1965
DOI: 10.1161/01.res.17.1.57
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Renomedullary Vasodepressor Substance, Medullin

Abstract: The chemical and physiological properties of renomedullary depressor substances were investigated utilizing the normotensive, vagotomized, pentolinium-treated rat for assay. By a combination of solvent extraction, column chromatography, and thin-layer chromatography, three biologically active acidic lipids were isolated from rabbit renal medulla. The first compound, called medullin, is an acidic lipid with potent vasodepressor and relatively weak nonvascular smooth muscle-stimulating properties. Ultraviolet an… Show more

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Cited by 163 publications
(16 citation statements)
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“…The renal medullas were separated from cortex by scissor dissection [7]. The tissue was minced and homogenized in 4 volumes of 0.1 M potassium phosphate buffer pH 7.4 containing 20 mM EDTA, 1 mM reducedglutathione and 5,6,8,9,11,12,14,15-octatritioarachidonic acid.…”
mentioning
confidence: 99%
“…The renal medullas were separated from cortex by scissor dissection [7]. The tissue was minced and homogenized in 4 volumes of 0.1 M potassium phosphate buffer pH 7.4 containing 20 mM EDTA, 1 mM reducedglutathione and 5,6,8,9,11,12,14,15-octatritioarachidonic acid.…”
mentioning
confidence: 99%
“…The mechanism of hypotensive action of prostaglandins is by direct peripheral arter iolar vasodilation [25], When PGA2 was in jected intravenously into the normotensive dog, the fall in blood pressure was associated with a rise in cardiac output and a significant decrease in total peripheral resistance. The increase in cardiac output was due to a baroreceptor-mediated rise in HR.…”
Section: Discussionmentioning
confidence: 99%
“…Studies in laboratory animals (9,13,14,(27)(28)(29) and in man (17,(30)(31)(32)(33) have demonstrated potent effects of prostaglandins on central and peripheral hemodynamics through what is believed to be an action on adenyl cyclase, which is not yet fully characterized. The prostaglandin A and E compounds have been shown in experimental animals to cause a lowering of arterial pressure and an associated tachycardia, whereas the prostaglandin F compounds elevate arterial pressure and have a negligible effect on heart rate.…”
Section: Discussionmentioning
confidence: 99%