Reno-protective effect of protocatechuic acid is independent of sex-related differences in murine model of UUO-induced kidney injury

Saad, Karim M.; Salles, Évila Lopes; Naeini, Sahar Emami; Baban, Babak; Abdelmageed, Marwa E.; Abdelaziz, Rania R.; Suddek, Ghada M.; Elmarakby, Ahmed A.

doi:10.1007/s43440-023-00565-2

Pharmacol. Rep

2024

DOI: 10.1007/s43440-023-00565-2

|View full text |Cite

Reno-protective effect of protocatechuic acid is independent of sex-related differences in murine model of UUO-induced kidney injury

Karim M. Saad,

Évila Lopes Salles,

Sahar Emami Naeini

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Sex dimorphism in kidney health and disease: mechanistic insights and clinical implication

Steiger,

Li,

Bruchfeld

et al. 2025

Kidney International

View full text Add to dashboard Cite

Sex dimorphism in kidney health and disease: mechanistic insights and clinical implication

Steiger,

Li,

Bruchfeld

et al. 2025

Kidney International

View full text Add to dashboard Cite

Protective Effects of Tormentic Acid on Unilateral Ureteral Obstruction-Induced Renal Injury, Inflammation, and Fibrosis: A Comprehensive Approach to Reducing Oxidative Stress, Apoptosis, and Ferroptosis

Yang,

Kim,

Gwon

et al. 2024

Antioxidants

View full text Add to dashboard Cite

Chronic kidney disease (CKD) progresses through mechanisms involving inflammation, fibrosis, and oxidative stress, leading to the gradual structural and functional deterioration of the kidneys. Tormentic acid (TA), a triterpenoid compound with known anti-inflammatory and antioxidant properties, shows significant potential in counteracting these pathological processes. This study explored the protective role of TA in a unilateral ureteral obstruction (UUO)-induced CKD model. Mice received TA through intraperitoneal injections at a dosage of 5 mg/kg per day for 8 consecutive days, commencing a day before the UUO procedure. The TA treatment significantly improved both structural and functional kidney injury. It suppressed cytokine expression and reduced immune cell infiltration, inhibited the activation of the mitogen-activated protein kinase cascade, and alleviated endoplasmic reticulum stress. Moreover, TA displayed potent anti-fibrotic effects by reversing epithelial-to-mesenchymal transition and inhibiting Smad2/3 activation, reducing extracellular matrix deposition. TA also mitigated oxidative stress by attenuating lipid peroxidation and boosting antioxidant defenses. Additionally, it inhibited apoptosis and ferroptosis by reducing oxidative stress and modulating key cell death markers. Collectively, these findings indicate that TA provides comprehensive renoprotection in the UUO model by effectively targeting inflammation, fibrosis, oxidative stress, and tubular cell death in CKD progression.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Reno-protective effect of protocatechuic acid is independent of sex-related differences in murine model of UUO-induced kidney injury

Cited by 2 publications

References 89 publications

Sex dimorphism in kidney health and disease: mechanistic insights and clinical implication

Sex dimorphism in kidney health and disease: mechanistic insights and clinical implication

Protective Effects of Tormentic Acid on Unilateral Ureteral Obstruction-Induced Renal Injury, Inflammation, and Fibrosis: A Comprehensive Approach to Reducing Oxidative Stress, Apoptosis, and Ferroptosis

Contact Info

Product

Resources

About