Renin Angiotensin Aldosterone Axis, Including Aldosterone Binding Globulin and Blood Pressure in Three Species of Nonhuman Primates

Abstract

Variables of renin‐angiotensin‐aldosterone axis with inclusion of protein binding to specific plasma globulin (ABG), plasma cortisol, and the blood pressure (BP) were measured in 24 chimpanzees, 4 gorillas, and 16 cynomolgus monkeys. ABG activity was readily detected in plasma from the primates. In chimpanzees and gorillas, all the variables under baseline conditions were similar to those in humans. In cynomolgus (Macaca fascicularis), both the ABG binding capacity for aldosterone and the diastolic or systolic BP were significantly higher (p < 0.001 and p < 0.01 respectively) than in chimpanzees and gorillas.