Renoprotective Effects of Pituitary Adenylate Cyclase-Activating Polypeptide 38 (PACAP38)

Khan, M-Altaf; Batuman, Vecihi

doi:10.1007/978-3-319-35135-3_18

Cited by 3 publications

(2 citation statements)

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“…Such efficacy of PACAP counteracting ischemic lesions has been subsequently proven in peripheral organs, including intestinal and renal ischemia/reperfusion injuries [32,79,80]. These findings have been summarized in review papers [3,38,80], so here we briefly address the protective effects of PACAP in ischemia/reperfusion kidney injuries, highlighting the effects on inflammatory and oxidative stress mediators, and describe more recent data.…”

Section: In Vivo Protective Effects Of Pacapmentioning

confidence: 98%

“…Among others, PACAP has protective effects in liver [31] and intestinal ischemia [32], inflammatory lung and skin conditions [33,34], has cardioprotective effects in various models of cardiomyocyte damage [35,36] and protects pancreatic beta cells [37]. Of the peripheral organs, most data have been accumulated on the protective effects of PACAP in the kidney against various lesions, both in vitro and in vivo [3,38]. The aim of the present study is to provide an updated review on the nephroprotective effects of PACAP.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Neuropeptide Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Is Protective in Inflammation and Oxidative Stress-Induced Damage in the Kidney

Horváth

Opper

Reglődi

2019

IJMS

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Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic neuropeptide with a widespread distribution throughout the entire body including the urinary system. PACAP exerts protective actions in different injury models related to several organ systems. Its protective effect is mainly based on its antiapoptotic, anti-inflammatory and antioxidant effects. The present review aims to summarize the effects of PACAP in pathologies associated with inflammation and oxidative stress-induced damage in the kidney. Both in vitro and in vivo data are available proving its protective actions against oxidative stress, hypoxia, renal ischemia/reperfusion, diabetic nephropathy, myeloma kidney injury, amyloidosis and different types of drug-induced nephropathies. Data showing the nephroprotection by PACAP emphasize the potential of PACAP’s therapeutic use in various renal pathologies.

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