Renal toxicological evaluations of sulphonated nanocellulose from Khaya sengalensis seed in Wistar rats

Adewuyi, Adewale; Otuechere, Chiagoziem A.; Adebayo, Olusegun L.; Anazodo, Chibuzo; Pereira, Fabiano Vargas

doi:10.1016/j.cbi.2018.02.015

Cited by 34 publications

(16 citation statements)

References 43 publications

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“…The inter-organ differences in response to antioxidant principles were further observed with a significant decrease in liver GPx across all treatment doses as against the significant increase observed in renal GPx activity in rats exposed to 50 mg/kg hydroxamic acid. This observed increase in renal GPx activity agreed with a previous study reporting an elevated GPx activity in the kidney of rats treated with nanocellulose synthesized from Khaya senegalensis seeds [34].…”

Section: Discussionsupporting

confidence: 93%

Green synthesized hydroxamic acid administered in high dose disrupts the antioxidant balance in the hepatic and splenic tissues of albino rats

2020

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Background: Hydroxamic acids are currently being used in diverse biological activities. We investigated the effect of hydroxamic acid, synthesized from Cyperus esculentus seeds, on the antioxidant status of the liver, spleen, and kidney of Wistar rats. Methods: Twenty male rats were randomly divided into three treatment groups using hydroxamic acid at doses of 5, 15, and 50 mg/kg and a control group using distilled water. Rats were sacrificed 24 h after a seven-day repeated oral dosing. After that, the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and the levels of glutathione (GSH) and malondialdehyde (MDA) were investigated in the organs. Results: Our data showed that MDA levels remained unaltered in the liver, spleen, and kidney. However, it was found that hydroxamic acid at the dose of 50 mg/kg significantly increased SOD activity but depleted CAT, GPx activities and GSH levels in the liver when compared to the control groups. In splenic tissue, SOD activity and GSH levels were significantly diminished. Contrarily, in the kidney, treatment of rats with 50 mg/kg hydroxamic acid did not affect SOD activity, but GPx activity was increased while GST activity was decreased when compared to the controls. Conclusion: Overall, hydroxamic acid may enhance antioxidant enzyme activities in the liver and kidney. However, caution is required at higher doses to forestall oxidative stress in the hepatic and splenic tissues.

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Section: Discussionsupporting

confidence: 93%

Green synthesized hydroxamic acid administered in high dose disrupts the antioxidant balance in the hepatic and splenic tissues of albino rats

2020

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“…The peaks between 2800-2950 cm‾¹ indicate the C-H stretching of alkane, while the peaks in the region of 1712cm‾¹ expressed the C=O stretching of ketones. Observed spectra within 1500-1100 range corresponded to the C-O stretch common to flavonoids and terpenes [35,36]. This present study also revealed the inhibitory effect of the ALEO against Bacillus cereus ATCC 10872, Escherichia coli ATCC 25922, and Bacillus subtilis.…”

Section: Biochemical Analysessupporting

confidence: 68%

Essential oil of Alchornea laxiflora (benth): phytochemical, antimicrobial and toxicity evaluations

2019

Lett Appl NanoBioSci

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Alchornea laxiflora belonging to the Euphorbiaceae family has ethnomedicinal applications as antimalarial, anti-inflammatory, and anti-microbial agent. This present study investigated the spectroscopic, antibacterial, and toxicity profile of essential oil of Alchornea laxiflora (ALEO). The composition of ALEO was detected using Gas Chromatography-Mass Spectrometry (GC-MS) and Fourier Transform Infrared (FTIR) Spectroscopy. Using agar disc diffusion, the antibacterial activity of ALEO against five clinical isolates: Bacillus subtilis ATCC 6633, Bacillus cereus ATCC 10872, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 9027, and Staphylococcus aureus ATCC 25923 was evaluated. The toxicity profile of ALEO was obtained in studies involving Wistar rats. GC-MS analysis identified eight bioactive compounds, mostly fatty acids and their ester derivatives. The FTIR spectrum revealed peaks at 3500-3180 cm‾¹ and 2950-2800 cm‾¹ corresponding to O-H stretch band of alcohol and the C-H stretch of aliphatic alkane, respectively. The highest zone of inhibition diameter was recorded against Bacillus cereus ATCC 10872 and Escherichia coli ATCC 25922, while the least zone of inhibition was against Pseudomonas aeruginosa ATCC 9027. Oral administration of ALEO caused an elevation in Alanine aminotransferase activity. The essential oil of Alchornea laxiflora has potential as an antibacterial. However, the doses used in this study might be slightly hepatotoxic

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“…Similarly, Park et al () showed that CNC elicited alterations in immune response following pulmonary exposure to BALB/c mice. The toxicity of sulphonated nanocellulose in renal tissue of rats has also been reported (Adewuyi, Otuechere, Adebayo, Anazodo, & Pereira, ). From the preceding, studies on the toxicity of vermiculite–cellulose nanocrystal hybrid are scanty, and before further incorporation into condiments, cosmetics and water treatment solutions, there is need to evaluate the toxicity of VERN in the male reproductive system.…”

Section: Introductionmentioning

confidence: 67%

Salubrious effects of a vermiculite–cellulose‐based bionanocomposite on oxidative stress indices and histomorphology of male Wistar rats

et al. 2019

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There is a current interest from the food packaging, biomedical and agricultural sectors in hybrid materials formed from clays and natural polymeric compounds. However, research investigating the toxicity of vermiculite–cellulose nanocrystal (VERN) hybrid on the testes of Wistar rats is rare. Twenty rats, divided into control and treatment groups, were orally administered distilled water, 5, 10, and 20 mg/kg bw VERN daily for two consecutive weeks. At the termination of experiments, the testicular organo‐somatic index, superoxide dismutase, catalase, and gamma‐glutamyl transferase activities were not significantly changed by VERN relative to the controls. Contrarily, myeloperoxidase, glutathione peroxidase, and malondialdehyde levels were depleted in the testes of treated rats. Moreso, VERN increased follicle‐stimulating and luteinizing hormones, and decreased testosterone levels at the 20 mg/kg dose. Histology of the testes revealed healthy looking Leydig cells at the doses of 5 and 10 mg/kg VERN. Overall, these results indicate that oral exposure of VERN was not overly deleterious to the redox and structural histoarchitecture in the testes of rats.

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Renal toxicological evaluations of sulphonated nanocellulose from Khaya sengalensis seed in Wistar rats

Cited by 34 publications

References 43 publications

Green synthesized hydroxamic acid administered in high dose disrupts the antioxidant balance in the hepatic and splenic tissues of albino rats

Green synthesized hydroxamic acid administered in high dose disrupts the antioxidant balance in the hepatic and splenic tissues of albino rats

Essential oil of Alchornea laxiflora (benth): phytochemical, antimicrobial and toxicity evaluations

Salubrious effects of a vermiculite–cellulose‐based bionanocomposite on oxidative stress indices and histomorphology of male Wistar rats

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