Renal tubular acidosis does not alter circulating values of calcitriol

Chesney, Russell W.; Kaplan, Bernard S.; Phelps, Mary; DeLuca, Hector F.

doi:10.1016/s0022-3476(84)80588-0

Cited by 35 publications

(6 citation statements)

References 16 publications

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“…In contrast, with half dose NH 4 Cl, the drop in serum total CO 2 was milder, and the serum 1,25 dihydroxyvitamin D was not much different from control. This latter observation, fits in well with Chesney et al's [14] earlier observation of mild acidosis. The strength of Krapf et al's innovative study [16] is to focus attention on how significant acidosis affects phosphate and parathyroid hormone activities, which were inadequately examined in previous studies on the interactions between acidosis and calcium/vitamin D metabolism.…”

Section: Hypercalciuria Calcium and Vitamin Dsupporting

confidence: 92%

“…This observation was confirmed by subsequent studies. However, in children with renal tubular acidosis, Chesney et al [14] showed no suppression of serum 1,25 dihydroxyvitamin D. However, the degree of acidosis was rather mild in this cohort of children. Finally, Weber et al [15] showed no suppression of 25 hydroxyvitamin D in volunteers made severely acidotic with NH 4 Cl.…”

Section: Hypercalciuria Calcium and Vitamin Dcontrasting

confidence: 51%

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The role of metabolic acidosis in chronic kidney diseases

Chan

2010

Asian Biomedicine

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Background and objectives:This review focuses on three areas, basic acid-base physiology especially concerning hydrogen ion balance, development of acidosis in chronic kidney disease (CKD), and the consequences of acidosis. We highlight what is well established, what is less certain, and what is unknown. Method and results:The literature on acidosis in CKD were searched from 2004 to 2010 utilizing PubMed, Google Scholar, and Ovid to augment the classic work on acid base physiology over the past three decades. The original research in endogenous acid production and net acid excretion were reviewed. Touching upon the development of metabolic acidosis in CKD, we focused on the consequences of chronic metabolic acidosis on growth and other important variables. Finally, we recognize the significant issue of patients' medical non-compliance and presented treatment strategy to counter this problem. Conclusion:The correction of acidosis in chronic kidney disease needs no advocacy. The case is made conclusively. Patient non-compliance because of the medication that needs to be taken several times a day is a problem, requiring due diligence.

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Section: Hypercalciuria Calcium and Vitamin Dsupporting

confidence: 92%

Section: Hypercalciuria Calcium and Vitamin Dcontrasting

confidence: 51%

The role of metabolic acidosis in chronic kidney diseases

Chan

2010

Asian Biomedicine

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“…We have been unable to find another study of vita min D metabolites in dRTA except for the 1984 report by Chesney et al [31], who found normal serum levels of 25(OH)D and 1,25(OH) 2 D in 7 children with dRTA, findings similar to those on our 2 adult patients before alkali therapy started. Only 2 of Chesney’s patients had evidence of bone disease, and vitamin D metabolites were not measured while bone disease was recovering during alkali treatment, so the findings of these authors do not disagree with our own.…”

Section: Discussionsupporting

confidence: 56%

Distal Renal Tubular Acidosis: Alkali Heals Osteomalacia and Increases Net Production of 1,25-Dihydroxyvitamin D

Wrong

Henderson²,

Kaye³

2005

Nephron Physiol

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“…If we consider the normal eGFR levels in our patients and the normal PTH status with idRTA in two studies of adults [9,26], the possibility of significant secondary hyperparathyroidism in our idRTA patients appears less likely. Chesney et al reported no alteration in circulating calcitriol levels with renal tubular acidosis [27], whereas Krapf et al described stimulated calcitriol production with chronic metabolic acidosis [28]. In the absence of values for vitamin D levels, we cannot comment on this issue; however, if we consider mild acidosis in the patients with idRTA, altered vitamin D levels should not have significantly affected the height SDS in these patients.…”

Section: Discussionmentioning

confidence: 86%

Bicarbonate therapy improves growth in children with incomplete distal renal tubular acidosis

et al. 2009

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Incomplete distal renal tubular acidosis (idRTA) has recently been associated with osteoporosis and growth retardation, attributed to the mild persistent metabolic acidosis. We hypothesized a therapeutic benefit from bicarbonate therapy on growth parameters in children with idRTA. In a study group of 40 surgically treated patients with posterior urethral valve (PUV) and normal estimated glomerular filtration rate, we evaluated the change in height standard deviation scores (SDSs) while they were on bicarbonate therapy in the presence of idRTA and complete distal renal tubular acidosis (dRTA). Age- and gender-matched healthy subjects constituted the control group (n = 55). Incomplete dRTA was evaluated by ammonium chloride acidification. The baseline height SDS of -1.94 +/- 0.41 and -5.31 +/- 1.95 in the groups with idRTA and complete dRTA, respectively, were significantly lower than that of the controls. After a follow-up period of 24.7 +/- 8.3 months on sodium bicarbonate therapy, the idRTA patients had a 66% increase in height SDS compared with 26% and 3% increases in the patients with PUV with complete dRTA and without dRTA, respectively. At the end of follow-up, mean height SDS in the group with idRTA no longer remained significantly lower than that of the controls (P = 0.42). We concluded that bicarbonate therapy improves height SDS in idRTA. This issue needs further validation in larger studies.

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Renal tubular acidosis does not alter circulating values of calcitriol

Cited by 35 publications

References 16 publications

The role of metabolic acidosis in chronic kidney diseases

The role of metabolic acidosis in chronic kidney diseases

Distal Renal Tubular Acidosis: Alkali Heals Osteomalacia and Increases Net Production of 1,25-Dihydroxyvitamin D

Bicarbonate therapy improves growth in children with incomplete distal renal tubular acidosis

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