Renoprotective Effect of Taxifolin and/or Vitamin C on Diazinon-Induced Renal Injury in Rats

Abstract

Insecticides have come to be used in a wrong way and uncontrollably, leading to an increase in the incidence of chronic diseases such as chronic nephropathies, diabetes, and other metabolic disorders. Objective: To evaluate the protective effect of Taxifolin and/or vitamin C against Diazinon-induced renal dysfunction. Methods: Thirty-six female rats were divided into six groups gavaged orally for 30 days. Group 1 received 20 mg/kg DZN. Group 2 received 25 mg/kg Taxifolin, 100 mg/kg vitamin C, and then 20 mg/kg DZN. Group 3 received 25 mg/kg Taxifolin and then 20 mg/kg DZN. Group 4 received 100 mg/kg vitamin C and then 20 mg/kg DZN. Group 5 received 25 mg/kg Taxifolin and then 100 mg/kg vitamin C. Finally, group 6 received distilled water. In the end, the rats were sacrificed and their blood and kidneys were collected for biochemical analysis and histopathology. Conclusion: Sub-acute administration of Taxifolin and vitamin C provides a renoprotective effect against oxidative stress induced by DZN.

Effects of taxifolin from enzymatic hydrolysis of Rhododendron mucrotulatum on hair growth promotion

“…In addition, it has been proven to be effective in diabetic cardiomyopathy by inhibiting oxidative stress to regulate mitochondrial function and inhibit cell apoptosis (Sun et al, 2014;Zheng et al, 2021). Moreover, taxifolin exerts cardioprotective effects against diazinon-induced myocardial injury in rats (Najeb et al, 2022). However, it has been reported that taxifolin aglycone is found in complex preparations such as silymarin (LegalonTM), is presented in very small amounts, and is rarely used alone (Kroll et al, 2007;Weidmann, 2012).…”

Enhancing the Bioavailability of Quercetin by Concomitant Administration with Enzyme Inhibitor

“…(11) Que and its derivatives are of the most powerful antioxidants found in plants and contains several OH groups in its structure, which may further contribute to photodegradation. (8,12) It is one of more than 4000 plant phenolics that are naturally available, (13) in many vegetables, fruits and drinks ingested from the daily diet, (14) including onions, broccoli, apples, berries, (15) and citrus fruits, (9) it is ubiquitously present in wine and tea. (16,17) Que is well known for its vasodilator, antihypertensive effects, antiatherosclerotic, antiobesity, antihypercholesterolemic, and antidiabetic activities.…”