Renal Transport of Sodium During Early Development

Feld, Leonard G.; Corey, Howard E.

doi:10.1016/b978-0-7216-9654-6.50133-8

Cited by 4 publications

(7 citation statements)

References 99 publications

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“…Rothberg and Andronikou [12] first reported a transient Na elevation in preterm neonates treated with tobramycin and Giacoia and Schentag [11] observed that preterm neonates had a higher FENa after continuous gentamicin infusion compared with multiple-dose therapy. Preterm and full-term infants have defective renal Na handling, especially in the first days of life [7,13]. The administration of gentamicin appears to exacerbate this functional defect in early postnatal life.…”

Section: Discussionmentioning

confidence: 95%

“…A sustained rise in Na, Mg, and Ca, but not in K and P, was detected immediately after gentamicin infusion, with the post-infusion excretion values doubling in most cases. A GA of 34 weeks was used as a rough criterion of renal maturity because at this GA nephronogenesis is complete and a more-accelerated renal glomerular and tubular functional maturation is achieved postnatally [6,7]. It was demonstrated that electrolyte wasting after gentamicin infusion takes place irrespective of the renal maturational pattern.…”

Section: Discussionmentioning

confidence: 99%

“…Despite these limitations, the results of the present study may be of clinical importance, especially for tiny sick preterm infants receiving treatment with gentamicin. These babies are usually salt-losers and are at risk of developing a negative Na balance [7]. They are also more susceptible to early onset hypocalcemia [14].…”

Section: Discussionmentioning

confidence: 99%

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Acute effects of gentamicin on urinary electrolyte excretion in neonates

Giapros

Cholevas

Andronikou

2004

Pediatric Nephrology

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It has recently been shown that a single dose of gentamicin causes immediate and transient calcium and magnesium renal wasting in adults. The aim of this study was to determine the acute effect of gentamicin administration on renal electrolyte handling in preterm and full-term neonates. Twenty-three neonates treated with gentamicin for suspected infection were enrolled in the study. Serum and 3-h urine electrolytes were measured before and immediately after gentamicin infusion on the 1st, 3rd, 4th, and 7th day of treatment. Serum gentamicin levels were monitored. Gentamicin caused a statistically significant post-infusion increase in fractional excretion of sodium and magnesium and in the urine calcium to urine creatinine ratio. Potassium and phosphate fractional excretion remained unchanged. The disturbances in electrolyte excretion were observed in full-term as well as in preterm neonates. Serum electrolyte levels remained unchanged. In conclusion, therapeutic doses of gentamicin result in urinary loss of sodium, calcium, and magnesium in neonates immediately after the infusion of the drug. These electrolyte changes may be of clinical importance, especially for sick preterm neonates.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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Acute effects of gentamicin on urinary electrolyte excretion in neonates

Giapros

Cholevas

Andronikou

2004

Pediatric Nephrology

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Section: Discussionmentioning

confidence: 99%

“…Many investigators have shown that the proximal as well as the distal tubular reabsorption of sodium is inversely related to GA [22,23]. In preterm neonates, there is an increased delivery of sodium to the distal tubule due to a defective sodium reabsorption in the proximal tubule, which is known to be associated with prematurity of GA <34 weeks [22,23]. The distal sodium reabsorption is significantly lower in premature infants of 34 weeks GA than in fullterm neonates, suggesting an inability of the distal tubule of the premature infant to handle the increased sodium load [22,23].…”

Section: Discussionmentioning

confidence: 99%

Renal function and effect of aminoglycoside therapy during the first ten days of life

Giapros

Andronikou

Cholevas

et al. 2003

Pediatric Nephrology

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The effect of aminoglycoside administration on kidney functional maturation was evaluated in groups of 30 preterm and 30 fullterm infants who were treated for 7 days because of suspected infection. One of three different aminoglycosides was administered to each subgroup of ten preterm and ten fullterm infants. Changes in tubular function in groups of ten preterm and ten fullterm infants who were not given antibiotics were also compared. The mean gestational age for preterm infants from 32.5 to 33.6 weeks and for fullterm infants between 39.2 and 39.5 weeks. The renal tubular function was assessed by examining the fractional excretion of sodium (FENa), potassium (FEK), phosphorus (FEP), magnesium (FEMg) and uric acid (FEUA) as well as by the urinary excretion of calcium as the calcium/creatinine (UCa/UCr) ratio. Gentamicin affected the normal plasma creatinine (PCr) decline in both treated groups (fullterm and preterm). Disturbances in FENa and UCa/UCr were more pronounced in treated preterm than in fullterm infants especially after netilmicin and gentamicin administration. FEMg was significantly affected in preterm infants treated with gentamicin. The findings of this study indicate that the effect of aminoglycosides on tubular function is dependent upon kidney maturity and the type of the aminoglycoside used for therapy.

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Adjustable fortification of human milk fed to preterm infants

Cooke

2006

J Perinatol

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Renal Transport of Sodium During Early Development

Cited by 4 publications

References 99 publications

Acute effects of gentamicin on urinary electrolyte excretion in neonates

Acute effects of gentamicin on urinary electrolyte excretion in neonates

Renal function and effect of aminoglycoside therapy during the first ten days of life

Adjustable fortification of human milk fed to preterm infants

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