Renal ultrasonography is useful for evaluating diabetic renal failure

Nishimura, Masataka; Terawaki, Hiroyuki; Hoshiyama, Yoshiharu; Joh, Kensuke; Hamaguchi, K; Yamada, K

doi:10.5414/cnp59174

Cited by 8 publications

(3 citation statements)

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“…The kidneys are enlarged in diabetes mellitus when they have microalbuminuria or overt levels of albumin excretion [56]. A raised level of albumin in the urine is a typical indicator that the kidneys have been injured by diabetes [57]. Excess body weight has an adverse effect on the liver, and can increase the risk of the development of metabolic symptoms [58].…”

Section: Discussionmentioning

confidence: 99%

Antihypertriglyceridemia and Anti-Inflammatory Activities ofMonascus-Fermented Dioscorea in Streptozotocin-Induced Diabetic Rats

Shi

Liao

Pan

2011

Experimental Diabetes Research

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The rice fermented by Monascus, called red mold rice (RMR), and has a long tradition in East Asia as a dietary staple. Monascus-fermented dioscorea called red mold dioscorea (RMD) contains various metabolites to perform the ability of reducing oxidative stress and anti-inflammatory response. We used Wistar rats and induced diabetes by injecting streptozotocin (STZ, 65 mg/kg i.p.). RMD was administered daily starting six weeks after disease onset. Throughout the experimental period, significantly (P < .05) lowered plasma glucose, triglyceride, cholesterol, free fatty acid and low density lipoprotein levels were observed in the RMD-treated groups. The RMD-treated diabetic rats showed higher activities of glutathione disulfide reductase, glutathione reductase, catalase and superoxide dismutase (P < .05) in the pancreas compared with the diabetic control rats. RMD also inhibited diabetes-induced elevation in the levels of interleukin (IL)-1β, IL-6, interferon-γ and tumor necrosis factor-α. Pancreatic β-cells damaged by STZ in the RMD supplemented groups were ameliorated. The results of this study clearly demonstrated that RMD possesses several treatment-oriented properties, including the control of hyperglycemia, antioxidant effects, pancreatic β-cell protection and anti-inflammatory effects. Considering these observations, it appears that RMD may be a useful supplement to delay the development of diabetes and its complications.

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Section: Discussionmentioning

confidence: 99%

Antihypertriglyceridemia and Anti-Inflammatory Activities ofMonascus-Fermented Dioscorea in Streptozotocin-Induced Diabetic Rats

Shi

Liao

Pan

2011

Experimental Diabetes Research

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“…[13] Several authors indicated kidney volume, both absolute and relative, to be a more accurate measure of kidney mass that correlates better with glomerular filtration rate than kidney length. [20,21] Therefore, kidney volume calculated by the ellipsoid formula and kidney volume/BSA were included in the present study beside kidney length, the most frequently used measure of kidney size. However, logistic regression failed to confirm that kidney volume was more powerful than kidney length in differentiating BEN and BEN-suspected patients from healthy persons and those with other kidney diseases.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Criteria for the Diagnosis of Balkan Endemic Nephropathy

Djukanović

Marić²,

Marinković

et al. 2007

Renal Failure

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Background. The diagnosis of Balkan endemic nephropathy (BEN) is often made using Danilovic's criteria. The aim of this study was to determine the prevalence, sensitivity, specificity, and predictive value of Danilovic's criteria and several additional indices. Methods. The study included 19 BEN patients, 23 BEN-suspected patients, 34 patients with other kidney diseases, and 23 healthy controls. The sensitivity and specificity of Danilovic's criteria was calculated, and these criteria, in addition to age, sex, blood pressure, creatinine clearance, glucosuria, urine osmolality, alkaline phosphatase, alpha 1-microglobulin, fractional sodium excretion, tubular phosphate reabsorption, kidney length, and volume, were combined in a logistic regression. Results. All examined persons were from a BEN-affected village (criterion 1), and all BEN, BENsuspected patients, and 12/23 healthy controls were from BEN families (criterion 2). None of the remaining Danilovic's criteria was found in the healthy controls. The prevalence of proteinuria, low specific gravity, and anemia (criteria 3-5) differed insignificantly among the patient groups. Azotemia and shrunken kidney (criteria 6 and 7) were significantly more frequent in BEN than in other patients. Only proteinuria showed high sensitivity and specificity in differentiating BEN and BEN-suspected patients from healthy persons, but no criteria differentiated BEN or BEN-suspected from other kidney diseases. Proteinuria is a significant predictor of both BEN and BENsuspected vs. healthy persons, and alpha 1-microglobulinuria is a significant predictor of BEN vs. other kidney diseases. Conclusion. Danilovic's criteria enabled a diagnosis of BEN only in chronic renal failure and differential diagnosis between BEN and healthy persons but not between BEN and other kidney diseases. Out of the examined indices of proximal tubular disorders, only alpha 1-microglobulinuria significantly discriminated BEN from other kidney diseases.

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“…Kidney size is also an important parameter for clinical evaluation of kidney diseases. However, only a few studies have examined the changes of kidney dimensions in different kidney diseases, most frequently in patients with diabetes [4,5] and in elderly patients [6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

Comparison of Kidney Size between Patients with Balkan Endemic Nephropathy and Other Kidney Diseases

Lezaić¹,

Marić²,

Jovanović³

et al. 2008

Kidney Blood Press Res

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Background: The aim of this study was to assess the relationship between kidney dimensions and creatinine clearance (Ccr) in patients with Balkan endemic nephropathy (BEN), nephrosclerosis (NSc), glomerulonephritis (GN), diabetic nephropathy (DN) and in healthy persons. The main objective was to find out at which stage of BEN the kidneys start to shrink. Methods: The study involved 84 patients with BEN, 39 with NSc, 56 with GN, 55 with DN, and 52 healthy subjects, allocated to group 1 (n = 28) sex- and age-matched with BEN/NSc patients, or group 2 (n = 24) sex- and age-matched with GN/DN patients. Based on Ccr, patients were classified according to the NKF/DOQI guidelines. Results: The kidney dimensions of BEN patients in all stages of the disease were significantly shorter than those of healthy controls and patients with GN and DN. In stages 3–5, BEN patients had significantly smaller kidneys than patients with NSc. Patients with NSc had smaller kidney dimensions than controls and GN/DN patients but all of these differences were not significant. Conclusion: BEN patients had significantly smaller kidneys than sex- and age-matched healthy persons and patients with GN and DN in all stages of the disease and patients with NSc in stages 3–5 of the disease.

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Renal ultrasonography is useful for evaluating diabetic renal failure

Cited by 8 publications

References 0 publications

Antihypertriglyceridemia and Anti-Inflammatory Activities ofMonascus-Fermented Dioscorea in Streptozotocin-Induced Diabetic Rats

Antihypertriglyceridemia and Anti-Inflammatory Activities ofMonascus-Fermented Dioscorea in Streptozotocin-Induced Diabetic Rats

Evaluation of Criteria for the Diagnosis of Balkan Endemic Nephropathy

Comparison of Kidney Size between Patients with Balkan Endemic Nephropathy and Other Kidney Diseases

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