Renal Toxicity Following Oral Cholecystography with Oragrafin (Ipodate Calcium)

Harrow, Benedict R.; Winslow, Oliver P.

doi:10.1148/87.4.721

Cited by 9 publications

(5 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oral cholecystographic media have been described as rare causes of renal failure (Seaman et al, 1963 ;Harrow and Winslow, 1966). One such agent (Bunamiodyl) was withdrawn from the market after several reports of renal failure following its use (Seaman et al, 1963).…”

Section: Discussionmentioning

confidence: 99%

Renal failure after cholangiography.

Craft¹,

Swales²

1967

BMJ

View full text Add to dashboard Cite

Pregnancy in Young Primigravidae-Utian MEDBRITJISOURNA of pre-eclampsia. Only prompt and active treatment prevented a higher incidence of eclampsia. The single case of eclampsia occurred in a 16-year-old unbooked patient who presented at term with a blood pressure of 200/150 mm. Hg, no significant increase in weight, and no albumin in the urine. It became apparent in the management of these young patients that proteinuria was not a constant feature and its absence should not lull one into a false sense of complacency. Increase in Prematurity Rate.-It has been shown in this study that young primigravidae have an increased tendency to begin spontaneous labour before term. These findings are in marked contrast to those of Clough (1958), who reported on 175 young primigravidae and stated that these patients went beyond the expected date of confinement more often than older primigravidae. Both Bochner (1962) and Stearn (1963) found that the birth weights were much the same as in the control groups. Of more significance was the finding of a corrected prematurity rate of 7% in young primigravidae and of 2% in the controls. Of nine studies included in Table II, a prematurity rate of 10% or greater is demonstrated in five (Aznar and Bennett, 1961 ; Bochner, 1962;Hassan and Falls, 1964;Jarvinen and Katila, 1959;Poliakoff, 1958). This prematurity rate is to some extent reflected in a higher perinatal mortality rate in the younger patients.Increased Frequency of Prolonged Labour.-There is no uniformity of opinion on what constitutes prolonged labour. In the reported studies on young primigravidae the upper limit for labour varies from 24 hours (Poliakoff, 1958 ;Aznar and Bennett, 1961) to 48 hours (Sinclair, 1952). The reported average duration for normal labour varies from 9 hours and 42 minutes to 16 hours and 32 minutes (Clough, 1958 ; Hassan and Falls, 1954 experienced. In the present study the definite tendency to conservatism in view of the high illegitimacy rate probably accounted to a certain extent for the increased incidence of prolonged labour. ConclusionsPregnant adolescents demonstrate an increased tendency to at least two major complications in pregnancy-namely, toxaemia of pregnancy and prematurity-which should be avoided by more adequate antenatal care; these patients should therefore be seen at least weekly after the 32nd week.From the standpoint of pure physical ability the young primigravida does very well-in many respects better than the slightly older patient. A high incidence of spontaneous vaginal delivery can be expected and operative intervention thereby avoided. SummaryA series of 100 consecutive white primigravid patients aged 13 to 16 years was analysed and compared with a control group of 100 consecutive white 22-year-old primigravid patients.In the former there was a high incidence of hypertension and toxaemia. The prematurity rate was higher than in the control group, as was the perinatal mortality. There was also a greater incidence of prolonged labour. Though the foetal head was not engag...

show abstract

Section: Discussionmentioning

confidence: 99%

Renal failure after cholangiography.

Craft¹,

Swales²

1967

BMJ

View full text Add to dashboard Cite

show abstract

“…Despite extensive investigation the precise cause of acute renal failure following OCG remains uncertain. Contrast agent -induced renal failure following ingestion of modern cholecystographic agents is also often but not always dose related [14,[17][18][19]. Setter et al in 1963 [15] and Harrow and Sloane in 1965 [16] collected a total of 14 patients with acute renal failure following ingestion of bunamiodyl (Ora-bilex| an agent eventually withdrawn from the market.…”

Section: Major Reactions To Contrast Mediamentioning

confidence: 99%

“…The etiology of the renal damage caused by cholecystographic media is not clear [12][13][14][15][16][17][18][19][20][21]. Interestingly, most patients have had no underlying renal disease, as opposed to the situation with renal failure following use of the intravenous urographic agents [13,15,16,19].…”

Section: Major Reactions To Contrast Mediamentioning

confidence: 99%

“…Interestingly, most patients have had no underlying renal disease, as opposed to the situation with renal failure following use of the intravenous urographic agents [13,15,16,19]. These include excessive dosage, enhanced gastrointestinal absorption, and decreased hepatic clearance caused by liver derangement [12,13,16,17,21]. These include excessive dosage, enhanced gastrointestinal absorption, and decreased hepatic clearance caused by liver derangement [12,13,16,17,21].…”

Section: Major Reactions To Contrast Mediamentioning

confidence: 99%

“…Certainly factors that promote high blood levels of contrast agent would appear to be important. Other proposed mechanisms include a direct toxic effect on the renal tubules [15,20], crystalluria with intratubular block [15,16], and constriction of the preglomerular vessels with subsequent renal ischemia [13,17]. Other proposed mechanisms include a direct toxic effect on the renal tubules [15,20], crystalluria with intratubular block [15,16], and constriction of the preglomerular vessels with subsequent renal ischemia [13,17].…”

Section: Major Reactions To Contrast Mediamentioning

confidence: 99%

See 2 more Smart Citations