Renal Transplant Failure Due to Infiltrating Kaposi Sarcoma

Nauman, Awais; Arshad, Adeel; Mujeeb, Imaad; Asim, Muhammad

doi:10.6002/ect.2017.0052

Cited by 4 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our case, findings consistent with Banff IIA rejection were also noted. The two prior parenchymal invasion cases showed scattered foci of minimal tubulitis 12 or a mild lymphocytic interstitial infiltrate, 13 but no evidence of cellular rejection was reported. This raises the possibility that HHV‐8 or sarcoma cells could induce reactive parenchymal changes mimicking cellular rejection.…”

Section: Discussionmentioning

confidence: 98%

“…Kaposi sarcoma directly involving the kidney allograft is extremely rare with only seven previously reported cases 12,13,34‐38 (Table 1). In two of these cases, neoplastic parenchymal invasion contributed directly to allograft dysfunction 12,13 . The donor and recipient histories and presenting signs and symptoms of the seven prior cases were varied, making generalization difficult.…”

Section: Discussionmentioning

confidence: 99%

“…This report describes an unusual case of donor transmitted HHV‐8 leading to KS in the donor allograft manifesting as acute kidney injury (AKI) from a diffusely infiltrating sarcoma. To our knowledge, there are only two prior case reports of KS presenting as AKI secondary to diffuse sarcomatous infiltration within the kidney allograft 12,13 . Furthermore, this HHV‐8 transmission occurred from a hepatitis C (HCV) viremic donor to a recipient without active HCV viremia.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Infiltrating Kaposi sarcoma presenting as acute kidney injury: An unexpected consequence of deliberate hepatitis C–positive organ transplantation

Story

Sanders

Bashir

et al. 2020

Transplant Infectious Dis

View full text Add to dashboard Cite

Kaposi sarcoma (KS) following kidney transplantation can result from recipient reactivation of latent human herpesvirus 8 (HHV‐8) infection or activation of donor‐acquired HHV‐8 infection. Post‐transplant KS typically manifests with cutaneous pathology, but rare cases of renal allograft involvement have been reported. We describe two cases of donor‐derived HHV‐8 infection in two hepatitis C (HCV) viremia‐negative transplant recipients who each received a kidney from a donor with HCV viremia. One recipient did not develop KS while the other presented with acute kidney injury caused by extensive KS infiltration of the renal parenchyma and metastatic disease. This report reviews the literature for cases of KS involving the renal allograft and highlights an unexpected consequence of deliberate HCV‐positive organ transplantation.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Infiltrating Kaposi sarcoma presenting as acute kidney injury: An unexpected consequence of deliberate hepatitis C–positive organ transplantation

Story

Sanders

Bashir

et al. 2020

Transplant Infectious Dis

View full text Add to dashboard Cite

show abstract

“…Adicionalmente, puede haber acumulación de hemosiderina e infiltrado inflamatorio. Las técnicas de inmunohistoquímica/inmunoperoxidasa también pueden contribuir al diagnóstico, con anticuerpos específicos que detecten la presencia de marcadores como CD31 (figura 6) o que detecten proteínas virales (figuras 3 y 7); estas técnicas también ayudaron a confirmar el diagnóstico en los casos presentados [8,9,34].…”

Section: Discussionunclassified

Sarcoma de Kaposi ganglionar postrasplante renal: reporte de dos casos en un centro de trasplante colombiano

Palacios-Ramírez

Varela-Aguirre

2021

Med. Lab.

View full text Add to dashboard Cite

El cáncer es una causa importante de morbilidad y mortalidad en los receptores de trasplante. La combinación de infecciones virales, terapia de inmunosupresión y la alteración en el sistema inmune en los pacientes trasplantados, contribuyen al desarrollo de cáncer. El sarcoma de Kaposi es causado por el virus herpes humano 8 (VHH-8), y aunque es raro en la población general, puede ser hasta 300 veces más frecuente en los pacientes con trasplante renal. El diagnóstico de la enfermedad se realiza a menudo con base en las características de las lesiones, pero debe ser confirmado por histología. En años recientes, los inhibidores de mTOR han mostrado ser efectivos para el control del sarcoma de Kaposi en los pacientes trasplantados, ya que se interrumpe el efecto antiapoptótico y la angiogénesis dependientes de la proteína mTOR, los cuales son esenciales para el desarrollo y la propagación de células malignas. Se presentan dos casos de pacientes con sarcoma de Kaposi ganglionar, sin lesiones en piel, en nuestro centro de trasplante, quienes respondieron de manera positiva al cambio del esquema inmunosupresor con inhibidores de mTOR.

show abstract

HHV‐8‐associated diseases in transplantation: A case report and narrative review focused on diagnosis and prevention

Kates,

McDade,

Tinney

et al. 2024

Transplant Infectious Dis

View full text Add to dashboard Cite

BackgroundHuman herpes virus 8 (HHV‐8) or Kaposi sarcoma herpesvirus (KSHV) is an opportunistic oncovirus that causes multiple pathologic entities.MethodsWe present a case of fatal HHV‐8‐associated multisystem illness with disseminated Kaposi sarcoma and HHV8‐associated lymphoproliferative disorder with systemic inflammation. We conducted a narrative review of the literature on HHV‐8 in transplantation with a goal of illuminating the spectrum of HHV‐8‐associated diseases in this vulnerable population, modes of disease transmission, and the potential role for donor and recipient screening.ResultsHHV‐8‐associated KS, primary effusion lymphoma (PEL), multicentric Castleman disease (MCD), and KSHV inflammatory cytokine disorder (KICS) may affect transplant recipients; with the exception of KS, these conditions are rare but carry high morbidity and mortality.ConclusionHHV‐8‐associated diseases have diverse and protean manifestations in transplant recipients, with potentially fatal outcomes. HHV‐8 seroprevalence among organ donors and the magnitude of risk for donor‐derived HHV‐8 infection or clinically significant disease remain unknown and require further study. image

show abstract

Renal Transplant Failure Due to Infiltrating Kaposi Sarcoma

Cited by 4 publications

References 9 publications

Infiltrating Kaposi sarcoma presenting as acute kidney injury: An unexpected consequence of deliberate hepatitis C–positive organ transplantation

Infiltrating Kaposi sarcoma presenting as acute kidney injury: An unexpected consequence of deliberate hepatitis C–positive organ transplantation

Sarcoma de Kaposi ganglionar postrasplante renal: reporte de dos casos en un centro de trasplante colombiano

HHV‐8‐associated diseases in transplantation: A case report and narrative review focused on diagnosis and prevention

Contact Info

Product

Resources

About