Renin-angiotensin aldosterone inhibitor use at hospital discharge among patients with moderate to severe acute kidney injury and its association with recurrent acute kidney injury and mortality

Siew, Edward D.; Parr, Sharidan K.; Abdel-Kader, Khaled; Perkins, Amy M.; Greevy, Robert A.; Vincz, Andrew J.; Denton, Jason; Wilson, Otis; Hung, Adriana M.; İkizler, T. Alp; Robinson‐Cohen, Cassianne; Matheny, Michael E.

doi:10.1016/j.kint.2020.08.022

Cited by 27 publications

(19 citation statements)

References 34 publications

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“…Receipt of RASi therapy within 6 months after hospital discharge was associated with reduced mortality with no difference in ESKD. This beneficial effect of RASi on mortality in patients with AKI was confirmed in another study [61]. In addition to the beneficial role of using RASi on mortality in patients with AKI, Chou et al reported that among patients who had cardiac surgery-associated AKI (n= 587), the use of RASi was associated with a lower risk of ensuing CKD [62].…”

Section: Medications 231 Renin Angiotensin Inhibitors (Rasi)mentioning

confidence: 70%

Determinants of Outcomes of Acute Kidney Injury: Clinical Predictors and Beyond

Abdel‐Rahman

Turgut

Gautam

et al. 2021

JCM

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Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid impairment of kidney function. The incidence of AKI and its severe form AKI requiring dialysis (AKI-D) has been increasing over the years. AKI etiology may be multifactorial and is substantially associated with increased morbidity and mortality. The outcome of AKI-D can vary from partial or complete recovery to transitioning to chronic kidney disease, end stage kidney disease, or even death. Predicting outcomes of patients with AKI is crucial as it may allow clinicians to guide policy regarding adequate management of this problem and offer the best long-term options to their patients in advance. In this manuscript, we will review the current evidence regarding the determinants of AKI outcomes, focusing on AKI-D.

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Section: Medications 231 Renin Angiotensin Inhibitors (Rasi)mentioning

confidence: 70%

Determinants of Outcomes of Acute Kidney Injury: Clinical Predictors and Beyond

Abdel‐Rahman

Turgut

Gautam

et al. 2021

JCM

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“… [326] Having said this, discontinuing ACE inhibitors or ARB's after hospitalization specifically for acute kidney injury may be associated with a higher risk of post discharge mortality. [ 327 , 328] In non-dialysis patients with eGFR < 30 mg/min/1.73 m 2 , loop diuretics are preferred over thiazide diuretics. Torsemide generally has more predictable bioavailability compared to furosemide.…”

Section: Kidney Dysfunctionmentioning

confidence: 99%

Ten things to know about ten cardiovascular disease risk factors

Bays

Taub

Epstein

et al. 2021

American Journal of Preventive Cardiology

150

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Given rapid advancements in medical science, it is often challenging for the busy clinician to remain up-to-date on the fundamental and multifaceted aspects of preventive cardiology and maintain awareness of the latest guidelines applicable to cardiovascular disease (CVD) risk factors. The “American Society for Preventive Cardiology (ASPC) Top Ten CVD Risk Factors 2021 Update” is a summary document (updated yearly) regarding CVD risk factors. This “ASPC Top Ten CVD Risk Factors 2021 Update” summary document reflects the perspective of the section authors regarding ten things to know about ten sentinel CVD risk factors. It also includes quick access to sentinel references (applicable guidelines and select reviews) for each CVD risk factor section. The ten CVD risk factors include unhealthful nutrition, physical inactivity, dyslipidemia, hyperglycemia, high blood pressure, obesity, considerations of select populations (older age, race/ethnicity, and sex differences), thrombosis/smoking, kidney dysfunction and genetics/familial hypercholesterolemia. For the individual patient, other CVD risk factors may be relevant, beyond the CVD risk factors discussed here. However, it is the intent of the “ASPC Top Ten CVD Risk Factors 2021 Update” to provide a succinct overview of things to know about ten common CVD risk factors applicable to preventive cardiology.

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“…However, the mechanisms might be divided into specific and unspecific mechanisms [ 23 , 24 , 117 ]. Among the specific mechanisms are the direct invasion of renal parenchyma by SARS-CoV-2 and the imbalance of the renin-angiotensin-aldosterone system (RAAS) with generation of inflammatory mediators, oxidative stress and microthrombosis [ 125 , 126 ]. The viral invasion of renal tissue has been described as an important mechanism for the development of virus-associated kidney injury [ 126 , 127 ].…”

Section: Covid-19 and Acute Kidney Injury (Aki)mentioning

confidence: 99%

Catechins: Therapeutic Perspectives in COVID-19-Associated Acute Kidney Injury

Diniz¹,

Elshabrawy

Souza

et al. 2021

Molecules

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Data obtained from several intensive care units around the world have provided substantial evidence of the strong association between impairment of the renal function and in-hospital deaths of critically ill COVID-19 patients, especially those with comorbidities and requiring renal replacement therapy (RRT). Acute kidney injury (AKI) is a common renal disorder of various etiologies characterized by a sudden and sustained decrease of renal function. Studies have shown that 5–46% of COVID-19 patients develop AKI during hospital stay, and the mortality of those patients may reach up to 100% depending on various factors, such as organ failures and RRT requirement. Catechins are natural products that have multiple pharmacological activities, including anti-coronavirus and reno-protective activities against kidney injury induced by nephrotoxic agents, obstructive nephropathies and AKI accompanying metabolic and cardiovascular disorders. Therefore, in this review, we discuss the anti-SARS-CoV-2 and reno-protective effects of catechins from a mechanistic perspective. We believe that catechins may serve as promising therapeutics in COVID-19-associated AKI due to their well-recognized anti-SARS-CoV-2, and antioxidant and anti-inflammatory properties that mediate their reno-protective activities.

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Renin-angiotensin aldosterone inhibitor use at hospital discharge among patients with moderate to severe acute kidney injury and its association with recurrent acute kidney injury and mortality

Cited by 27 publications

References 34 publications

Determinants of Outcomes of Acute Kidney Injury: Clinical Predictors and Beyond

Determinants of Outcomes of Acute Kidney Injury: Clinical Predictors and Beyond

Ten things to know about ten cardiovascular disease risk factors

Catechins: Therapeutic Perspectives in COVID-19-Associated Acute Kidney Injury

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