Renal Transplantation in Patients With Lupus Nephritis: A Single-Center Experience

Ghafari, A.; Etemadi, Jalal; Ardalan, Mohammadreza

doi:10.1016/j.transproceed.2007.12.013

Cited by 29 publications

(19 citation statements)

References 7 publications

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“…This compares to estimates of graft survival in aSLE at 88% at one year, and 67% at five years. In both aSLE and pediatric SLE kidney graft survival is similar to that with other adult or pediatric diseases139, 141–142.…”

Section: Therapymentioning

confidence: 63%

Pediatric Lupus—Are There Differences in Presentation, Genetics, Response to Therapy, and Damage Accrual Compared with Adult Lupus?

Mina

Brunner

2010

Rheumatic Disease Clinics of North America

245

168

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Summary Some complement deficiencies predispose to SLE early in life. Currently, there are no known unique physiological or genetic pathways that can explain the variability in disease phenotypes, as is suggested by studies directly and indirectly comparing cohorts of children and adults with SLE. Children present with more acute illness and have more frequent renal, hematologic and central nervous system involvement at the time of diagnosis compared to adults with SLE. Almost all children require corticosteroids during the course of their disease, and many are treated with immunosuppressive drugs. Despite of a general lack of co-morbid conditions, mortality rates remain higher with pediatric SLE compared to aSLE. Children and adolescents accrue more damage as measured by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index, especially in the renal, ocular and musculoskeletal organ systems. Conversely, cardiovascular mortality is more prevalent in adults with SLE.

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Section: Therapymentioning

confidence: 63%

Pediatric Lupus—Are There Differences in Presentation, Genetics, Response to Therapy, and Damage Accrual Compared with Adult Lupus?

Mina

Brunner

2010

Rheumatic Disease Clinics of North America

245

168

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“…Thrombotic events have been reported more frequently in renal transplantation recipients with aPL worsening their functional prognosis [14, 23]. In a recent study, the presence of LA at the time of renal transplantation was associated with a high rate of allograft nephropathy associated with antiphospholipid syndrome and poor transplantation outcomes [44].…”

Section: Discussionmentioning

confidence: 99%

Renal Transplantation in Systemic Lupus Erythematosus: Outcome and Prognostic Factors in 50 Cases from a Single Centre

Cairoli

Sánchez-Marcos

Espinosa

et al. 2014

BioMed Research International

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Background. End-stage renal disease (ESRD) is an important cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Objectives. To analyze the outcome and prognostic factors of renal transplantation in patients with ESRD due to SLE from January 1986 to December 2013 in a single center. Results. Fifty renal transplantations were performed in 40 SLE patients (32 female (80%), mean age at transplantation 36 ± 10.4 years). The most frequent lupus nephropathy was type IV (72.2%). Graft failure occurred in a total of 15 (30%) transplantations and the causes of graft failure were chronic allograft nephropathy (n = 12), acute rejection (n = 2), and chronic humoral rejection (1). The death-censored graft survival rates were 93.9% at 1 year, 81.5% at 5 years, and 67.6% at the end of study. The presence of deceased donor allograft (P = 0.007) and positive anti-HCV antibodies (P = 0.001) negatively influence the survival of the renal transplant. The patient survival rate was 91.4% at the end of the study. Recurrence of lupus nephritis in renal allograft was observed in one patient. Conclusion. Renal transplantation is a good alternative for renal replacement therapy in patients with SLE. In our cohort, the presence of anti-HCV antibodies and the type of donor source were related to the development of graft failure.

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“…Some showed no difference in outcomes between SLE and non-SLE recipients [201,202], whereas others showed worse allograft but not patient survival in the SLE group [203]. Some showed no difference in outcomes between SLE and non-SLE recipients [201,202], whereas others showed worse allograft but not patient survival in the SLE group [203].…”

Section: Transplantationmentioning

confidence: 99%

Kidney

Rovin¹,

Stillman²

2011

Systemic Lupus Erythematosus

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Renal Transplantation in Patients With Lupus Nephritis: A Single-Center Experience

Cited by 29 publications

References 7 publications

Pediatric Lupus—Are There Differences in Presentation, Genetics, Response to Therapy, and Damage Accrual Compared with Adult Lupus?

Pediatric Lupus—Are There Differences in Presentation, Genetics, Response to Therapy, and Damage Accrual Compared with Adult Lupus?

Renal Transplantation in Systemic Lupus Erythematosus: Outcome and Prognostic Factors in 50 Cases from a Single Centre

Kidney

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