Renal Sympathetic Denervation in Rats

Eriguchi, Masahiro; Tsuruya, Kazuhiko

doi:10.1007/978-1-4939-3353-2_5

Cited by 7 publications

(4 citation statements)

References 23 publications

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“…Renal sympathetic denervation of 11-week-old rats was performed by chemical ablation as described previously [20,21]. Briefly, after anesthetizing the rats with pentobarbital (50 mg/kg, i.p.…”

Section: Methodsmentioning

confidence: 99%

Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system

Chen

Sun

et al. 2019

Clinical Science

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Environmental temperature plays a role in the variation of blood pressure. Maternal cold stress could affect the physiological phenotype of the offspring, including blood pressure elevation. In the present study, we found that adult offspring of dams exposed to cold have increased systolic and diastolic blood pressure, and decreased urine volume and sodium excretion, accompanied by increased heart rate and heart rate variability, secondary to increased activity of the sympathetic nervous system. Renal denervation or adrenergic receptor blockade decreased blood pressure and increased sodium excretion. The increase in peripheral sympathetic nerve activity can be ascribed to the central nervous system because administration of clonidine, a centrally acting α2 adrenergic receptor agonist, lowered blood pressure to a greater degree in the prenatal cold-exposed than control offspring. Moreover, these prenatal cold-exposed offspring had hypothalamic paraventricular nucleus (PVN) disorder because magnetic resonance spectroscopy showed decreased N-acetylaspartate and increased choline and creatine ratios in the PVN. Additional studies found that prenatal cold exposure impaired the balance between inhibitory and excitatory neurons. This led to PVN overactivation that was related to enhanced PVN-angiotensin II type 1 (AT1) receptor expression and function. Microinjection of the AT1 receptor antagonist losartan in the PVN lowered blood pressure to a greater extent in prenatal cold-exposed that control offspring. The present study provides evidence for overactive peripheral and central sympathetic nervous systems in the pathogenesis of prenatal cold-induced hypertension. Central AT1 receptor blockade in the PVN may be a key step for treatment of this type hypertension.

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Section: Methodsmentioning

confidence: 99%

Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system

Chen

Sun

et al. 2019

Clinical Science

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“…Our selection of phenol mirrors typical strategies for renal artery denervation, which has demonstrated effects beyond 6 months, comparable to the duration of our model follow-up. 31 , 32 However, some conflicting studies have reported evidence of renal artery neural regeneration. 33 Thus, although our investigation of nerve fiber density indicates persistent local denervation, the potential for aortic sympathetic neural regeneration is not completely known.…”

Section: Discussionmentioning

confidence: 99%

Characterization of a phenol-based model for denervation of the abdominal aorta and its implications for aortic remodeling

Chao,

Dang,

Reddy

et al. 2024

JVS-Vascular Science

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“…Stress was applied by placing the rats in a foot shock box with a metal grid floor for 4 h. The electric current was controlled using an electronic device (0.15 mA, 5-30 s with random current). The rats' renal nerve was surgically denervated under anesthesia with 10% chloral hydrate according to previous reports [22]. Foot shock stress was commenced 1 week after the surgery.…”

Section: Chronic Stress Animal Modelmentioning

confidence: 99%

Role of Renin-Angiotensin System, Renal Nerve System, and Oxidative Stress in Chronic Stress-Induced Renal Expression of Aquaporin-1 in Rats

X¹,

Y²,

Wang³

et al. 2021

austinjnephrolhypertens

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Aims: To investigate the renal aquaporin-1 (AQP1) expression under chronic stress (induced by foot shock) condition and possible mechanisms involved in rats. Methods: The chronic stress model was established in male Sprague Dawley (SD) rats by foot shock for two weeks. Rats were randomly divided into control group, chronic stress group, renal denervation group, renal denervation plus chronic stress group, captopril (an angiotensin I converting enzyme inhibitor, ACEI) plus chronic stress group and tempol (a superoxide dismutase mimetic) plus chronic stress group. Body weight, food intake, water intake, blood pressure and heart rate were monitored. Real-time PCR was used to detect the mRNA level of AQP1 in the renal tissue. Immunohistochemistry stain was used to observe the expression and location of AQP1 in rat kidneys. Results: Chronic stress reduced body weight gain and food intake, while it significantly increased systolic blood pressure and renal expressions of mRNA and protein of AQP1 (P<0.05) as compared with control group. Renal denervation and tempol treatments did not affect stress-induced decreases of body weight gain and food intake. Renal denervation, captopril and tempol treatments decreased systolic blood pressure. Compared with the chronic stress group, mRNA and protein expression of AQP1 was decreased (P<0.05) in renal denervation plus chronic stress group, captopril plus chronic stress group and tempol plus chronic stress group. Conclusion: Chronic stress induces increase of the AQP1 expression in kidney, which is regulated by renal nerve system, renin-angiotensin system and oxidative stress.

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Renal Sympathetic Denervation in Rats

Cited by 7 publications

References 23 publications

Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system

Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system

Characterization of a phenol-based model for denervation of the abdominal aorta and its implications for aortic remodeling

Role of Renin-Angiotensin System, Renal Nerve System, and Oxidative Stress in Chronic Stress-Induced Renal Expression of Aquaporin-1 in Rats

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