Renoprotective Effect of Angiotensin-Converting Enzyme Inhibitor Combined with α1-Adrenergic Antagonist in Spontaneously Hypertensive Rats with Renal Ablation

Abstract

To assess the renal benefits of combined angiotensin-converting enzyme inhibition and 1-adrenergic antagonism, we studied the antihypertensive and renoprotective effects of temocapril (TMP) alone and in combination with doxazosin (DOX) in spontaneously hypertensive rats (SHR)/Izumo rats with renal ablation.Five-Sixths-nephrectomized rats were assigned to receive TMP (10 mg/kg/day) (TMP group), TMP plus DOX

Impact of Hypertension and Hypertension-Related Vascular Lesions in IgA Nephropathy

“…Benign nephrosclerosis may be superimposed with IgAN. Hypertension is a well known risk factor for renal prognosis (4,5,(22)(23)(24). In our study, we histopathologically showed that vascular lesions, rather than mesangial cell proliferation, play an important role in glomerular sclerosis.…”

The L/N-Type Calcium Channel Blocker, Cilnidipine, Reduces Heart Rate and Albuminuria in Patients with Type 2 Diabetes

“…This indicates that inhibition of sympathetic nervous activity might be directly involved in the reduction in albuminuria. α 1 -Adrenergic blockers have been reported to reduce glomerular arteriolar resistance 22 and urinary excretion of albumin 23 in spontaneously hypertensive rats. Moreover, the centrally acting sympatholytic agent, moxonidine, has been reported to reduce glomerulosclerosis and microalbuminuria in vitro 24 and microalbuminuria in patients with essential hypertension.…”

Upregulation of the brain renin–angiotensin system in rats with chronic renal failure

“…However, subtotal nephrectomy in SHR results in reduction of afferent arteriolar resistance in the remnant kidney, which allows transmission of systemic hypertension and elevation of the glomerular capillary pressure. This haemodynamic change is demonstrated to be associated with a sharp increase in protenuria and acceleration of focal and segmental glomerular sclerosis (Anderson & Brenner 1995, Kanazawa et al 2004).…”