Renin, Aldosterone, and Serum-Converting Enzyme Activity during Normal and Hypertensive Pregnancy

Dux, Shlomo; Yaron, Avraham; Carmel, Amos; Rosenfeld, Joseph B.

doi:10.1159/000299158

Cited by 12 publications

(7 citation statements)

References 14 publications

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“…There are conflicting results on the relationship of ACE activities with pregnancy-induced hypertension or preeclampsia and chronic hypertension superimposed on pregnancy-induced hypertension (19, 20). Plasma ACE level has been associated with the insertion/deletion (I/D) polymorphism in intron 16 of the ACE gene (15).…”

Section: Discussionmentioning

confidence: 99%

Association of Angiotensin-Converting Enzyme and Angiotensinogen Gene Polymorphisms with Preeclampsia

et al. 2004

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We tested the hypothesis that angiotensin-converting enzyme (ACE) and angiotensinogen gene polymorphism influence the incidence, development and outcome of preeclampsia. Subjects were recruited from 90 Korean patients with preeclampsia during pregnancy and 98 age-matched controls. After isolation of DNA, polymerase chain reactions (PCR) were carried out to detect polymorphism of the ACE and angiotensinogen. M235T and T174M genotypes of angiotensinogen were determined by digestion with restriction enzyme endonuclease Tth 111-I and NCo I, respectively. The frequency of DD genotype was significantly greater in preeclampsia (0.36) than in controls (0.14) (p<0.05). The frequency of D allele was 0.55 in preeclampsia and 0.40 in controls (p<0.05). There were no differences in the onset of preeclampsia and pregnancy outcomes according to the ACE genotypes. There was no difference in the frequency of a allele of angiotensinogen M235T between the groups (0.79:0.78 in preeclampsia : controls). The frequency of T allele of angiotensinogen T174M gene was slightly increased, but not significantly, in preeclampsia (0.11) than in controls (0.07). In a multivariate analysis, only ACE genotype was associated with the development of preeclampsia (β=0.27, p=0.05). In conclusion, a molecular variant of ACE, but not angiotensinogen, gene is associated with preeclampsia in Korean women.

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Section: Discussionmentioning

confidence: 99%

Association of Angiotensin-Converting Enzyme and Angiotensinogen Gene Polymorphisms with Preeclampsia

et al. 2004

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“…One novelty of this study attains to the fact that the circadian rhythm for serum ACE activity has now received a documentation for physiologic pregnancy, even though the parameters of its oscillation appear to be peculiar because of a reduction It must be repeated that nonchronobiological studies demonstrated the morning levels of serum ACE activity to be decreased less than expected in pregnancy complicated by pre-eclampsa [16,17]. To this back ground, the present study adds the notion that serum ACE activity in pre-eclampsia syndrome has no rhythmic excursion and remains inappropriately elevated during the 24 h.…”

Section: Discussionmentioning

confidence: 99%

“…Blood sampling in gravidas was performed at the third tri mester of gestation (week [34][35][36][37][38], knowing that serum ACE activity exhibits poor changes during the first and second gestational trimester [15][16][17]. Pregnant women investigated were both primigravid and mul tigravid, considering that parity is not a deterministic factor for the activity of serum ACE [16].…”

Section: Subjects and Protocolmentioning

confidence: 99%

Serum Angiotensin-Converting Enzyme Activity in Pre-Eclamptic Pregnancy: Evidence for a Relative HypermesorACEemia

Cugini¹,

Letizia²,

Palma³

et al. 1990

Enzyme

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The circadian rhythm of serum angiotensin-converting enzyme (ACE) activity was investigated in pregnant women with normal and pre-eclamptic gestation. The chronobiological approach was able to document the occurrence of a circadian rhythm for serum ACE activity in normal pregnancy. Such a rhythm is characterized by a decreased mesor and amplitude and a shifted crest. The circadian rhythm for serum ACE activity was not detectable in pre-eclamptic pregnancy. Such an abrogation is accompanied by a negligible decrease of mesor suggesting the occurrence of a relative hyperACEemia. This disorder could play a role in pregnancy-induced hypertension.

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“…The recognition that the level of aldosterone fluctuates considcrably hclps to explain thc very wide ranges of plasma aldosterone concentrations that have been reported (Ledoux et al 1975;Dux et al 1984;Fcw et al 1986a) and the poor correlation with plasma renin activity and angiotensin-11 Concentration (Weir et al 1975). The diurnal pattern of saliva aldosterone in pregnancy shows the same variability that we have found in non-pregnant subjects (Few et al 1987) but in pregnancy thc peaks of saliva aldostcronc arc 5-10 times higher.…”

Section: Discussionmentioning

confidence: 99%

Aldosterone is secreted intermittently during pregnancy

Stevens

Paintin

Few

1989

BJOG

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Summary. Saliva aldosterone concentration was measured in samples collected at hourly intervals from healthy pregnant women (approximately 26 and 36 weeks gestation) who were going about their normal daily activities, and from some women hospitalized for disorders of pregnancy. In the healthy women diurnal saliva aldosterone fluctuated considerably, the highest values being 2–22 times the lowest on a given day. Because of the known correlation between saliva and plasma aldosterone concentrations we believe that the fluctuating salivary level is indicative of fluctuating plasma levels and that this is due to the intermittent secretion of aldosterone. The rate of decline of saliva aldosterone from peak levels indicated a half life (t½) of 72 (SD 31) min which was not significantly different from that in non‐pregnant subjects. The temporal pattern of saliva aldosterone suggests an enhanced response of the zona glomerulosa to the factors that cause aldosterone secretion to fluctuate in non‐pregnant subjects, rather than the development of a more potent stimulus to the zona glomerulosa during pregnancy. In addition to hour‐to‐hour variation there is also substantial day‐to‐day variation, so that estimation of aldosterone in a single sample of saliva or plasma is of little value during pregnancy. The mean diurnal aldosterone concentration can be estimated from five saliva samples so this measurement presents a convenient technique for the assessment of aldosterone status in pregnancy. In contrast to healthy pregnancy, a patient with pre‐eclampsia at 39 weeks gestation showed no elevation of saliva aldosterone above non‐pregnant levels at any time during the day.

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Renin, Aldosterone, and Serum-Converting Enzyme Activity during Normal and Hypertensive Pregnancy

Cited by 12 publications

References 14 publications

Association of Angiotensin-Converting Enzyme and Angiotensinogen Gene Polymorphisms with Preeclampsia

Association of Angiotensin-Converting Enzyme and Angiotensinogen Gene Polymorphisms with Preeclampsia

Serum Angiotensin-Converting Enzyme Activity in Pre-Eclamptic Pregnancy: Evidence for a Relative HypermesorACEemia

Aldosterone is secreted intermittently during pregnancy

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