Renin inhibition and microalbuminuria development: meaningful predictor of kidney disease progression

Silva, Lalitha De; Weir, Matthew R.

doi:10.1097/mnh.0b013e32833d14c3

“…Finally, about 90% of the study population used an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker at inclusion, which are known to be effective in attenuating albuminuria. 35 This may have masked a possible effect of BAT on the progression of proteinuria.…”

Section: Discussionmentioning

confidence: 99%

Renal Responses to Long-Term Carotid Baroreflex Activation Therapy in Patients With Drug-Resistant Hypertension

Alnima¹,

Leeuw

²

,

Tan³

et al. 2013

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“…Microalbuminuria (MAU) was identified as an early indicator of kidney disease using the 24 h microalbuminuria method 22 , 23 . Urine samples were collected within 24 h and submitted for analysis 22 , 23 .…”

Section: Methodsmentioning

confidence: 99%

“…Microalbuminuria (MAU) was identified as an early indicator of kidney disease using the 24 h microalbuminuria method 22 , 23 . Urine samples were collected within 24 h and submitted for analysis 22 , 23 . Microalbuminuria was determined by pyrogallol red molybdate complex method, with the normal reference value of 24 h microalbuminuria being 0–150 mg 22 , 23 .…”

Section: Methodsmentioning

confidence: 99%

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Sympathetic skin response for early detection of type 2 diabetic peripheral neuropathy and nephropathy

Liu,

Tan,

Ma

et al. 2023

J of Diabetes Invest

2

0

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BackgroundDiabetic peripheral neuropathy (DPN) and diabetic nephropathy (DN) are common complications of type 2 diabetes mellitus (T2DM). Although nerve conduction studies (NCS) and sympathetic skin response (SSR) can detect DPN, the more sensitive method for early diagnosis remains unclear. Furthermore, whether DPN can be used as a predictor for diabetic nephropathy needs clarification.MethodsWe evaluated nerve conduction studies, sympathetic skin response, and the diabetic nephropathy indicator microalbuminuria (MAU) in 192 patients with type 2 diabetes mellitus and 50 healthy controls.ResultsPatients with type 2 diabetes mellitus showed a lower sensory nerve conduction velocity (SCV), sensory active nerve potential (SNAP), motor nerve conduction velocity (MCV), and compound motor action potential (CMAP) than the controls on NCS. Abnormal rates for nerve conduction studies and sympathetic skin response were 75.0% and 83.3%, respectively, in patients with type 2 diabetes mellitus. Interestingly, 54.2% of patients with normal nerve conduction studies had an abnormal sympathetic skin response. Moreover, we found a positive correlation between sympathetic skin response and microalbuminuria for the first time. The abnormal rate of microalbuminuria was 53.8%, lower than that of abnormal nerve conduction studies or sympathetic skin response patients.ConclusionSympathetic skin response is a more sensitive method than nerve conduction studies for the early diagnosis of diabetic peripheral neuropathy. Abnormal sympathetic skin response might serve as an indicator for early diabetic nephropathy. Additionally, diabetic peripheral neuropathy may occur earlier than diabetic nephropathy in the development of type 2 diabetes mellitus.

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