Renal tumors in the second decade of life: results from the California Cancer Registry

Grabowski, Julia; Silberstein, Jonathan L.; Saltzstein, Sidney L.; Saenz, Nicholas C.

doi:10.1016/j.jpedsurg.2009.02.019

Cited by 13 publications

(15 citation statements)

References 26 publications

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“…Despite this dramatically reduced incidence, both our study and that of Pastore and colleagues [12] found that Wilms tumor remained the most common renal tumor, even in children older than 10 years of age (75% and 65%, respectively). Among the non-Wilms tumors, renal cell carcinoma is the predominant tumor type, making up 15% of all renal tumors and 51% in another series that included patients aged 10-20 years [10]. This is consistent with the younger median age at diagnosis of the Wilms tumor (11 years) compared with non-Wilms tumors (14 years).…”

Section: Discussionsupporting

confidence: 68%

“…Some of these tumors show specific age distributions, such as mesoblastic nephroma, in which .90% of cases occur in the 1st year of life and virtually all rhabdoid tumors are diagnosed in the 1st 5 years of life [2][3][4][5][6]. Conversely, renal cell carcinoma, primitive neuroectodermal tumor, and anaplastic Wilms tumor are more common in older children [7][8][9][10]. The aim of this study was to describe the clinicopathologic features and outcome of primary renal tumors in children aged 10-16 years registered in 2 consecutive clinical trials in the United Kingdom.…”

Section: Introductionmentioning

confidence: 99%

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Renal Tumors in Children Aged 10–16 Years: A Report from the United Kingdom Children's Cancer and Leukaemia Group

et al. 2011

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Wilms tumor is the most common renal tumor of childhood. However, other epithelial, mesenchymal, and neuroectodermal neoplasms may also arise in the kidney during childhood, several of which show specific age distributions; in the 1st year of life, mesoblastic nephroma and rhabdoid tumor are more common, whereas renal cell carcinoma, primitive neuroectodermal tumor, and anaplastic Wilms tumors are relatively more frequent in older children and adolescents. The aim of this study is to describe the spectrum of renal tumors in children aged 10-16 years using data from 1492 patients registered in the UK Wilms Tumour 3 Trial (1991-2001) and International Society of Paediatric Oncology Wilms Tumour Trial 2001 (2002-2008) clinical trials of renal tumors in childhood. There were 67 (4.6%) tumors in children aged 10-16 years: 50 Wilms tumors (74.6%), 10 (14.9%) renal cell carcinomas, 3 (4.5%) renal medullary carcinomas, 2 (3%) primitive neuroectodermal tumors, 1 clear cell sarcoma of kidney, and 1 desmoplastic small round cell tumor. Fourteen percent of the Wilms tumors in this age group had diffuse anaplasia. Among the 10 renal cell carcinomas, 4 were associated with t(Xp-11.2), 3 were of papillary type II, 1 was papillary type I, 1 was clear cell type, and 1 was unclassified. Five-year overall survival for Wilms tumor was 63% (43% for anaplastic tumors), significantly lower than reported overall survival for all pediatric Wilms tumors. Only 40% of patients with renal cell carcinoma survived, and all patients with other tumors died.

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Section: Discussionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Renal Tumors in Children Aged 10–16 Years: A Report from the United Kingdom Children's Cancer and Leukaemia Group

et al. 2011

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“…34,35 There are few studies about the epidemiology of pediatric renal carcinomas because of their rarity, making our finding of increased renal carcinoma rates among boys and those aged 15 to 19 years a novel finding. 6,34,36 Renal cancers are known to be increasing among both male and female adults.…”

Section: Discussionmentioning

confidence: 91%

Cancer Incidence Rates and Trends Among Children and Adolescents in the United States, 2001–2009

King²,

et al. 2014

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OBJECTIVES Cancer continues to be the leading disease-related cause of death among children and adolescents in the United States. More current information is needed to describe recent cancer trends and identify demographic and geographic variations. METHODS We analyzed data from the National Program of Cancer Registries and Surveillance, Epidemiology, and End Results statewide registries representing 94.2% of the US population to identify cancers diagnosed among persons aged 0 to 19 years during 2001–2009. Age-adjusted rates and annual percentage change for trends were calculated. Data were stratified by age, gender, race, ethnicity, and geography. RESULTS We identified 120 137 childhood and adolescent cancer cases during 2001–2009 with an age-adjusted incidence rate of 171.01 per million. The overall rate of all cancers combined remained stable over time (annual percent change [APC], 0.3%; 95% confidence interval [CI], −0.1 to 0.7). There was an increase in the overall cancer trend among African American children and adolescents (APC, 1.3%; 95% CI, 0.2 to 2.5). An increasing trend for thyroid cancer was observed among both genders (APC, 4.9%; 95% CI, 3.2 to 6.6) and specifically among adolescents and those in the Northeast, South, and West regions of the United States. Renal carcinoma incidence was increasing significantly overall (APC, 5.4%; 95% CI, 2.8 to 8.1). Extracranial and extragonadal germ cell tumors and melanoma were both significantly decreasing. CONCLUSIONS This study reports the novel finding that renal carcinoma rates are increasing among children and adolescents. This study confirms that thyroid cancer rates are increasing and further describes rising cancer rates among African Americans.

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“…Based on United States National Cancer Institute Surveillance, Epidemiology and End Results (SEER) data from 1975 to 1995, RCC represents 32% of primary renal malignancies between the ages of 10 and 14 years and 63% between the ages of 15 and 19 years [1]. A review of the California Cancer Registry from 1988 through 2004 indicated that RCC comprises approximately 51% of primary renal malignancies in patients ages 11-20 years [2].…”

Section: Introductionmentioning

confidence: 99%

CT and MRI appearances and radiologic staging of pediatric renal cell carcinoma

et al. 2012

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Renal tumors in the second decade of life: results from the California Cancer Registry

Cited by 13 publications

References 26 publications

Renal Tumors in Children Aged 10–16 Years: A Report from the United Kingdom Children's Cancer and Leukaemia Group

Renal Tumors in Children Aged 10–16 Years: A Report from the United Kingdom Children's Cancer and Leukaemia Group

Cancer Incidence Rates and Trends Among Children and Adolescents in the United States, 2001–2009

CT and MRI appearances and radiologic staging of pediatric renal cell carcinoma

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