DOI: 10.58837/chula.the.2022.290
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Renieramycin t derivative dh_22 induces apoptosis in lung cancer cells by downregulation of C-Myc protein

Indiana Anggraeni

Abstract: Lung cancer is a prevalent cause of death, indicated by an elevated c-Myc level. We synthesized a new derivative of renieramycin T (RT), named DH_22, and tested it for anti-cancer activities in human lung cancer cells. In the cell viability and nuclear staining tests, DH_22 was discovered to be cytotoxic, with an IC50�of around 13�?M; and found to mediate apoptosis in the lung cancer cells. Meanwhile, in a mechanistic sense, DH_22 contributed to the activation of p53-dependent apoptosis and decreased the cellu… Show more

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