Renoprotective effect of red grape (Vitis vinifera L.) juice and dark raisins against hypercholesterolemia-induced tubular renal affection in albino rats

Ali, Soad Shaker; Alahmadi, Ahlam A.; Hamdy, Raid M.; Huwait, Etimad; Alansari, A; Ayuob, Nasra Naeim

doi:10.5603/fm.a2018.0069

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…In addition, hypercholesterolemia provoked alterations in glomerular size and structure. Similar results were reported in other studies, where experimentally induced hypercholesterolemia by HCD impaired renal functions and structure [38,39]. Likewise, in cardiac and hepatic tissues, hypercholesterolemic rats showed elevated oxidative stress and lipid peroxidation, which is evidenced by diminished GSH and antioxidant enzyme activities as well as elevated TBARS levels.…”

Section: Discussionsupporting

confidence: 90%

Renin angiotensin system blockage by losartan neutralize hypercholesterolemia-induced inflammatory and oxidative injuries

et al. 2020

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Objectives: This study explores the protective role of losartan (LT) against oxidative and inflammatory damages in different physiological systems including heart, liver, and kidney tissue in hypercholesterolemic rats. Methods: After induction of hypercholesterolemia by high cholesterol diet for 6 weeks, LT was administered for 4 weeks. In serum, the levels of lipoproteins, aminotransferases, creatine kinases, urea, apoptosis, and inflammatory markers were measured. In cardiac, hepatic, and renal tissues, lipid peroxidation product and GSH as well as antioxidant enzymatic activities were assayed. Finally, histopathological assessment evaluated the structural damage in cardiac, hepatic, and renal tissues. Results: Serum markers of cardiac, hepatic, and renal toxicities including creatine kinases, aminotransferases, and urea were attenuated by LT in hypercholesterolemic animals. Moreover, LT markedly corrected the elevated levels of lipoproteins, apoptosis, and inflammatory biomarkers. Hypercholesterolemia-induced lipid peroxidation, low GSH levels, and diminished activities of antioxidant enzymes were prominently improved in LT treated animals. Histopathological alterations by hypercholesterolemia in heart, liver, and kidney tissues were ameliorated by LT. Conclusion: This study confirmed the pathological enrollment of renin-angiotensin system in hypercholesterolemia-associated metabolic alterations. LT had a significant cardiac, hepatic, and renal protective role against these impairments through down-regulation of oxidative damage, inflammation and necrosis.

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Section: Discussionsupporting

confidence: 90%

Renin angiotensin system blockage by losartan neutralize hypercholesterolemia-induced inflammatory and oxidative injuries

et al. 2020

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“…Feeding rats with HCD altered the structure of renal tubules. However, the administration of both RGJ and DR significantly improved the lipid profile, the HDL-c, reduced the blood glucose, increased the insulin level and ameliorated the histopathological alteration in the renal tubules [39]. Again, the renoprotective effect of raisins was demonstrated.…”

Section: Animal Modelsmentioning

confidence: 91%

“…Hypercholesterolemia, a risk factor for CVDs, has become the most frequently encountered medical problem worldwide, bad dietary habits being among its principal causes [39].…”

Section: Hypercholesterolemiamentioning

confidence: 99%

Is Eating Raisins Healthy?

et al. 2019

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Raisins are dried grapes consumed worldwide that contain beneficial components for human health. They are rich in fiber and phytochemicals such as phenolic compounds. Despite a 60% sugar content, several studies have reported health-promoting properties for raisins and this review compiles the intervention studies, as well as the cell line and animal model studies carried out to date. It has been demonstrated that raisins possess a low-to-moderate glycemic index, which makes them a healthy snack. They seem to contribute to a better diet quality and may reduce appetite. Their antioxidant capacity has been correlated to the phenolic content and this may be involved in the improvement of cardiovascular health. In addition, raisins maintain a good oral health due to their antibacterial activity, low adherence to teeth and an optimum oral pH. Raisin consumption also seems to be favorable for colon function, although more studies should be done to conclude this benefit. Moreover, gut microbiota could be affected by the prebiotic content of raisins. Cell line and animal model studies show other potential benefits in specific diseases, such as cancer and Alzheimer’s disease. However, deeper research is required and future intervention studies with humans are needed. Overall, incorporating an 80–90 g portion of raisins (half a cup) into the daily diet may be favorable for human health.

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COVID-19-Induced Kidney Disease: Ethnopharmacological Intervention to Ameliorate Kidney Damage and Improve Kidney Function

Peter,

Kalpana,

Velaga

et al. 2023

Ethnopharmacology and Drug Discovery for COVID-19: Anti-Sars-CoV-2 Agents From Herbal Medicines and Natural Products

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Renoprotective effect of red grape (Vitis vinifera L.) juice and dark raisins against hypercholesterolemia-induced tubular renal affection in albino rats

Abstract: This study highlighted the importance of supplementation of red grape and raisins in protection against the harmful effects induced by deposition of fat on the renal tubules structure and function.

Cited by 4 publications

References 37 publications

Renin angiotensin system blockage by losartan neutralize hypercholesterolemia-induced inflammatory and oxidative injuries

Renin angiotensin system blockage by losartan neutralize hypercholesterolemia-induced inflammatory and oxidative injuries

Is Eating Raisins Healthy?

COVID-19-Induced Kidney Disease: Ethnopharmacological Intervention to Ameliorate Kidney Damage and Improve Kidney Function

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