Renal toxicity of heavy metals (cadmium and mercury) and their amelioration with ascorbic acid in rabbits

Ali, Shaukat; Hussain, Sidra; Khan, Rizwan Taj; Mumtaz, Sadaf; Ashraf, Noman; Andleeb, Saiqa; Shakir, Hafiz Abdullah; Tahir, Hafız Muhammad; Khan, Muhammad Aslam; Ulhaq, Mazhar

doi:10.1007/s11356-018-3819-8

Cited by 63 publications

(22 citation statements)

References 43 publications

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“…All animal trials were executed according to local and worldwide procedures. The nearby way is the Wet op de dierproeven (article 9) of Dutch law (international) and an associated rule planned via the Bureau of Animal Research Licensing, Local University as detailed in our earlier papers (Saba et al 2021;Hussain et al 2020;Ara et al 2021;Khan et al 2019;Ali et al 2019;Mumtaz et al 2019;Mughal et al 2019;Dar et al 2019). The rearing and use of animal were carried out using NIH Publication "Guide for the Care and Use of Laboratory Animals" (NRC 2004)…”

Section: Ethical Statementmentioning

confidence: 99%

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Large scale toxicological evaluation of lead acetate in broiler chicken

Ali¹,

Minhas²,

Awan³

et al. 2021

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Among heavy metals, lead is one of the very toxic pollutants of the environment. Its accumulating nature in the body makes it a great threat to public health particularly when humans consume lead intoxicated foods like chickens. The main purpose of the conducted research was to elucidate the bioaccumulation of lead in different organs of chickens and its toxicological effects on various organs and biochemical parameters. An experimental study on the effect of lead acetate toxicity in chicks was conducted by orally administration for consecutive thirty days. Thirty-chicks were categorized into A, B, C, D, E, and F groups with lead acetate dose rate 0, 71, 142, 213, and 284 mg/kg body weight, correspondingly. During the experiment, various biochemical parameters (uric acid, GPT, creatinine, ALP, LDH, ASAT, ALT, glutathione, superoxide dismutase) were measured employing commercially available kits. At the end of experimentation, and lead accumulation in liver, kidney and brain was estimated by absorption spectrophotometer. Some biochemical parameters like uric acid, GPT, creatinine, ALP, LDH, AST, and ALT were increased while the level of glutathione and superoxide dismutase, was found to be decreased after exposure to lead acetate. In present study, the pattern of metal accumulation in different organs directly related with concentration of metal. The order of metal accumulation in organs is; liver > kidney > brain. In the present study, supplementation of lead acetate has affected the exposed chicken. Mostly the blood profile and chemistry are perturbed. These effects might be due to the accumulation of lead in the brain, kidneys, and liver which may result in neurotoxicity, nephrotoxicity, and hepatotoxicity. To refine such outcomes, further studies in the future are recommended.

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Section: Ethical Statementmentioning

confidence: 99%

“…For biochemical analyses, serum samples were kept at -20°C (Hussain et al 2020;Naito, 1984). Various biochemical parameters were analyzed by commercially available respective kits or already designated methods (Suleman et al 2016;Mumtaz et al 2019;Ali et al 2019;Khan et al 2019;Hussain et al 2020)…”

Section: Biochemical Analyses (Blood Biochemistry)mentioning

confidence: 99%

Large scale toxicological evaluation of lead acetate in broiler chicken

Ali¹,

Minhas²,

Awan³

et al. 2021

Preprint

Self Cite

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“…All animal trial techniques were directed as per local and worldwide controls. The nearby direction is the Wet op de dierproeven (Article 9) of Dutch Law (International) as detailed in our previous studies (Ali et al, 2020a;Ali et al, 2020b;Hussain et al, 2020;Ara et al, 2020;Ali et al, 2019;Khan et al, 2019;Mumtaz et al, 2019;Mughal et al, 2019;Dar et al, 2019) and The Institutional Bioethics Committee at Government College University Lahore, Pakistan (No. GCU/IIB/21 dated: 08-01-2019).…”

Section: Ethical Statementmentioning

confidence: 99%

Silk derived formulations for accelerated wound healing in diabetic mice

Tariq¹,

Tahir²,

Butt³

et al. 2021

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Background The present study aimed to prepare effective silk derived formulations in combination with plant extract (Aloe vera gel) to speed up the wound healing process in diabetic mice. Methods Diabetes was induced in albino mice by using alloxan monohydrate. After successful induction of diabetes in mice, excision wounds were created via biopsy puncture (6 mm). Wound healing effect of silk sericin (5%) and silk fibroin (5%) individually and in combination with 5% Aloe vera gel was evaluated by determining the percent wound contraction, healing time and histological analysis. Results The results indicated that the best biocompatible silk combination was of 5% silk fibroin and 5% Aloe vera gel in which wounds were healed in 13 days with wound contraction: 98.33 ± 0.80%. In contrast, the wound of the control group (polyfax) healed in 19 day shaving 98.5 ± 0.67% contraction. Histological analysis revealed that the wounds which were treated with silk formulations exhibited an increased growth of blood vessels, collagen fibers, and much reduced inflammation. Conclusion It can be concluded that a combination of Bombyx mori silk and Aloe vera gel is a natural biomaterial that can be utilized in wound dressings and to prepare more innovative silk based formulations for speedy recovery of chronic wounds.

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“…Of the ninety of the literatures reviewed [13] only three (3.3%) discuss mercury chelating activity [40][41][42]. Twenty-seven (27) plant-derived natural products were found to alleviative effects of mercury, and four of these natural materials need to be recommended for further comprehensive clinical exploitation [13], namely ascorbic acid [43][44][45], α tocopherol [46], beta carotene [47], and the flavonoid quercetin [48]. The flavonoid quercetin is a typical flavonoid, possesses diverse biochemical and physiological actions, including antiplatelet, PLOS ONE estrogenic, and anti-inflammatory properties [49].…”

Section: Plos Onementioning

confidence: 99%

Leaf ethanolic extract of Etlingera hemesphaerica Blume mitigates defects in fetal anatomy and endochondral ossification due to mercuric chloride during the post-implantation period in Mus musculus

et al. 2021

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This study aimed to investigate the effectiveness of leaf ethanolic extract of Etlingera hemisphaerica (LE3H) in reducing defects in fetal anatomy and endochondral ossification in mice induced by HgCl2 during the post-implantation period. Pregnant mice were divided into four groups, each consisting of 10 dams, and received drink and food ad libitum. The first group was administered LE3H (E1), the second one HgCl2 (E2), the third one HgCl2+LE3H (E3), and the fourth was control (E0), administered double-distilled water only. HgCl2 (5 mg/kg bw) was administrated by injection intraperitoneally on gestation day (GD)9 and LE3H (0.39 mg/g bw) was administered by gavage on GD10. The treated and control animals were killed by cervical dislocation on GD18, dissected, and the morphologically normal living fetuses (MNLF) were collected. The MNLF of E0, E1, E2, and E3 from 5 dams were fixed with Bouin solution, and observed using the free hand razor blade technique for soft tissue examination. The remaining MNLF were fixed with 96% ethanol, and then stained with Alizarin Red S and Alcian Blue for ossification examination. Index of length of ossified part (ILOP) of humerus, index of width of ossified part (IWOP) of humerus, ILOP of femur, and IWOP of femur were calculated. E2 had higher cases of anatomical defects (74,6%) than E3 (48.9%), E1 (15.0%), and E0 (0%). E2 had humerus IWOP of 0.82±0.03, which was significantly lower than that of E0 (0.89±0.04) and E1 (0.89±0.03), while that of E1 and E0 was not significantly different from each other. Meanwhile, IWOP in E3 (0.88±0.03) was significantly higher than that in E2, but not different from that in E1 and E0. Thus, LE3H mitigated defects in fetal anatomy and endochondral ossification induced by HgCl2 in mice.

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Renal toxicity of heavy metals (cadmium and mercury) and their amelioration with ascorbic acid in rabbits

Cited by 63 publications

References 43 publications

Large scale toxicological evaluation of lead acetate in broiler chicken

Large scale toxicological evaluation of lead acetate in broiler chicken

Silk derived formulations for accelerated wound healing in diabetic mice

Leaf ethanolic extract of Etlingera hemesphaerica Blume mitigates defects in fetal anatomy and endochondral ossification due to mercuric chloride during the post-implantation period in Mus musculus

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