Renewal of the Major Fields of New-Generation Computing

Groppe, Sven

doi:10.1007/s00354-023-00206-5

Cited by 1 publication

(1 citation statement)

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“…We then used two-sample t-tests (N t-tests= number of neurons x number of behaviors) to determine whether the differences in mean firing rate as calculated by Cohen's d were statistically significant (Fig S2C). To control for false positives, we used Benjamini & Hochberg's (1995) false detection rate (FDR) procedure 78 as implemented in the Matlab function fdr_bh 79 and used FDR-corrected P-value of 0.01 as a significance threshold. We considered a unit's activity to be significantly modulated by a behavior if FDR-corrected P-value<0.01 (Fig 2F).…”

Section: Single Unit Responses Across Macaques' Natural Behavioral Re...mentioning

confidence: 99%

Neural signatures of natural behavior in socializing macaques

Testard

Tremblay

Parodi

et al. 2023

Preprint

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Our understanding of the neurobiology of primate behavior largely derives from artificial tasks in highly-controlled laboratory settings, overlooking most natural behaviors primate brains evolved to produce1. In particular, how primates navigate the multidimensional social relationships that structure daily life and shape survival and reproductive success remains largely unexplored at the single neuron level. Here, we combine ethological analysis with new wireless recording technologies to uncover neural signatures of natural behavior in unrestrained, socially interacting pairs of rhesus macaques within a larger colony. Population decoding of single neuron activity in prefrontal and temporal cortex unveiled robust encoding of 24 species-typical behaviors, which was strongly modulated by the presence and identity of surrounding monkeys. Male-female partners demonstrated near-perfect reciprocity in grooming, a key behavioral mechanism supporting friendships and alliances, and neural activity maintained a running account of these social investments. When confronted with an aggressive intruder, behavioral and neural population responses reflected empathy and were buffered by the presence of a partner. Surprisingly, neural signatures in prefrontal and temporal cortex were largely indistinguishable and irreducible to visual and motor contingencies. By employing an ethological approach to the study of primate neurobiology, we reveal a highly-distributed neurophysiological record of social dynamics, a potential computational foundation supporting communal life in primate societies, including our own.

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Section: Single Unit Responses Across Macaques' Natural Behavioral Re...mentioning

confidence: 99%