Renal Venous Thrombosis in Children

Reimold, Ekkehard W.; Wittel, R A

doi:10.1097/00007611-198310000-00021

Cited by 13 publications

(4 citation statements)

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“…138 Renal vein thrombosis: Both anticoagulant and thrombolytic therapy are controversial for RVT. 186 One approach is to use supportive care for unilateral RVT in the absence of uremia, and no extension into the IVC with careful monitoring of the RVT for extension. 138 For unilateral RVT that extends into the IVC anticoagula-tion therapy with UFH or LMWH is likely indicated.…”

Section: Treatment Venous Thromboembolic Eventsmentioning

confidence: 99%

Thromboembolic Disease and Antithrombotic Therapy in Newborns

Andrew¹,

Monagle²,

deVeber³

et al. 2001

Hematology

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This update uses an evidence based approach to analyze and present the epidemiology of neonatal thrombosis, etiologies, currently used techniques for diagnosis with their limitations, and current therapeutic approaches. In addition, the approaches to both prevention and optimal therapies are discussed.In Section I Dr. Paul Monagle addresses the epidemiology of neonatal thrombosis outside of the central nervous system in both arterial and venous locations, and those that occur in utero. The specific contributions of catheters and congenital prothrombotic disorders are delineated. Dr. Monagle also describes currently used techniques for the diagnosis of thrombotic events as well as their limitations and the current therapeutic approaches.In Section II, Dr. Gabrielle deVeber reviews the epidemiology of neonatal thrombosis within the central nervous system, in both arterial and venous locations and those that occur in utero. The neurological presentation, risk factors including congenital prothrombotic disorders, anatomical distribution, diagnostic tests, use of antithrombotic therapy and neurologic outcome of neonates with either sinovenous thrombosis or arterial ischemic stroke are discussed.In Section III, Dr. Anthony Chan reviews the current approaches to the prevention and treatment of neonatal thrombosis. Information on the differences in the response of neonates compared to adults to antithrombotic therapy and new approaches to the prevention and treatment of thrombosis in neonates are emphasized.Thromboembolic events (TEs) during childhood are increasing in their frequency and severity, and occur in children surviving previously life-threatening primary diseases. Newborns comprise the largest group of children developing TEs. This paper discusses the epidemiology, diagnostic tests, acquired and congenital prothrombotic risk factors, long-term outcomes, and antithrombotic therapy for the management of TEs in newborns. Due to the unique features and the significance of TEs in the central nervous system (CNS), sinovenous thrombosis (SVT) and arterial ischemic stroke (AIS) will be considered separately; cerebrovascular lesions in premature infants will not be discussed.In preparation for this manuscript, comprehensive Medline reviews were performed to identify all relevant publications, which were analyzed based upon the study design; results of studies with stronger designs were given more influence in the analysis. The striking features of this review were the deficiencies in our knowledge with respect to appropriate diagnostic strategies, optimal therapy for newborns with TEs, and the contribution of congenital prothrombotic disorders. Well-designed trials are required to improve our ability to care for neonates with TEs.

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Section: Treatment Venous Thromboembolic Eventsmentioning

confidence: 99%

Thromboembolic Disease and Antithrombotic Therapy in Newborns

Andrew¹,

Monagle²,

deVeber³

et al. 2001

Hematology

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“…Long-term functional impairments include hypertension and renal insufficiency. 4,5 Many imaging modalities have been employed, but ultrasound and color Doppler ultrasound are the techniques most commonly used in the evaluation of neonates with suspected RVT. 6 Although the etiology of RVT is not fully understood, predisposing factors for neonatal RVT include dehydration, sepsis, birth asphyxia, polycythemia, maternal diabetes, traumatic delivery, congenital renal vein defects, and an indwelling umbilical venous catheter.…”

Section: Introductionmentioning

confidence: 99%

Renal venous thrombosis in neonates: prothrombotic risk factors and long-term follow-up

Kosch¹,

Kuwertz-Bröking²,

Heller³

et al. 2004

Blood

143

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The present study was designed to evaluate prothrombotic risk profiles in 59 consecutively recruited white neonates with renal venous thrombosis (RVT). The rates of prothrombotic risk factors (PRs)-for example, the factor V (FV) 1691G>A mutation, the factor II ( Of the 59 neonates investigated, 53 revealed renal atrophy, and 13 children additionally suffered from severe arterial hypertension. In conclusion, the present study demonstrates the significance of genetic PR-especially the FV mutation and elevated Lp(a)-for the etiology of neonatal

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“…Perirenal hematoma is a very rare finding in neonates and may result from capsular distension and consequent rupture by generalized edema and hemorrhage of the kidney [ 7 ]. Adrenal hemorrhage occurs in 15% of the cases, by the same mechanism, more frequently on the left, where the left adrenal vein drains into the left renal vein [ 2 ].…”

Section: Commentsmentioning

confidence: 99%

Perinatal Renal Vein Thrombosis: Role of Imaging in the Initial Diagnosis

Forjaco Jorge,

Riesenberger,

Soares

2023

Journal of the Belgian Society of Radiology

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We report the case of a neonate who presented with a left abdominal flank mass and hemodynamic instability signs, with the final diagnosis of left renal vein thrombosis complicated with inferior vena cava thrombosis and perirenal hematoma. We illustrate the importance of an early imaging approach with ultrasound and Doppler evaluation to finally diagnose perinatal renal vein thrombosis and its complications. Teaching Point: An early imaging approach with ultrasound and Doppler evaluation is fundamental to finally diagnose perinatal renal vein thrombosis and its complications.

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Renal Venous Thrombosis in Children

Cited by 13 publications

References 0 publications

Thromboembolic Disease and Antithrombotic Therapy in Newborns

Thromboembolic Disease and Antithrombotic Therapy in Newborns

Renal venous thrombosis in neonates: prothrombotic risk factors and long-term follow-up

Perinatal Renal Vein Thrombosis: Role of Imaging in the Initial Diagnosis

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