Renoprotective Effects of Cotransplanted Allogeneic Testicular Sertoli Cells in a Renal Acute Rejection Model in Rats

Abstract

Objectives: We sought to study the renoprotective effect of cotransplanted allogeneic testicular Sertoli cells on renal acute rejection in rats. Materials and Methods: A renal acute rejection model using kidneys from Sprague-Dawley (n=30) transplanted into Wistar rats (n=30) was constructed. The rats were randomly divided into 3 groups: (1) the cyclosporine group, which was treated with daily hypodermic injections of cyclosporine (15 mg/kg) after transplant, (2)

Production of Macrophage Inhibitory Factor (MIF) by Primary Sertoli Cells; Its Possible Involvement in Migration of Spermatogonial Cells

“…It was demonstrated that Sertoli cells are involved in the protection of rejection various grafts (Yin et al, ; Zheng et al, ; Ramji et al, ; Bistoni et al, ; Mai et al, ; Li et al, ) and MIF might be part of this protection process.…”

Xenogeneic Sertoli cells modulate immune response in an evolutionary distant mouse model through the production of interleukin‐10 and PD‐1 ligands expression

“…Co‐transplantation studies confirmed their ability to provide a tolerogenic environment at sites other than the testis. Several studies show that SCs can prolong survival of allo‐ or xenografts, including pancreatic islets, 8 skin grafts, 9 heart, 10 kidney, 11 hepatocytes, 12 and neurons 13 …”

“…Generation of regulatory T-cells (Tregs), 5 expressions of FasL and indoleamine 2, 3-dioxygenase (IDO) are other relevant mechanisms of SC immunosuppressive activity were reviewed by Kaur et al 6 and Luca et al 7 Co-transplantation studies confirmed their ability to provide a tolerogenic environment at sites other than the testis. Several studies show that SCs can prolong survival of allo-or xenografts, including pancreatic islets, 8 skin grafts, 9 heart, 10 kidney, 11 hepatocytes, 12 and neurons. 13 The survival of xenogeneic SCs has been confirmed in several studies.…”