Renal tuberculosis presenting as acute pyelonephritis – A rarity

Verma, Ajay Kumar; Mishra, Ashwini Kumar; Kumar, Manoj; Kant, Surya; Singh, Anubhuti; Singh, Ajay

doi:10.1016/j.ijtb.2015.07.010

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…In spite of the fact that the World Health Organisation recognised TB as a global problem, urogenital TB (UGTB) did not receive the attention of the World Health Organisation, even though UGTB is the second most common form of TB in the regions with a severe epidemic situation. The proportion of UGTB varies in different countries and constitutes 30–41% (Jablonskij, Mushkin, Belilovskij, & Galkin, ; Maciá Escalante et al, ; Verma, Mishra, Kumar, & Kant, ). The clinical manifestation of UGTB is flexible and mimics numerous other diseases, leading to delayed diagnosis and inefficient therapy.…”

Section: Introductionmentioning

confidence: 99%

Application of the allogenic mesenchymal stem cells in the therapy of the bladder tuberculosis

Yudintceva

Bogolyubova

Muraviov

et al. 2017

J Tissue Eng Regen Med

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Urogenital tuberculosis (TB) often leads to contraction of the bladder, a reduction of the urinary reservoir capacity, and, in the latest stage, to real microcystitis up to full obliteration. Bladder TB Stage 4 is unsuitable for conservative therapy, and cystectomy with subsequent enteroplasty is indicated. In this study, using a model of bladder TB in New Zealand rabbits, the therapeutic efficacy of the interstitial injection of autologous bone-derived mesenchymal stem cells (MSCs) combined with standard anti-TB treatment in the restoration of the bladder function was demonstrated. For analysis of the MSC distribution in tissues, the latter were labelled with superparamagnetic iron oxide nanoparticles. In vitro studies demonstrated the high intracellular incorporation of nanoparticles and the absence of cytotoxicity on MSC viability and proliferation. A single-dose administration of MSCs into the bladder mucosal layer significantly reduced the wall deformation and inflammation and hindered the development of fibrosis, which was proven by the subsequent histological assay. Confocal microscopy studies of the bladder cryosections confirmed the presence of superparamagnetic iron oxide nanoparticle-labelled MSCs in different bladder layers of the treated animals, thus indicating the role of stem cells in bladder regeneration.

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Section: Introductionmentioning

confidence: 99%

Application of the allogenic mesenchymal stem cells in the therapy of the bladder tuberculosis

Yudintceva

Bogolyubova

Muraviov

et al. 2017

J Tissue Eng Regen Med

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“…16,33,37 Treatment of renal TB includes use of anti-TB therapy for a prolonged period, nephrectomy for non-functioning kidneys and renal masses and nephrostomy or stent placement for ureteric strictures to relieve obstruction. 2,9,11,12,16,19,27 Fine needle aspiration (FNA) should be considered before performing nephrectomy in patients from an endemic area presenting with an atypical renal mass. 9,12,18,27,29 This is an important consideration in young patients as renal tissue can be preserved if the diagnosis of TB is made preoperatively.…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of renal TB poses a challenge because of the non-specific presentation as well as the intermittent and low yield of the mycobacteria in the urine resulting in a low sensitivity of urine tests. Three early-morning urine specimens for Acid- Fast Bacilli (AFB) culture and histology is the gold standard for the diagnosis; 8,13,16,19 however, urine culture demonstrates a low sensitivity of 30% – 40%. 15 Some authors suggest more specimen collection, up to 5 and even up to 10 specimens.…”

Section: Introductionmentioning

confidence: 99%

Multidetector computed tomography has replaced conventional intravenous excretory urography in imaging of the kidneys: A scoping review of multidetector computed tomography findings in renal tuberculosis

Mthalane

Dlamini

2018

S. Afr. j. radiol.

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Background: Tuberculosis (TB) is a worldwide infectious disease burden, especially in non-developed countries, with increased morbidity and mortality among human immunodeficiency virus (HIV)-infected patients. Extrapulmonary TB is rare and renal TB is one of the commonest manifestations. The end result of renal TB is end-stage renal disease; however, this can be avoided if the diagnosis is made early. The diagnosis of renal TB is challenging because of the non-specific presentation and low sensitivity of clinical tests. Although the sequel of TB infection in the kidney causes varying manifestations depending on the stage of the disease, multidetector computed tomography (MDCT) is capable of demonstrating early findings. We performed a 20-year scoping review of MDCT findings in renal TB to promote awareness.Aim: To identify specific MDCT imaging characteristics of renal TB, promote early diagnosis and increase awareness of the typical imaging features.Methods and material: We searched published and unpublished literature from 1997 to 2017 using a combination of search terms on electronic databases. We followed the Joanna Briggs Institute guidelines.Results: A total of 150 articles were identified, of which 145 were found through electronic search engines and 5 were obtained from grey literature. Seventy-nine articles that fulfilled our inclusion criteria were reviewed. These included original research, case reports, literature review, organisational reports and grey literature.Conclusion: Multidetector computed tomography can reproduce images comparable with intravenous excretory urography; together with advantages of being able to better assess the renal parenchyma and surrounding spaces, it is important in suggesting the diagnosis of renal TB and clinicians should consider including MDCT when investigating patients with recurrent urinary tract infection not responding to usual antimicrobial therapy.

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“…Genitourinary tuberculosis (GUTB) is the second most common extra-pulmonary TB, with kidney being the most frequent site of infection. 6 We report a case of Emphysematous pyelonephritis (EPN) with uncontrolled diabetes mellitus later diagnosed as a case of renal tuberculosis.…”

Section: Introductionmentioning

confidence: 99%

Renal Tuberculosis Presented as Emphysematous Pyelonephritis: A Case Report

Mahmood¹,

Hassan²,

Siddiqui³

et al. 2020

Anwer Khan Mod Med Coll J

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Emphysematous pyelonephritis(EPN) is an acute necrotic infection of the kidney which is characterized by presence gas in the renal parenchyma. Uncontrolled diabetes mellitus and obstruction of the urinary tract are the main predisposing factors and Mycobacterium tuberculosis is a rare causative pathogen. One of the major health problem faced particularly by the developing world since ages is that of tuberculosis (TB). Genitourinary tuberculosis (GUTB) is the second most common extra-pulmonary TB, with kidney being the most frequent site of infection. We herein report a case of a patient with uncontrolled diabetes mellitus who was admitted through emergency department with symptoms of pyelonephritis. Imaging revealed the gas in the renal parenchyma establishing the diagnosis and as we found sterile pyurea we searched for Mycobacterium tuberculosis. GUTB was diagnosed and was treated successfully with anti TB drugs. EPN is a medical emergency and once diagnosed, attention must be paid to avoid high mortality rates. Anwer Khan Modern Medical College Journal Vol. 11, No. 1: Jan 2020, P 73-77

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Renal tuberculosis presenting as acute pyelonephritis – A rarity

Cited by 5 publications

References 9 publications

Application of the allogenic mesenchymal stem cells in the therapy of the bladder tuberculosis

Application of the allogenic mesenchymal stem cells in the therapy of the bladder tuberculosis

Multidetector computed tomography has replaced conventional intravenous excretory urography in imaging of the kidneys: A scoping review of multidetector computed tomography findings in renal tuberculosis

Renal Tuberculosis Presented as Emphysematous Pyelonephritis: A Case Report

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