Renin activity and norepinephrine, cation, and water contents of cardiovascular tissue of dogs with congestive heart failure and ascites

Abstract

1970. Renin activity and norepinephrine, cation, rind water contents sf cardiovascular tissue of dogs with congestive heart failure and ascites. Can. J. Physiol. Pharnaacol. 48, 463468. Six dogs with congestive heart failure and ascites were studied for ( a ) renin, norepinephrine, water, sodium, potassium, calcium. and lrnagnesium contents in cardiovascular tissues; ( h ) plasma renin activity and renin substrate; ( c ) renal renin activity, juxtaglomerular index, and glucose-6-phosphate dehydrogenase activity in macula densa cells, and a-glycero-6-phosphate dehydrogenase activity in inacula densa cells and juxtaglonaerular bodies. The most important findings were: (a) a cignificant decrease in renal renin activity and in the juxtaglomcrular index coinciding with increased activities of glucose-6-phosphate and a-glycero-6-phosphate dehydrogenases in nnacula dens2 cells when compared with normal renal hissue: ( b ) a highly significant increase in norepinephrine content in branches of mesenteric veins combined with a decrease in norepinephrine content in most arteries studied; ( c ) a significant increase in the sodium content of most arteries studied, without any change h water content.

Partial Characterization of Aortic Renin in the Spontaneously Hypertensive Rat and its Interrelationship with Plasma Renin, Blood Pressure and Sodium Balance

“…SH rat by manipulation of dietary sodium confirms the results of others (Aoki, Yamori, Ooshima & Okamoto, 1972). A significant increase in arterial renin content of the dog has also been observed after sodium restriction (Hayduk et al, 1970b). In the present study, plasma renin did not fall in animals receiving a high sodium diet.…”

“…The presence of renin-like enzymes has been reported in arterial tissue from hog (Gould, Skeggs & Kahn,1964), rat (Genest, Simard, Rosenthal & Boucher, 1969) and dog (Hayduk, Brecht, Vladutiu, Simard, Rojo-Ortega, Belleau, Boucher & Genest, 1970b). Although there is some controversy as to whether or not a true renin-like enzyme exists in extrarenal tissues (Day & Reid, 1976), it has been demonstrated (Gould et al, 1964) that the renin-like enzyme of hog aortic tissue, partially purified by salt precipitation, has the same p H optimum and reaction kinetics as the kidney enzyme.…”

The Mechanism of Adaptation of Left Atrial Stretch Receptors in Dogs with Chronic Congestive Heart Failure

“…The etiology of the altered fluid balance in CHF can be attributed to both hemodynamic (1,3,5,7) and hormonal factors (4,(8)(9)(10)(11). Evidence has been presented by several investigators that the secretion of antidiuretic hormone (ADH) may be altered during CHF or related disease states (12)(13)(14)(15)(16)(17)(18)(19).…”

Adrenergic Control of the Peripheral Circulation in Cardiomyopathic Hamsters with Heart Failure

“…Our observation that vascular resistance was reduced in hamsters with heart failure but not in hamsters with myopathy alone is consistent with this suggestion and presents the possibility that absence of augmented activity of terminal vascular sympathetic nerve endings may be characteristic of this model of heart failure or various other models of "highoutput" failure but not of the more common forms of 'low-output" failure with high vascular resistance However, several observations in other models of heart failure make this possibility unlikely. Hayduk et al (9) have reported that in dogs with lowoutput failure produced by tricuspid avulsion the norepinephrine content of arteries is normal or decreased. Furthermore, recent studies by Schmid et al (20) have indicated that resting sympathetic tone of blood vessels in the extremity is normal in dogs with heart failure and that responses to direct nerve stimulation are normal or reduced.…”