Renin-angiotensin system activation and imbalance of matrix metalloproteinase-9/tissue inhibitor of matrix metalloproteinase-1 in cold-induced stroke

Su, Yuying; Li, Huanmin; Yan, Zhenxing; Li, Mingchun; Wei, Ji-peng; Zheng, Wenxia; Liu, Siqin; Deng, Yi; Xie, Huifang; Li, Chunguang

doi:10.1016/j.lfs.2019.116563

Cited by 16 publications

(14 citation statements)

References 54 publications

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“… 27 The use of a RAAS antagonist has been shown to modulate MMPs and TIMP‐1 in vitro and in animal models. 14 In our study, SBP was associated with collagen deposition (PICP levels), in agreement with this concept. Laviades et al studied a small cohort of White, Spanish hypertensive patients before and after receiving lisinopril.…”

Section: Discussionsupporting

confidence: 90%

“… 12 Specifically, MMP‐9 and TIMP‐1 are known to be involved in models of cardiac disease. 13 Previous studies have indicated that Ang II could stimulate vascular smooth muscle cells, endothelial cells, and extracellular matrix (ECM) of cerebral vessels to secrete MMP‐9, 11 , 14 , 15 an effect that was prevented by using captopril. 14 Cardiac myocytes are known to release large amounts of MMP‐1.…”

Section: Introductionmentioning

confidence: 99%

“… 13 Previous studies have indicated that Ang II could stimulate vascular smooth muscle cells, endothelial cells, and extracellular matrix (ECM) of cerebral vessels to secrete MMP‐9, 11 , 14 , 15 an effect that was prevented by using captopril. 14 Cardiac myocytes are known to release large amounts of MMP‐1. In addition, MMP‐1 and TIMP‐1 play a role in maintaining the ECM architecture.…”

Section: Introductionmentioning

confidence: 99%

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Angiotensin‐converting enzyme inhibitors increase anti‐fibrotic biomarkers in African Americans with left ventricular hypertrophy

Romero

Mathew

Wasinski

et al. 2021

J of Clinical Hypertension

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Angiotensin-converting enzyme inhibitors (ACEi) are part of the indicated treatment in hypertensive African Americans. ACEi have blood pressure-independent effects that may make them preferred for certain patients. We aimed to evaluate the impact of ACEi on anti-fibrotic biomarkers in African American hypertensive patients with left ventricular hypertrophy (LVH). We conducted a post hoc analysis of a randomized controlled trial in which hypertensive African American patients with LVH and vitamin D deficiency were randomized to receive intensive antihypertensive therapy plus vitamin D supplementation or placebo. We selected patients who had detectable lisinopril (lisinopril group) in plasma using liquid-chromatography/mass spectrometry analysis and compared them to subjects who did not (comparison group) at the oneyear follow-up. The pro-fibrotic marker type 1 procollagen C-terminal propeptide (PICP) and the anti-fibrotic markers matrix metalloproteinase-1 (MMP-1), tissue inhibitor of metalloproteinases 1 (TIMP-1), telopeptide of collagen type I (CITP), and N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) peptide were measured. Sixty-six patients were included, and the mean age was 46.2 ± 8 years. No difference was observed in the number and intensity of antihypertensive medications prescribed in each group. Patients with detectable lisinopril had lower blood pressure than those in the comparison group. The anti-fibrotic markers Ac-SDKP, MMP-1, and MMP-1/ TIMP-1 ratio were higher in patients with detectable ACEi (all p < .05). In a model adjusted for systolic blood pressure, MMP-1/TIMP-1 (p = .02) and Ac-SDKP (p < .001) levels were associated with lisinopril. We conclude that ACEi increase anti-fibrotic biomarkers in hypertensive African Americans with LVH, suggesting that they may offer added benefit over other agents in such patients.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Angiotensin‐converting enzyme inhibitors increase anti‐fibrotic biomarkers in African Americans with left ventricular hypertrophy

Romero

Mathew

Wasinski

et al. 2021

J of Clinical Hypertension

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“…A study by Xu et al showed an association between low temperature and increased arterial blood pressure, which may indirectly alter the incidence of cardiovascular diseases and explain the mechanism responsible for the effect of low temperature on stroke incidence [26]. Su et al [27] demonstrated increased activity of the renin-angiotensin system under the influence of low temperature and imbalances between Matrix Metalloproteinase-9 and its inhibitor, TIMP-1. MMP-9 is present in blood vessel walls and is responsible for the degradation of the extracellular matrix.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Selected Meteorological Factors on the Prevalence and Course of Stroke

2021

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Background: The objective of this study was to evaluate the impact of weather factors on stroke parameters. Methods: This retrospective study analyzed the records of stroke patients concerning the influence of meteorological conditions and moon phases on stroke parameters. Results: The study group consisted of 402 patients aged between 20 and 102; women constituted 49.8% of the subjects. Ischaemic stroke was diagnosed in 90.5% of patients and hemorrhagic stroke was diagnosed in 9.5% of patients. The highest number of hospitalizations due to stroke was observed in January (48 events); the lowest number was observed in July (23 events). There was no statistically significant correlation between the meteorological parameters on the day of onset and the preceding day of stroke and the neurological status (NIHSS) of patients. Mean air temperature on the day of stroke and the day preceding stroke was significantly lower in the group of patients discharged with a very good functional status (≤2 points in modified Rankin scale (mRS)) compared to the patients with a bad functional status (>2 points in mRS); respectively: 7.98 ± 8.01 vs. 9.63 ± 7.78; p = 0.041 and 8.13 ± 7.72 vs. 9.70 ± 7.50; p = 0.048). Humidity above 75% on the day of stroke was found to be a factor for excellent functional state (RR 1.61; p = 0.016). The total anterior circulation infarcts (in comparison with stroke in the other localization) were more frequent (70%) during a third quarter moon (p = 0.011). The following parameters had a significant influence on the number of stroke cases in relation to autumn having the lowest number of onsets: mean temperature (OR 1.019 95% CI 1.014–1.024, p < 0.000), humidity (OR 1.028, CI 1.023–1.034, p < 0.0001), wind speed (OR 0.923, 95% CI 0.909–0.937, p < 0.0001), insolation (OR 0.885, 95% CI 0.869–0.902, p < 0.0001), precipitation (OR 0.914, 95% CI 0.884–0.946, p < 0.0001). Conclusion: Air humidity and air temperature on the day of stroke onset as well as air temperature on the day preceding stroke are important for the functional status of patients in the acute disease period. A combination of the following meteorological parameters: lowered mean temperature and low sunshine, high humidity and high wind speed all increase the risk of stroke during the winter period. High humidity combined with high precipitation, low wind speed and low sunshine in the autumn period are associated with the lowest stroke incidence risk. A possible relationship between phases of the moon and the incidence requires further investigation.

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“…Adverse ECM remodeling is one of the key pathological processes in myocardial I/R injury (11). MMP activities are inhibited by tissue inhibitors of matrix metalloproteinases (TIMPs), of which there are four subtypes, TIMP1-4 (12). TIMP1 may serve as a plasma biomarker for predicting prognosis following MI (13).…”

Section: Co-expression Of Tissue Kallikrein 1 and Tissue Inhibitor Ofmentioning

confidence: 99%

Co‑expression of tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 improves myocardial ischemia‑reperfusion injury by promoting angiogenesis and inhibiting oxidative stress

Huang

Chen²,

et al. 2020

Mol Med Rep

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Renin-angiotensin system activation and imbalance of matrix metalloproteinase-9/tissue inhibitor of matrix metalloproteinase-1 in cold-induced stroke

Cited by 16 publications

References 54 publications

Angiotensin‐converting enzyme inhibitors increase anti‐fibrotic biomarkers in African Americans with left ventricular hypertrophy

Angiotensin‐converting enzyme inhibitors increase anti‐fibrotic biomarkers in African Americans with left ventricular hypertrophy

The Influence of Selected Meteorological Factors on the Prevalence and Course of Stroke

Co‑expression of tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 improves myocardial ischemia‑reperfusion injury by promoting angiogenesis and inhibiting oxidative stress

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