Renalase is localized to the small intestine crypt and expressed upon the activation of NF-κB p65 in mice model of fasting-induced oxidative stress

Aoki, Kai; Yanazawa, Koki; Tokinoya, Katsuyuki; Sugasawa, Takehito; Suzuki, Takuji; Yoshida, Yasuko; Nakano, Takuro; Omi, Naomi; Kawakami, Yasushi; Takekoshi, Kazuhiro

doi:10.1016/j.lfs.2020.118904

Cited by 15 publications

(38 citation statements)

References 26 publications

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“…It also suggests that plasma levels may be relevant to acute injury responses. Environmental oxidative stress changed RNLS expression in small intestinal crypts and cultured transformed intestinal cells [9]. Similar to the liver, increasing RNLS levels (by transfection) reduced oxidative injury in cultured intestinal cells.…”

Section: Introductionmentioning

confidence: 89%

“…Tissue levels of RNLS can be regulated and this response is likely to modulate its biologic effects and as well as its roles in diseases involving acute injury and in cancer. Several factors (Figure 2) have been shown to upregulate RNLS gene expression including STAT3, Sp1, ZBP89, NF-κB, HIF-1α, and TNF-α in various tissues [9,37,38]. For STAT3, a positive feedback loop with RNLS has been suggested with STAT3 enhancing RNLS production and RNLS, in turn, increasing STAT3 activation [11,37].…”

Section: Rnls Cellular Expression Is Regulatedmentioning

confidence: 99%

“…Several factors (Figure 2) have been shown to upregulate RNLS gene expression including STAT3, Sp1, ZBP89, NF-κB, HIF-1α, and TNF-α in various tissues [9,37,38]. For STAT3, a positive feedback loop with RNLS has been suggested with STAT3 enhancing RNLS production and RNLS, in turn, increasing STAT3 activation [11,37].…”

Section: Rnls Cellular Expression Is Regulatedmentioning

confidence: 99%

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Renalase: A Multi-Functional Signaling Molecule with Roles in Gastrointestinal Disease

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Gorelick

Desir

2021

Cells

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The survival factor renalase (RNLS) is a recently discovered secretory protein with potent prosurvival and anti-inflammatory effects. Several evolutionarily conserved RNLS domains are critical to its function. These include a 20 aa site that encodes for its prosurvival effects. Its prosurvival effects are shown in GI disease models including acute cerulein pancreatitis. In rodent models of pancreatic cancer and human cancer tissues, increased RNLS expression promotes cancer cell survival but shortens life expectancy. This 37 kD protein can regulate cell signaling as an extracellular molecule and probably also at intracellular sites. Extracellular RNLS signals through a specific plasma membrane calcium export transporter; this interaction appears most relevant to acute injury and cancer. Preliminary studies using RNLS agonists and antagonists, as well as various preclinical disease models, suggest that the immunologic and prosurvival effects of RNLS will be relevant to diverse pathologies that include acute organ injuries and select cancers. Future studies should define the roles of RNLS in intestinal diseases, characterizing the RNLS-activated pathways linked to cell survival and developing therapeutic agents that can increase or decrease RNLS in relevant clinical settings.

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Section: Introductionmentioning

confidence: 89%

Section: Rnls Cellular Expression Is Regulatedmentioning

confidence: 99%

Section: Rnls Cellular Expression Is Regulatedmentioning

confidence: 99%

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Renalase: A Multi-Functional Signaling Molecule with Roles in Gastrointestinal Disease

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Gorelick

Desir

2021

Cells

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“…Paraffin-embedded tissue sections were prepared and stained with hematoxylin and eosin as previously described [12]. Antigen retrieval was also performed as previously described [12].…”

Section: Histochemical Staining and Immunohistochemistrymentioning

confidence: 99%

“…Digestion and absorption within the small intestine are required in order for the host organism to absorb nutrients from food. However, after clinical interventions involving fasting and total parenteral nutrition (TPN), the digestive and absorptive capability of the small intestine are remarkably compromised, a phenomenon that is associated with a decrease in the expression of nutrient digestion-and absorption-related genes [12,13]. To date, two studies have reported the effects of exercise on the expression of intestinal glucose transporters.…”

Section: Introductionmentioning

confidence: 99%

Acute Low-Intensity Treadmill Running Upregulates the Expression of Intestinal Glucose Transporters via GLP-2 in Mice

et al. 2021

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The effects of exercise on nutrient digestion and absorption in the intestinal tract are not well understood. A few studies have reported that exercise training increases the expression of molecules involved in carbohydrate digestion and absorption. Exercise was also shown to increase the blood concentration of glucagon-like peptide-2 (GLP-2), which regulates carbohydrate digestion and absorption in the small intestine. Therefore, we investigated the effects of exercise on the expression of molecules involved in intestinal digestion and absorption, including GLP-2. Six-week-old male mice were divided into a sedentary (SED) and low-intensity exercise (LEx) group. LEx mice were required to run on a treadmill (12.5 m/min, 1 h), whereas SED mice rested. All mice were euthanized 1 h after exercise or rest, and plasma, jejunum, ileum, and colon samples were collected, followed by analysis via IHC, EIA, and immunoblotting. The levels of plasma GLP-2 and the jejunum expression of the GLP-2 receptor, sucrase-isomaltase (SI), and glucose transporter 2 (GLUT2) were higher in LEx mice. Thus, we showed that acute low-intensity exercise affects the expression of molecules involved in intestinal carbohydrate digestion and absorption via GLP-2. Our results suggest that exercise might be beneficial for small intestine function in individuals with intestinal frailty.

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Cyclic-AMP response element binding protein (CREB) and microRNA miR-29b regulate renalase gene expression under catecholamine excess conditions

Iyer,

Arige,

Ananthamohan

et al. 2023

Life Sciences

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Renalase is localized to the small intestine crypt and expressed upon the activation of NF-κB p65 in mice model of fasting-induced oxidative stress

Cited by 15 publications

References 26 publications

Renalase: A Multi-Functional Signaling Molecule with Roles in Gastrointestinal Disease

Renalase: A Multi-Functional Signaling Molecule with Roles in Gastrointestinal Disease

Acute Low-Intensity Treadmill Running Upregulates the Expression of Intestinal Glucose Transporters via GLP-2 in Mice

Cyclic-AMP response element binding protein (CREB) and microRNA miR-29b regulate renalase gene expression under catecholamine excess conditions

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