Renal solitary fibrous tumor/hemangiopericytoma: computed tomography findings and clinicopathologic features

Yi, Xiaoping; Wang, Jing; Zhang, Youming; Wang, Zixin; Zhang, Zinan; Gong, Guanghui; Liu, Longfei; Wang, Xiang; Liao, Weihua; Zee, Chi‐Shing; Chen, Bihong T.

doi:10.1007/s00261-018-1777-8

Cited by 5 publications

(6 citation statements)

References 26 publications

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“…Primary neoplasms of the renal sinus are rare and can originate from any of the tissue elements present 1. Examples include angiomyolipoma, anastomosing hemangioma, “myxoma,” solitary fibrous tumor, leiomyoma, lymphoma, immunoglobulin (Ig) G4–related disease, and well-differentiated/dedifferentiated liposarcoma 2–9. Myxoid lesions of the renal sinus, in particular, may present a diagnostic challenge because although myxoid liposarcoma occurring in the retroperitoneum is rare,10 well-differentiated liposarcoma with myxoid change is not infrequent in this location, including in perirenal soft tissue 11…”

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confidence: 99%

Myxoid Pseudotumor Involving the Renal Sinus

Hogan

McKenney

Cox

et al. 2022

American Journal of Surgical Pathology

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We describe 33 cases of myxoid pseudotumor involving the renal sinus from 31 patients. Patients included 21 men and 10 women, ages 30 to 95 years. Twenty-seven cases (82%) had an associated malignancy, including urothelial carcinoma of the renal pelvis (22 cases), clear cell renal cell carcinoma (3 cases), urothelial carcinoma of the bladder (1 case), and poorly differentiated carcinoma of uncertain lineage (1 case). The remaining 6 (18%) had no associated malignancy and included 3 nephrectomies for ureteral stricture, 2 ureteropelvic junction repairs, and 1 resection of a “periureteral mass” (subsequently shown to be myxoid pseudotumor). Myxoid pseudotumor was identified by preoperative computed tomography imaging in 2 patients (6%) and identified by the gross dissector in 9 cases (27%). The mean size was 14 mm (range: 5 to 38 mm). All cases had an admixture of adipocytes, myxoid stromal matrix, variable collagenization, and a hypocellular population of bland spindled and stellate stromal cells. No multilobated atypical stromal cells were present. Clinical follow-up was available for 28 patients (90%), ranging from 1 to 132 months (mean: 24.6 mo). No patients had adverse events related to the myxoid pseudotumor. Myxoid pseudotumor of the renal sinus is often associated with a variety of adjacent neoplastic and non-neoplastic conditions and may present as a mass lesion detectable by imaging and/or gross inspection. Awareness of this benign process is important to avoid confusion with a neoplasm, especially liposarcoma.

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confidence: 99%

Myxoid Pseudotumor Involving the Renal Sinus

Hogan

McKenney

Cox

et al. 2022

American Journal of Surgical Pathology

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“… 30 Amonst all stromal cells, CAFs are considered as the most important ones because of their abundance and their strong interaction with cancer cells. 7 , 35 CAFs were proven to promote the invasion and treatment resistance of cancer cells through paracrine and extracellular matrix (ECM) remodeling in many solid tumors including HNSCC, 36 , 37 , 38 , 39 , 40 however, the clinical significance of CAF‐related genes expression remains unclear. In our study, we identified two new HNSCC subtypes based on the 66 CAF‐related genes expression level obtained from TCGA database, while further consensus clustering analysis showed that the patients assigned to the cluster 1 had higher stromal infiltration and worst prognosis than the patients in the cluster 2.…”

Section: Discussionmentioning

confidence: 99%

Cancer associated fibroblast derived gene signature determines cancer subtypes and prognostic model construction in head and neck squamous cell carcinomas

Huang

et al. 2022

Cancer Medicine

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“…The delayed enhancement may be related to the abundance of collagen fibers, which restrict the diffusion of contrast agent within the tumor. 4,20 Lane et al 15 found that MESTK commonly tends to extend into the renal sinus. In our study, 10 subjects (55.5%) have demonstrated SFI, indicating that nephron-sparing surgery is not the best management plan for such tumors compared to those without the SFI.…”

Section: Discussionmentioning

confidence: 99%

“…Gradual enhancement pattern was considered present when the tumor attenuation in the NP was at least 20 Hounsfield units (HU) greater than that in the CMP, 19 while gradual washout pattern was defined when the CT value of the subsequent phase was reduced to less than 20 HU. 20 The degree of enhancement was defined as the difference between the attenuation value of the unenhanced scan and the CMP. A difference higher than 50 HU was classified as marked, between 20 and 50 HU as moderate, and less than 20 HU as weak enhancement.…”

Section: Imaging Analysismentioning

confidence: 99%

Differentiating the clinical and computed tomography imaging features of mixed epithelial and stromal tumors of the kidney to establish a treatment plan

Chen

Liu

et al. 2021

J Applied Clin Med Phys

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To differentiate the clinical features and computed tomography imaging features in the two types of mixed epithelial and stromal tumor of the kidney (MESTK) and to establish a treatment plan for the MESTK types. Methods: Seventeen patients who underwent multidetector computed tomography (MDCT) before surgery and had a pathological diagnosis of MESTK were enrolled. Their clinical information (R.E.N.A.L. nephrometry score (R.E.N.A.L.-NS), radical nephrectomy (RN), partial nephrectomy (PN), etc.) were collected. The radiological features included renal sinus fat invagination (SFI), maximal diameter (MD), capsule and septa of the tumor, etc., were also analyzed. They were divided into two types according to the MD solid /MD tumor ratio (solid type with >60%; cystic type with ≤60%). An independent-sample t-test and Fisher exact test were used to assess the differences between the two groups. Results: MESTKs demonstrated a variable multi-septate cystic and solid components with a delayed enhancement. There were nine patients for solid type and eight patients for cystic type. Compared with solid type, the lesions in cystic type have larger MD (81.00 ± 37.91 vs. 41.22 ± 24.19, p = 0.020), higher R.E.N.A.L.-NS (10.03 ± 0.50 vs. 8.95 ± 1.26, p < 0.001), higher RN (75.00% vs. 22.22%, p = 0.015), larger SFI (87.5% vs. 33.3%, p = 0.05), more septa (100% vs. 0%, p < 0.001), and more capsule (100% vs. 11.1%, p < 0.001). Conclusion:Cystic type MESTK has more hazardous features (such as larger MD, higher R.E.N.A.L.-NS, more RN, greater SFI, multiple septa) compared with solid type, suggesting that RN is more suitable for cystic type and PN for solid type. K E Y W O R D Sclassification, clinical data, mixed epithelial and stromal tumor of the kidney, multidetector computed tomography features, patient management INTRODUCTIONMixed epithelial and stromal tumor of the kidney (MESTK), first identified by Michal and Syrucek, 1 is a rare benign entity with a prevalence of 0.2%-1.6% ofThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Renal solitary fibrous tumor/hemangiopericytoma: computed tomography findings and clinicopathologic features

Cited by 5 publications

References 26 publications

Myxoid Pseudotumor Involving the Renal Sinus

Myxoid Pseudotumor Involving the Renal Sinus

Cancer associated fibroblast derived gene signature determines cancer subtypes and prognostic model construction in head and neck squamous cell carcinomas

Differentiating the clinical and computed tomography imaging features of mixed epithelial and stromal tumors of the kidney to establish a treatment plan

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