescence plays a role in aging in the feline kidney, as p16-mediated renal senescence is positively correlated with age in cats without CKD. 31 Taken together with our description of the histologic lesions associated with age, these data present evidence for renal aging in cats, and a concern for decreased ability to withstand injury and promote effective repair.…”
Section: Discussionsupporting
confidence: 56%
“…Treatments targeting senescent cells and the SASP have broad potential implications in the field of veterinary medicine as the hallmarks of aging ( 6 ) are highly conserved across species ( 227 , 228 ). These hallmarks include DNA damage ( 229 ), telomere shortening ( 230 , 231 ), aberrant proteostasis ( 232 ), epigenetic modifications ( 233 ), altered nutritional signaling ( 234 , 235 ), cell senescence ( 193 , 213 , 215 , 231 , 236 ), stem cell depletion ( 237 ), mitochondrial dysfunction ( 238 , 239 ), and abnormal inflammatory signaling ( 240 , 241 ). Treatment of age-related diseases in veterinary species may further serve to bolster preclinical evidence for use in humans.…”
Section: Discussionmentioning
confidence: 99%
“…Spontaneous chronic kidney disease (CKD) is well-described in cats ( 182 185 ). Feline patients suffering from CKD have renal senescence, telomere shortening, and nitrosative stress in renal cells ( 215 ). With similar pathologic findings to humans ( 216 , 217 ), they represent a naturally occurring model for study of senotherapeutics ( 215 ).…”
Section: Senotherapeutic Potential In Veterinary Speciesmentioning
confidence: 99%
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