This study evaluates the vapor transportation by transmission pipelines during seawater desalination. This study seeks to reach a high rate of water transportation during desalination. Hence, the results obtained from this research are closer to reality than other analyses. Other benefits of this research include increasing efficiency, studying the element-to-element transmission, and considering flow as a compression case. The water desalination system comprises three parts of evaporation, transportation, and condensation. In the transportation part, equations of continuity, momentum, and energy are implemented, and the temperature of the vapor is calculated at the beginning of the condensation pipe. Other achievements of this study include the division of transportation lines to small elements and the implementation of vapor condensation in transportation lines. This study used pipelines with diameters of 1, 2, and 4 m to transmit vapor to Ramsar city and the heights of Takhte Soleiman, 16 km away from the city with the elevation of 2000 m. The results show that diameter, transportation length, and temperature differences are, respectively, the most influential factors on the efficiency of sub-atmospheric vapor transportation. The outcomes of this study were presented as the outflow of condensed water at the destination. Considering the margin of safety in calculations, it was scientifically proved that the results obtained in this study were approximately 10% more than results derived from other studies in the literature that are based on the incompressibility of fluids.