Renatured hydrogel painting

Abstract

Hydrogel coatings pave an avenue for improving the lubricity, biocompatibility, and flexibility of solid surfaces. From the viewpoint of practical applications, this work establishes a scalable method to firmly adhere hydrogel layers to diverse solid surfaces. The strategy, termed as renatured hydrogel painting (RHP), refers to adhering dehydrated xerogel to a surface with appropriate glues, followed by the formation of a hydrogel layer after rehydration of the xerogel. With the benefits of simplicity and generality, this strategy can be readily applied to different hydrogel systems, no matter what the substrate is. Hydrogel adhesion is demonstrated by its tolerance against mechanical impact with hydrodynamic shearing at 14 m/s. This method affords powerful supplements to renew the surface chemistry and physical properties of solid substrates. In addition, we show that the RHP technique can be applied to living tissue, with potential for clinical applications such as the protection of bone tissue.

Visible-Light-Mediated Nano-biomineralization of Customizable Tough Hydrogels for Biomimetic Tissue Engineering

“…This change would be desirable in applications such as joint repair because reduced friction would enhance the lubrication performance at interfaces (Figure S23). ,, …”

“…This change would be desirable in applications such as joint repair because reduced friction would enhance the lubrication performance at interfaces (Figure S23). 20,50,51 The feasibility of producing BTHs with customizable designs was evaluated because clinical applications will require various 2D or 3D structures. The rheological characterization was used to monitor the gelation of BTH specimens in response to light irradiation.…”

“…Nowadays, millions of people suffer from defects, dysfunctions, and pathological changes of tissues and organs every year. Tissue engineering has been demonstrated as a powerful means of relieving these patients’ physical and psychological distress by considering all merits from cytobiology, materials science, and bionics. − Material matrices are indispensable parts in this field and play critical roles in repairing, improving, or regenerating tissues and organs. − Typically, soft, porous hydrogels containing high concentrations of water are able to mimic extracellular matrices and provide similar microenvironments for cell proliferation, nutrition delivery, and tissue generation. − These materials can also be combined with other functional components to improve properties such as adhesion, , conductivity, , stimuli responsiveness, , and other abilities. − Particularly, so-called biomineralized tough hydrogels (BTHs) containing bioactive inorganic compounds can exhibit significantly improved mechanical performance and biological properties and therefore have applications in the fields of soft bioelectronics and tissue engineering. − …”

A Universal Strategy for Growing a Tenacious Hydrogel Coating from a Sticky Initiation Layer

“…[11] Furthermore, a concept of renatured hydrogel painting was proposed to decorate uniform hydrogel coatings on tangible surfaces. [12] The SCIRP method entails the iron catalyst to be doped into the substrates beforehand, while the inherent properties of the substrates would suffer some change. [9] The surface photo/thermal-initiation method proposed by Zhao et al is currently a trending research topic that enables the modification of hydrogel coatings on the surfaces of a wide range of medical devices and soft robots.…”

Electrostatic Induced Peptide Hydrogels for pH‐Controllable Doxorubicin Release and Antitumor Activity

“…As hydrophilic material with a three‐dimensional porous structure, hydrogels have been widely used since the high water content and modifiable structure [1–7] . Common polymer hydrogels are limited in biomedical applications due to their low biocompatibility [8] .…”