Renin Angiotensin Aldosterone System Functions in Renovascular Hypertension

Gómez, José A.

doi:10.5772/intechopen.97491

Cited by 3 publications

(2 citation statements)

References 138 publications

(169 reference statements)

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“…One of the causative factors is hypertension of kidney origin. In the pathogenesis of hypertension of renal origin and renal damage, the renin-angiotensin-aldosterone system (RAAS) plays a crucial role [12,13]. Restriction of blood flow to the kidney, at least 75% reduction in the diameter of the renal artery, causes the release of renin in the contralateral kidney due to stimulation of the renal nerve [14].…”

Section: Pathophysiology Of Renal Hypertensionmentioning

confidence: 99%

Untitled

2023

Adv J Uro Nephro

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Purpose: This article highlighted renal denervation (RDN) in the treatment of resistant renal hypertension, with a minor emphasis on other methods. Materials and Methods: Hypertension (HT) remains a major public health problem. The estimated incidence in 2023 among 30-79-year-olds is around 1.28 billion. Kidney disease (KD) and HT are intrinsically linked and severely affect each other. Narrowing of the renal artery, mainly due to the formation of atherosclerotic plaques and secondary to fibromuscular dysplasia, causes an elevation in renal and systemic blood pressure (BP). Despite the combined use of 3 different classes of antihypertensive drugs, the mean blood pressure sometimes remains ≥ 140/90 mm Hg. In these cases, which are called resistant HT, surgical methods such as bypass grafting and endarterectomy or angioplasty with or without a stent are used to achieve renal revascularization. Another promising treatment modality is RDN. Results: Radiofrequency ablation (RFA), ultrasound, or neurotoxin injection are the most commonly used approaches for renal denervation. As INVAMED (Ankara, Turkey), we have developed an RDN device system (Delta Ⓡ Modulator Renal Denervation for Hypertension). Conclusion:Although there are exceptions in terms of efficacy in reports, RDN systems are rapid and have resulted in safe and sustained reduction in blood pressure.

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Section: Pathophysiology Of Renal Hypertensionmentioning

confidence: 99%

Untitled

2023

Adv J Uro Nephro

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“…7 Prostaglandins help in the regulation of renal function and hemodynamics through their effects on the renin-angiotensin system. 8 In this process synthesis of angiotensin II increase and aldosterone thereby increasing sodium and water reabsorption. Renin causes an increase in blood pressure with the effect of vasoconstriction by angiotensin II.…”

Section: Introductionmentioning

confidence: 99%

Effect of Celecoxib and Diclofenac on Blood Pressure, Renal Function and Vasoactive Prostanoids in Young Early Subjects

Arjumand¹,

Slam²,

Perveen³

et al. 2022

PJMHS

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Objective: Determination of celecoxib and diclofenac effects in early young subjects. Study design: Randomized study designed Methodology: All the participants received celecoxib 225 mg two times/day and diclofenac 80mg two times/day. First 21 days all participants received celecoxib treatment, before the start of the following medicine diclofenac 3.5 weeks gap was given. The blood pressure (BP) of patients was measured using the ambulatory blood pressure monitoring device (space labs model 90217A). Results: Group one consisted of young participants had a mean ± SD age 29 ± 3.4 while group 2 elderly had a mean ± SD age 55 ± 5.5. The mean body mass index was (group 1) 21.7 ± 1.8 kg/m2 and for group 2 = 27.3 ± 1.0 kg/m2. Group one had 5 (38.46%) females and 8 (61.53%) males while group 2 had 4 (30.76%) females and 9 (69.23%) males. The celecoxib medication baseline BP shows that there was no significant difference found in systolic blood pressure. Similar results for diastolic (mm Hg) for day and night time. Mean arterial pressure was higher in the elderly group -2 than in young group 1, Plasma renin activity was less in group 2 on day one compared to group 1. Plasma renin activity and concentration were decreased after 7 days of celecoxib and diclofenac treatment. A non-significant result was obtained. Group 1 Aldosterone serum (ng/l) for celecoxib received patients 11 ± 2.2 (ng/l) value for day one, day 7 = 13.2 ± 3.2, day 14 = 14.2 ± 3.4. Similarly in the case of diclofenac, the Aldosterone serum (ng/l) value for day one = 11.3 ± 21, day 7= 12.2 ± 2.3, and day 14 = 12.3 ± 2.1. A decrease in values was observed in both groups for aldosterone serum. For group-2 celecoxib, day one=15 ± 2.2, day 7= 14 ± 2.4*. day14= 14 ± 1.4. For diclofenac day one 15 ± 2.2, 7day= 15 ± 1.5, and 14 days = 14 ± 5.1. The comparison of both groups shows that the sodium and potassium decrease in both treatments in both groups. Conclusion: Overall, we got a non-significant response of both drugs on renal function and blood pressure. Keywords: blood pressure, renin angiotensin aldosterone system, non-steroidal anti-inflammatory drugs (NSAIDs)

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When Revascularization May Be Appropriate in Atherosclerotic Renal Artery Stenosis

Zarrella,

Wynne,

Smith

et al. 2024

Cureus

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Renal artery stenosis (RAS) is a condition that involves the narrowing of one or both renal arteries, most commonly caused by either atherosclerosis or fibroplasia. RAS can present in a multitude of clinical manifestations involving hypertension (HTN), heart failure, and renal failure. Current recommendations for treating patients with RAS involve strict medical therapy often without invasive therapies. However, in more complicated patients with RAS, recent clinical studies and guidelines have offered varying recommendations, which has presented challenges in managing these cases. This review aims to summarize current evidence to best evaluate which patients with RAS may benefit from renal artery revascularization as opposed to medical therapy alone.

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Renin Angiotensin Aldosterone System Functions in Renovascular Hypertension

Cited by 3 publications

References 138 publications

Untitled

Untitled

Effect of Celecoxib and Diclofenac on Blood Pressure, Renal Function and Vasoactive Prostanoids in Young Early Subjects

When Revascularization May Be Appropriate in Atherosclerotic Renal Artery Stenosis

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