Renal Tubular Acidosis

Pohlman, T.; Hruska, Keith A.; Menon, Mani

doi:10.1016/s0022-5347(17)49682-0

Cited by 16 publications

(5 citation statements)

References 7 publications

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“…These observations make renal acidification defects an important factor in the pathogenesis of renal calculi in MSK. This has considerable therapeutic implications, since prophylactic intervention in patients with RTA is available (Backman et al, 1980;Pohlman et al, 1984). We use sodium bicarbonate tablets, 1 to 3 meq/kg, which through correction of the acidosis (constant or intermittent) neutralises the suspected lithogenic factors.…”

Section: Discussionsupporting

confidence: 52%

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Renal Acidification Defects in Medullary Sponge Kidney

Osther

Hansen

Røhl

1988

British Journal of Urology

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Thirteen patients with medullary sponge kidney underwent a short ammonium chloride loading test to investigate their renal acidification capacity. All but 1 presented with a history of recurrent renal calculi and showed bilateral widespread renal medullary calcification on X-ray examination. Nine patients had some form of renal acidification defect; 8 had the distal type of renal tubular acidosis, 2 the complete and 6 the incomplete form. One patient had proximal renal tubular acidosis. These findings, which suggest that renal acidification defects play an important role in the pathogenesis of renal calculi in medullary sponge kidney, have considerable therapeutic implications.

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Section: Discussionsupporting

confidence: 52%

“…Progression from incomplete to complete forms of RTA has been documented (Backman et al, 1980;Pohlman et al, 1984). In this study 2 patients (15%) with complete distal RTA were found.…”

Section: Discussionmentioning

confidence: 99%

Renal Acidification Defects in Medullary Sponge Kidney

Osther

Hansen

Røhl

1988

British Journal of Urology

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“…Var ious numerical values have been proposed as the mini mum urinary pH [14,15]. Following Pohlman et al [9], we postulated that RTA-1 was present if the urinary pH never fell below 5.4 when presented with an acid load. The galenic form of ammonium chloride was a crushed tablet so that it would be absorbed easily [8], Using this criterion, we identified 11 cases of RTA-1.…”

Section: Resultsmentioning

confidence: 89%

“…Japan) every' hour, and the serum pH or bicarbonate was measured at 2 and 4 h . If the serum pH decreased to < 7 .3 2 or the scrum bicarbonate was < 16 mEq/liter but the urinary pH remained > 5.4. the diagnosis of RTA was con firmed [9], RTA-1 was designated as the complete form if acidosis was confirmed by blood gas analysis and as the incomplete form if it was not.…”

Section: Methodsmentioning

confidence: 99%

Incidence and Clinical Features of Renal Tubular Acidosis-1 in Urolithiasis

Itô¹,

Kotake²,

Suzuki³

1993

Urol Int

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To elucidate the frequency and clinical picture of renal tubular acidosis-1 (RTA-1) in nephrolithiasis, the acid-loading test was performed in 474 patients with calcium-containing stones. RTA-1 was detected in a total of 11 patients (6 men and 5 women, 2.3%). The incidence of RTA-1 in female patients tended to be higher than in male patients (3.2 vs. 1.9%). One male patient had the complete form, the others had incomplete form. There was a tendency that RTA-1 patients were younger than non-RTA-1 patients in men, and the former were older than the latter in women. The percentages of positive family history and positive past history were 27 and 45 %, respectively. Stones were single in 7 cases and multiple in 4 cases. They were unilateral in 10 cases, and bilateral in 1 case. Hypercalciuria was detected in 2 of the 11 cases, hyperuricosuria was present in none of the 11 cases, and hyperoxaluria in 2 of 8 cases examined. Stones were composed of calcium oxalate in 2 cases, calcium phosphate in 2, and calcium oxalate mixed with calcium phosphate in 3.

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“…If the pH is found to be less than 5 5 then renal tubular acidosis can be excluded. 24 The laboratory should test the sample, with a dipstick, for the presence of ketones. Any ketotic sample should be discarded because ketones interfere with the analysis of creatinine.…”

Section: Idiopathic Stonesmentioning

confidence: 99%

Renal stone disease--investigative aspects.

Henderson¹

1993

Archives of Disease in Childhood

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Renal Tubular Acidosis

Cited by 16 publications

References 7 publications

Renal Acidification Defects in Medullary Sponge Kidney

Renal Acidification Defects in Medullary Sponge Kidney

Incidence and Clinical Features of Renal Tubular Acidosis-1 in Urolithiasis

Renal stone disease--investigative aspects.

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